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14 juin 2019: 1 événement

  • Département Biologie des Génomes

    Vendredi 14 juin 11:00-12:00 - Romain MERCIER - Institute of Microbiology of the Mediterranean, Marseille, France

    Molecular basis of Twitching motility regulation in Myxococcus xanthus

    Résumé : In living organisms, surface cell movements are essential for environmental exploration and multicellular development, and are also at the basis of cancer cell dissemination. In Bacteria, surface cell movements are mediated by a class of widespread nanomachines called Type-IV Pili (TFP). TFP-based motility (or twitching), is at the root of highly cooperative cell movements, which on pathogens allow host colonization and biofilm formation. Despite an extensive knowledge on TFPs molecular structure, the determinants and regulations that convert TFPs into highly efficient motility machines remain largely unknown. In the model organism Myxococcus xanthus, TFP-driven group movements promote predation on prey bacteria and the formation of multicellular fruiting bodies (biofilm). Here, we will present the discovery of a new cytoplasmic platform that regulates TFP activity. We will also discuss how this cytoplasmic platform might orchestrate Twitching motility in M. xanthus.

    Lieu : Salle des séminaires - bâtiment 26 - campus de Gif-sur-Yvette

    En savoir plus : Département Biologie des Génomes