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27 mai 2019: 1 événement

  • Département Biochimie, Biophysique et Biologie Structurale

    Lundi 27 mai 11:00-12:00 - Jérôme Gouge - Structural Biology Department, Institute of Cancer Research, London, UK.

    Human RNA polymerase III recruitment at the type 3 promoters

    Résumé : The RNA Polymerase III controls transcription of the short and untranslated RNA, such as the entire pool of tRNA. Its recruitment relies on 3 subunits : i) TBP, ii) Bdp1 that opens the DNA bubble and iii) either Brf1 or Brf2. While Brf1 is found across all eukaryotes at type 1 and 2 promoters, Brf2 is present only in higher metazoans at the type 3 promoters. Brf2 has been linked to tumorigenesis but the underlying mechanisms remain elusive. Integration of structural, biochemical and in vitro data provided a model explaining Brf2 activation in cancer and how the promoter can be opened in the Pol III system in absence of ATP hydrolysis.

    Lieu : Auditorium I2BC - Bât. 21, Campus de Gif-sur-Yvette

    Notes de dernières minutes : Candidature à une création d’équipe ATIP

    En savoir plus : Département Biochimie, Biophysique et Biologie Structurale