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15 janvier 2021: 1 événement

  • Département Biologie des Génomes

    Vendredi 15 janvier 10:00-11:00 - Hidetoshi Saze - Okinawa Institute of Science and Technology, Plant Epigenetics Unit

    Epigenetic regulation of intragenic transposons and gene transcription in plant genomes

    Résumé : Genomes of higher eukaryotes contain a large number of transposable elements (TEs), that are often silenced by epigenetic mechanisms, such as histone modifications and DNA methylation. Although TE silencing adversely affects expression of nearby genes, recent studies revealed the presence of intragenic TEs marked by repressive epigenetic marks within transcriptionally permissive chromatin environments. However, molecular mechanism underlying the regulation of intragenic TEs and their potential impacts on gene expression are still poorly understood. We analyzed genome-wide distribution and epigenetic regulation of intragenic TEs in the genomes of Arabidopsis and rice, and revealed that the repressive chromatin state of intragenic TEs is critical for proper transcription and splicing of associated genes. Our study provides new insights into how intragenic TEs affect the transcriptional landscape of the plant genomes, and suggests the importance of epigenetic mechanisms for regulation of TEs within transcriptional gene units.


    Contact : Yoshiharu.YAMAICHI

    Lieu : Visio

    En savoir plus : Département Biologie des Génomes