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12 février 2019: 1 événement

  • Cytoskeleton club

    Mardi 12 février 2019 11:30-13:00 - Carsten Janke - Institut Curie, UMR CNRS 3348, Orsay

    Cytoskeleton club - Controlling microtubule functions with the tubulin code

    Résumé : The tubulin code is a signalling mechanism that, by modulating the properties of single tubulin units of microtubules, controls and fine-tunes microtubule functions in cells. The code is generated by the expression of alternative tubulin genes, called ‘isotypes’, and by the generation of a range of complex posttranslational modifications. Polyglutamylation, polyglycylation and detyrosination are modifications localized at the outer surface of microtubules, and are therefore likely to regulate the interactions with microtubule-associated proteins. Enzymes that catalyse those modifications are members of an evolutionary conserved family of tubulin tyrosine ligase like proteins (TTLL), whereas reverse enzymes (until present only deglutamylases have been identified) are members of the cytosolic carboxy peptidase family (CCP). Our current work on mouse models for glutamylation and glycylation has revealed an important role of polyglutamylation in neurodegeneration, which is most likely mediated by alterations of neuronal transport. Glycylation plays a key role in stabilizing cilia and flagella, and is also important for primary cilia. Moreover, both polyglutamylation and polyglycylation play a key role in male fertility. Strikingly, the often subtle cellular phenotypes generated by altered tubulin modifications translate into serious defects on the organism level, such as neurodegeneration or male infertility, which underpins the emerging importance of the tubulin code in human pathologies.
    Contact : Julie Ménétrey

    Lieu : Bibliothèque - bât. 34

    En savoir plus : Cytoskeleton club