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15 novembre 2019: 1 événement

  • Département Biologie des Génomes

    Vendredi 15 novembre 11:00-12:00 - David LALAOUNA - Institut de Biologie Moléculaire et Cellulaire, Strasbourg

    The double life of bacterial RNA transcripts

    Résumé : Discovered in the early 80’s, small regulatory RNAs (sRNAs) are depicted as key actors in virtually all aspect of bacterial physiology (e.g. primary or secondary metabolism, cell division, virulence) [1-2]. These 50 to 500 nt-long RNA fragments are mostly involved in the post-transcriptional regulation of a subset of messenger RNAs forming their interactomes.
    Bacterial regulatory RNAs have first been characterized as exclusively originating from intergenic regions. However, recent high-throughput screenings revealed that other loci, such as untranslated regions of mRNAs [3] or transcribed spacers of tRNA transcripts [4], also serve as a source of functional regulatory RNAs.
    [1] Carrier et al., 2018. Annu Rev Microbiol. 72:141-161
    [2] Wagner and Romby, 2015. Adv Genet. 90:133-208
    [3] Lalaouna et al., 2019. NAR 47:9871-9887
    [4] Lalaouna et al., 2015. Mol Cell 58:393-405


    Contact : Philippe BOULOC (philippe.bouloc i2bc.paris-saclay.fr)

    Lieu : Salle A. Kalogeropoulos - bâtiment 400 - Campus d'Orsay

    En savoir plus : Département Biologie des Génomes