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19 février 2019: 1 événement

  • Département Biochimie, Biophysique et Biologie Structurale

    Mardi 19 février 2019 11:00-12:30 - Ricardo Cesar Guerrero Ferreira - ETH Zürich, Dept. Biosysteme Basel, Mattenstrasse 26, 4058 Basel (Switzerland)

    The structure of alpha-synuclein fibrils by cryo-electron microscopy

    Résumé : Synucleinopathies are progressive disorders characterized by the presence of intracellular inclusions such as Lewy bodies and Lewy neurites which contain alpha-synuclein fibrils. Using cryo-electron microscopy techniques we determined the structure of these fibrils at high resolution. The fibril core, the non-amyloid component region, and the residues responsible for the interaction of the two component protofilaments are well resolved in the EM maps and the corresponding atomic models. We propose a mechanism of fibril elongation, growth and stability. Our results also provide valuable insights to support the rational design of molecules for diagnosis and treatment of synucleinopathies.

    Lieu : Auditorium I2BC - Bât. 21, Campus de Gif-sur-Yvette

    En savoir plus : Département Biochimie, Biophysique et Biologie Structurale