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21 mars 2019: 1 événement

  • Evènements I2BC

    Jeudi 21 mars 2019 14:00-15:00 - Tom Owen-Hughes - School of Life Sciences, University of Dundee

    Structure and function of chromatin remodelling ATPase’s and their dysfunction in human disease

    Résumé : The genomes of eukaryotes are associated with histone proteins to form a DNA protein complex called chromatin. The regulation of chromatin structure provides one means by which eukaryotic organisms regulated access to DNA. One means by which this is achieved involves the action of an extended family molecular motor proteins, known as chromatin remodelling ATPases. Advances to electron microscopy provide an opportunity to gain major new insights into how these motor proteins interact with chromatin. Our ongoing work providing insight into how these molecular machines reconfigure nucleosomes will be presented. It has become apparent that the genes that encode these motor proteins, and additional subunits of the multi-subunit complexes they are found in, are often genetically altered in cancers of different tissues and a number of neurological disorders. This means it is important to determine how loss of these enzymes affects chromatin structure and gene regulation. With this aim we have established targeted degrons characterise the consequences of removing different enzyme subunits over time. The ongoing characterisation of these changes will be presented.

    Lieu : Auditorium I2BC - Bât. 21, Campus de Gif-sur-Yvette

    Notes de dernières minutes : ATTENTION DATE ET HEURE MODIFIEES

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