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24 septembre 2019: 1 événement

  • Département Biochimie, Biophysique et Biologie Structurale

    Mardi 24 septembre 11:00-12:00 - Joanna Timmins - IBS, Univ. Grenoble Alpes, CNRS, CEA

    Nucleoid organisation and dynamics in Deinococcus radiodurans

    Résumé : In all organisms, genomic DNA is compacted several orders of magnitude and yet must remain accessible for essential DNA-related processes. Using a combination of biochemical, biophysical and advanced imaging approaches, we have explored the nucleoid organization in Deinococcus radiodurans, a relatively large, spherical bacterium, well-known for its exceptional radioresistance. This work has revealed that its nucleoid is highly compact, but also surprisingly dynamic, adopting various configurations, including the previously described toroid. A major player in the organization of bacterial nucleoids is the highly abundant histone-like HU protein that largely coats the genomic DNA. We have investigated HU’s mode of DNA binding and its ability to condense the genomic DNA. Taken together, these findings demonstrate that bacterial nucleoids are tightly regulated by cell shape and cell cycle progression, and suggest that the HU protein plays a key role in this process.

    Lieu : Salle de conférence - Bat 144, Campus CEA Saclay

    En savoir plus : Département Biochimie, Biophysique et Biologie Structurale

24 septembre 2019: 1 événement

  • Département Biochimie, Biophysique et Biologie Structurale

    Mardi 24 septembre 14:00-17:00 - Jingqi DAI - Equipe Enveloppe Nucléaire, Télomères et Réparation de l'ADN, I2BC

    Mécanisme moléculaire de l’endonucléase Mlh1-Mlh3 dans la voie de réparation des mésappariements de l’ADN et dans les processus de recombinaison en méiose

    Lieu : amphithéatre Bloch - Orme des Merisiers (CEA, accès libre)

    Notes de dernières minutes : Accès amphithéatre : http://iramis.cea.fr/spec/Contact/visitAmphiBloch.php

    En savoir plus : Département Biochimie, Biophysique et Biologie Structurale