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27 septembre 2019: 1 événement

  • Département Biologie des Génomes

    Vendredi 27 septembre 11:00-12:00 - Frederic FROTTIN - Max Planck Institute of Biochemistry, D-82152 Martinsried, Germany

    Phasing-in protein quality control in the nucleus : the nucleolus is a phase-separated protein quality control compartment with novel chaperone-like properties.

    Résumé : Protein quality control in the nucleus is not well understood. The nucleus contains several non-membrane bound subcompartments forming liquid-like condensates. The largest of these is the nucleolus, the site of ribosome biogenesis. Metastable nuclear proteins that misfold upon heat stress enter the nucleolus where they avoid irreversible aggregation and remain competent for Hsp70 dependent refolding upon recovery from stress. Prolonged stress or the uptake of proteins associated with neurodegenerative diseases resulted in loss of reversibility. These findings demonstrate how the properties of a phase-separated compartment can be utilized in protein quality control, a fundamental biological function.
    Recent publications :
    The nucleolus functions as a phase-separated protein quality control compartment.
    Frottin F, Schueder F, Tiwary S, Gupta R, Körner R, Schlichthaerle T, Cox J, Jungmann R, Hartl FU, Hipp MS.
    Science. 2019 Jul 11. pii : eaaw9157. doi : 10.1126/science.aaw9157. [Epub ahead of print]
    In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
    Guo Q, Lehmer C, Martínez-Sánchez A, Rudack T, Beck F, Hartmann H, Pérez-Berlanga M, Frottin F, Hipp MS, Hartl FU, Edbauer D, Baumeister W, Fernández-Busnadiego R.
    Cell. 2018 Feb 8 ;172(4):696-705.e12. doi : 10.1016/j.cell.2017.12.030. Epub 2018 Feb 1.
    Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors.
    Kim YE, Hosp F, Frottin F, Ge H, Mann M, Hayer-Hartl M, Hartl FU.
    Mol Cell. 2016 Sep 15 ;63(6):951-64. doi : 10.1016/j.molcel.2016.07.022. Epub 2016 Aug 25.

    Lieu : Bibliothèque - bâtiment 34 - campus de Gif-sur-Yvette

    En savoir plus : Département Biologie des Génomes