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20 septembre 2019: 2 événements

  • Département Biologie des Génomes

    Vendredi 20 septembre 11:00-12:00 - Christian MUCHARDT - Institut Pasteur, Paris

    Regulation of transcription initiation and mRNA maturation by silencing machineries

    Résumé : Machineries imposing long-term transcriptional repression – or transcriptional gene silencing – are essential to prevent expression of repeated and potentially mobile DNA elements, and to ensure the timely and robust transcriptional repression of genes involved in cell differentiation and development. Yet, silencing machineries also participate in transcriptional regulation of inducible genes. In particular, many genes involved in innate immune defense are regulated by members of the HP1 family, keeping them in check in the absence of stimulation, but also regulating their alternative splicing while they are expressed. These mechanisms will be discussed in the context of autoimmune diseases and ageing.

    Contact : BETERMIER Mireille (Mireille.BETERMIER

    Lieu : Salle des séminaires - bâtiment 26 - campus de Gif-sur-Yvette

    En savoir plus : Département Biologie des Génomes
  • Département Virologie

    Vendredi 20 septembre 11:00-12:00 - Quentin NEVERS - Institut Pasteur, Paris

    IFITM proteins inhibit cell-cell fusion mediated by endogenous retroviral envelopes

    Lieu : Salle des séminaires - Bâtiment 14C, Campus de Gif-sur-Yvette

    En savoir plus : Département Virologie