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Accueil > Départements > Microbiologie > Dominique MENGIN LECREULX : Enveloppes Bactériennes et Antibiotiques

Dominique MENGIN LECREULX : Enveloppes Bactériennes et Antibiotiques

3. Publications


El Ghachi M., Howe N., Auger R., Lambion A., Guiseppi A., Delbrassine F., Manat G., Roure S., Peslier S., Sauvage E., Vogeley L., Rengifo-Gonzalez J.-C., Charlier P., Mengin-Lecreulx D., Foglino M., Touzé T., Caffrey M., and Kerff F. 2017. Crystal structure and biochemical characterization of the transmembrane PAP2 type phosphatidylglycerol phosphate phosphatase from Bacillus subtilis. Cellular and Molecular Life Sciences in press.

Rožman K., Lešnik S., Brus B., Hrast M., Sova M., Patin D., Barreteau H., Konc J., Janežič D., and Gobec S. 2017. Discovery of new MurA inhibitors using induced-fit simulation and docking. Bioorg. & Med. Chem. Lett. 27, 944-949.

Di Gregorio S., Fernandez S., Cuirolo A., Verlaine O., Amoroso A., Mengin-Lecreulx D., Famiglietti A., Joris B., and Mollerach M. 2017. Different VISA phenotypes selected from the same ST100-hVISA parental strain. Microb. Drug Resist. 23, 44-50.

Bosco M., Massarweh A., Iatmanen-Harbi S., Bouhss A., Chantret I., Busca P., Moore S.E., and Gravier-Pelletier C. 2017. Synthesis and biological evaluation of chemical tools for the study of Dolichol Linked Oligosaccharide Diphosphatase (DLODP). Eur. J. Med. Chem. 125, 952-964.


Iatsenko I., Kondo S., Mengin-Lecreulx D., and Lemaitre B. 2016. PGRP-SD, an extracellular pattern-recognition receptor, enhances peptidoglycan-mediated activation of the Drosophila Imd pathway. Immunity 45, 1013-1023.

Hugonnet J.E., Mengin-Lecreulx D., Monton A., den Blaauwen T., Carbonnelle E., Veckerlé C., Brun Y., van Nieuwenhze M., Bouchier C., Tu K., Rice L.B., and Arthur M. 2016. Factors essential for L,D-transpeptidase-mediated peptidoglycan cross-linking and β-lactam resistance in Escherichia coli. eLife 5, e19469.

Chérier D., Giacomucci S., Patin D., Bouhss A., Touzé T., Blanot D., Mengin-Lecreulx D., and Barreteau H. 2016. Pectocin M1 (PcaM1) inhibits Escherichia coli cell growth and peptidoglycan biosynthesis through periplasmic expression. Antibiotics 5, 36.

Fonvielle M., Sakkas N., Iannazzo L., Le Fournis C., Patin D., Mengin-Lecreulx D., El-Sagheer A., Braud E., Cardon S., Brown T., Arthur M., and Etheve-Quelquejeu M. 2016. Electrophilic RNA for peptidyl-RNA synthesis and site-specific cross-linking with tRNA-binding enzymes. Angew. Chem. Int. Ed. Engl. 55, 13553-13557.

Al-Dabbagh B., Olatunji S., Crouvoisier M., El Ghachi M., Blanot D., Mengin-Lecreulx D., and Bouhss A. 2016. Catalytic mechanism of MraY and WecA, two paralogues of the polyprenyl-phosphate N-acetylhexosamine 1-phosphate transferase superfamily. Biochimie 127, 249-257.

Šink R., Kotnik M., Zega A., Barreteau H., Gobec S., Blanot D., Dessen A., and Contreras-Martel C. 2016. Crystallographic study of peptidoglycan biosynthesis enzyme MurD : Domain movement revisited. PLoS One 11, e0152075.

