Structural Biochemistry of Microtubules, Kinesins
and their Cargos

Our group mainly focuses on microtubule cytoskeleton and on their molecular motors kinesins.

Overview

The cytoskeleton of eukaryotic cells comprises several types of filaments, including actin filaments and microtubules. It is involved in many fundamental processes such as cell division or intracellular trafficking. In this last case, it forms “tracks” along which molecular motors move to transport across the cell various types of cargos (vesicles, nucleic acids, organelles, protein complexes…). Our group focuses on microtubules, on kinesins molecular motors, and on protein cargos recruited by these latter. Not surprisingly, dysfunctions of microtubule-based proteins are linked to a number of pathologies, including cancers, neurodegenerative disorders and ciliopathies.

 

More recently, we have initiated a project to characterize the origins and evolution of small G proteins of the Arf family.

 

We develop integrative structural biology to study these questions at atomic and macromolecular assembly scales.

Topics

team

Benoît GIGANT

Group Leader

Research Director

Julie MENETREY

Group Leader

Research Director

Marcel KNOSSOW

Emeritus Researcher

Louis RENAULT

Researcher

Paola LLINAS GARCIA

Researcher

Martine COMISSO

Researcher

Valérie CAMPANACCI

Engineer

Roxanne CHEVREAU

Engineer

Liza AMMAR-KHODJA

PhD student

Aysuna CORREIA

Intern student

Magda TEIXEIRA NUNES

PhD student

Latest publications

For all the publications of the Team click on the button below.

External Funding

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