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29 mars 2019: 1 événement

  • Département Biologie des Génomes

    Vendredi 29 mars 2019 11:00-12:00 - Claude Bruand - Laboratoire des Interactions Plantes-Microorganismes (LIPM), Université de Toulouse, INRA, CNRS, Castanet-Tolosan, France

    Non-homologous end-joining in bacteria : from DNA double-strand break repair to acquisition of heterologous DNA

    Résumé : DNA double-strand breaks (DSB) in bacteria can be repaired either by homologous recombination dependent on the universal RecA protein, or by non-homologous end-joining (NHEJ), a two-component system relying on the Ku and LigD proteins, present in 20 % of bacterial species. Strikingly, Sinorhizobium meliloti encodes several potential Ku and LigD proteins, which prompted us to perform a comprehensive genetic analysis of NHEJ in this bacterial species. We report here the results of this study, which brings new insights into the mechanism, regulation and putative function of NHEJ in bacteria.
    Dupuy P., Sauviac L. and Bruand C. (2018) Stress-inducible NHEJ in bacteria : function in DNA repair and acquisition of heterologous DNA. Nucleic Acids Res. doi : 10.1093/nar/gky1212.
    Bertrand C., Thibessard A., Bruand C., Lecointe F., Leblond P. (2019) NHEJ in bacteria : a never ending story. Mol Microbiol. doi : 10.1111/mmi.14218
    Contact : Julien Bischerour and Mireille Bétermier

    Lieu : Salle des séminaires- bâtiment 26 - Campus CNRS de Gif-sur-Yvette

    En savoir plus : Département Biologie des Génomes