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11 octobre 2019: 1 événement

  • Département Biologie Cellulaire

    Vendredi 11 octobre 11:30-12:30 - Paola DEFILIPPI - Dept. of Molecular Biotechnology and Health Sciences, MBC, University of Torino, Italie

    The scaffold protein p140Cap as a molecular hub for limiting cancer progression : a paradigm in breast cancer and neuroblastoma.

    Résumé : The p140Cap adaptor protein, encoded by the SRCIN1 gene, is a scaffold molecule physiologically expressed in few epithelial tissues, such as the mammary gland, and in neurons. However, p140Cap is also expressed in a significant subset of breast cancers and neuroblastoma tumors. In the subgroup of ERBB2-amplified breast cancers, a high p140Cap status predicts a lower probability of developing a distant event and a clear difference in survival. In the neuroblastoma tumors, SRCIN1 mRNA levels are an independent risk factor inversely correlated to disease aggressiveness. In both tumor models, p140Cap is causal in dampening tumor cell progression, impairing in vivo tumor growth, and resulting in decreased spontaneous metastasis formation. By a combination of biochemical and molecular approaches, and through the analysis of the p140Cap interactome and the related signaling pathways, we dissect how common and specific mechanisms may contribute to p140Cap ability to limit cancer progression.

    Lieu : Bibliothèque - bâtiment 34 - campus de Gif

    En savoir plus : Département Biologie Cellulaire