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10 décembre 2019: 1 événement

  • Cytoskeleton club

    Mardi 10 décembre 11:30-12:30 - Cécile Leduc - Institut Pasteur, Paris

    Cytoskeleton club - Molecular architecture and dynamics of intermediate filaments in glial cell migration

    Résumé : Intermediate filaments (IFs) are key players in the control of cell morphology and structure as well as in active processes such as cell polarization, migration and mechano-responses. However the regulatory mechanisms controlling IF dynamics and organization in motile cells are still poorly understood. In a first part of the talk I will show how IF network reorganizes in a polarized manner during the cell polarization and migration and provide new insights into the mechanism of coordination between the three cytoskeleton components. In a second part I will show how the molecular architecture of single intermediate filaments can be deciphered using super-resolution microscopy, and discuss how their structural organization is compatible with their cellular function as stress absorber.

    Lieu : Bibliothèque - bât. 34

    En savoir plus : Cytoskeleton club