Institute for Integrative Biology of the Cell

Moindrot Genomes

May 13rd, 2024 by Genome Biology Dept

Imprinting gene regulation: Importance of a long non-coding RNA and of DNA methylation levels at an essential CTCF binding site
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The Dlk1-Meg3-Dio3 domain is imprinted. Scientists at the IGMM and the I2BC have determined that Meg3 long non-coding RNA, as well as DNA methylation levels at an essential CTCF binding site in the domain, control Dlk1 imprinting in cis.

Ochsenbein B3S

April 12th, 2024 by B3S Dept

Epigenetics: combining flexible and rigid regions into a single structure to ensure genome replication and stability
The AMIG team at I2BC, in collaboration with teams from the Institut Curie and the Synchrotron Soleil, shows that the CAF-1 protein combines in its spatial organization flexible regions and rigid modules to deposit histones on DNA and effectively couple this process to DNA synthesis.
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Montagne Biocell

April 12th, 2024 by BioCell Dept

A Fatty Acid Anabolic Pathway in Specialized-Cells Sustains a Remote Signal that Controls Egg Activation in Drosophila
While egg activation, i.e. oocyte to embryo transition, was not known to depend on physiological non-genital signal, this study shows that in Drosophila it depends on a very-long-chain-fatty-acid produced in the oenocytes (lipid metabolism specialized cells).
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Betermier Genomes

April 12th, 2024 by Genome Biology Dept

Uncoupling programmed DNA cleavage and repair
scrambles the Paramecium somatic genome
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No Ku – no cut: how the ciliate Paramecium tetraurelia protects its somatic genome from translocations and aberrant chromosome fragmentation during developmentally programmed rearrangements.

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