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14 mai 2019: 2 événements

  • Département Microbiologie

    Mardi 14 mai 11:30-12:30 - Victor Kreis - ARNCLO team, Microbiology department, I2BC

    Role of noncoding RNAs in the pathogenesis of infections related to an emerging human enteropathogen, Clostridium difficile

    Résumé : Clostridium difficile is the leading cause of diarrhea associated with adult care in industrialized countries. The incidence of these infections continues to increase and this trend is accentuated by the general aging of the population. C. difficile represents today a real danger for human and animal health. Better understanding the regulation of colonization process of the digestive tract seems essential for the study of this emerging pathogen. We have recently discovered the existence of a large number of regulatory RNAs in C. difficile. We will use high throughput approaches to identify RNAs induced during infection as important virulence factors. We have already identified several regulatory RNAs specific to a particularly virulent strain that can contribute to this phenotype. Their detailed study will make possible to anticipate the emergence of new hypervirulent strains and better understand the adaptation mechanisms developed by this pathogen. This project will also allow uncovering the role of RNAs in the regulatory network controlling critical processes for the development of C. difficile in the host. These data will be used to develop new diagnostic and therapeutic approaches.

    Lieu : Salle Kalogeropoulos - Bât. 400, Campus d’Orsay

    En savoir plus : Département Microbiologie
  • Cytoskeleton club

    Mardi 14 mai 11:30-12:30 - Martin Lenz - Laboratoire de Physique Théorique et Modèles Statistiques (LPTMS), UMR CNRS 8626, Orsay

    Cytoskeleton club - Why does actomyosin contract ?

    Résumé : The motion of living cells is largely due to the interaction of semi-flexible actin filaments (F-actin) and myosin molecular motors. It is often assumed that the relative sliding of these two components is sufficient to account for all actomyosin-based motion. While this is correct in our highly organized striated muscle, we question the application of this dogma to less ordered actomyosin systems, thus reexamining a cornerstone of our understanding of cellular motion.
    Contact : Christophe Le Clainche

    Lieu : Bibliothèque - bât. 34

    En savoir plus : Cytoskeleton club