Naqvi K.F., Patin D., Wheatley M., Savka M.A., Dobson R.C, Gan H.M., Barreteau H., Blanot D., Mengin-Lecreulx D., and Hudson A.O. 2016. Identification and partial characterization of a novel UDP-N-acetylenolpyruvoylglucosamine reductase/UDP-N-acetylmuramate:L-Alanine ligase fusion enzyme from Verrucomicrobium spinosum DSM 4136T. Front. Microbiol. 7, 362.

Patin D., Turk S., Barreteau H., Mainardi J.-L., Arthur M., Gobec S., Mengin-Lecreulx D., and Blanot D. 2016. Unusual substrate specificity of the peptidoglycan MurE ligase from Erysipelothrix rhusiopathiae. Biochimie 121, 209-218.


Manat G., El Ghachi M., Auger R., Baouche K., Olatunji S., Kerff F., Touzé T., Mengin-Lecreulx D., and Bouhss A. 2015. Membrane topology and biochemical characterization of the Escherichia coli BacA undecaprenyl-pyrophosphate phosphatase. PLoS One 10, e0142870.

Xu Q., Mengin-Lecreulx D., Liu X.W, Patin D., Farr C.L., Grant J.C., Chiu H.-J., Jaroszewski L., Knuth M.W., Godzik A., Lesley S.A., Elsliger M.A., Deacon A.M., and Wilson I.A. 2015. Insights into substrate specificity of NlpC/P60 cell wall hydrolases containing bacterial SH3 domains. mBio 6, e02327-14.

Perdih A., Hrast M., Pureber K., Barreteau H., Golič Grdadolnik S., Kocjan D., Gobec S., Solmajer T., and Wolber G. 2015. Furan-based benzene mono- and dicarboxylic acid derivatives as multiple inhibitors of the bacterial Mur ligases (MurC-MurF) : experimental and computational characterization. J. Comput. Aided Mol. Des. 29, 541-560.

Fer M.J., Bouhss A., Patrão M., Le Corre L., Pietrancosta N., Amoroso A., Joris B., Mengin-Lecreulx D., Calvet-Vitale S., and Gravier-Pelletier C. 2015. 5′-Methylene-triazole-substituted-aminoribosyl uridines as MraY inhibitors : Synthesis, biological evaluation and molecular modeling. Org. & Biomol. Chem. 13, 7193-7222.

Levefaudes M., Patin D., de Sousa-d’Auria C., Chami M., Blanot D., Hervé M., Arthur M., Houssin C., and Mengin-Lecreulx D. 2015. Diaminopimelic acid amidation in Corynebacteriales : new insights into the role of LtsA in peptidoglycan modification. J. Biol. Chem. 290, 13079-13094.

Soudais C., Samassa F., Sarkis M., Le Bourhis L., Bessoles S., Blanot D., Hervé M., Schmidt F., Mengin-Lecreulx D., and Lantz O. 2015. In vitro and in vivo analysis of the Gram-negative bacteria-derived riboflavin precursor derivatives activating mouse MAIT cells. J. Immunol. 194, 4641-4649.

Cumby N., Reimer K., Mengin-Lecreulx D., Davidson A.R., and Maxwell K.L. 2015. The phage tail tape measure protein, an inner membrane protein, and a periplasmic chaperone play connected roles in the genome injection process of E. coli phage HK97. Mol. Microbiol. 96, 437-447.

Patin D., Bayliss M., Mengin-Lecreulx D., Oyston P., and Blanot D. 2015. Purification and biochemical characterisation of GlmU from Yersinia pestis. Arch. Microbiol. 197, 371-378.

Lipski A., Hervé M., Lombard V., Nurizzo D., Mengin-Lecreulx D., Bourne Y., and Vincent F. 2015. Structural and biochemical characterization of the β-N-acetylglucosaminidase from Thermotoga maritima : toward rationalization of mechanistic knowledge in the GH73 family. Glycobiology 25, 319-330.

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Dominique MENGIN-LECREULX : Présentation de l’équipe

Notre laboratoire développe une étude générale approfondie de la structure et du métabolisme du peptidoglycane, un des principaux constituants de la paroi bactérienne. Cette macromolécule (...)

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