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17 janvier 2019: 1 événement

  • Département Biologie des Génomes

    Jeudi 17 janvier 11:00-12:00 - Javier Lopez-Garrido - University of California, San Diego

    On how the genome shapes the spore

    Résumé : Bacillus subtilis is a bacterium with a simple developmental pathway leading to spore formation under conditions of nutrient limitation. Sporulation starts with an asymmetric cell division event, called polar septation, giving rise to two cells with different sizes and developmental fates : the smaller forespore, which becomes the metabolically dormant spore, and the larger mother cell, which dies after sporulation. Polar septation generates asymmetry that is harnessed by the activation of cell specific transcription factors that define the developmental fates of each cell. It also has a dramatic topological consequence, namely, the forespore chromosome is trapped at the middle of the sporulation septum. Spore formers have evolved a system to deal with this topological problem : a membrane protein, called SpoIIIE, is recruited to the point where the chromosome is trapped, and catalyzes the transport the chromosome from the mother cell to the forespore to guarantee that a complete genome is packed in the spore. In this talk, I will present genetic, fluorescence microscopy and cryo-electron microscopy experiments to dissect organization of the SpoIIIE DNA translocation complex. I will also show how chromosome translocation impacts forespore shape. Our results illustrate how simple biophysical interactions between core cellular components contribute to the shape of the spore.
    Contact : Yoshiharu YAMAICHI <yoshiharu.yamaichi>

    Lieu : Bibliothèque- bâtiment 34 - Campus CNRS de Gif-sur-Yvette

    En savoir plus : Département Biologie des Génomes