Institute for Integrative Biology of the Cell

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NAMY MORIS GENOMES VIRO
Ribosome profiling and immunopeptidomics reveal tens of novel conserved HIV-1 ORF encoding T cell antigens

This study sheds light on an alternative mode of Transposable Element silencing associated with H3K27me3 instead of DNA methylation in flowering plants; it also indicates dynamic switching between the two epigenetic marks at the species level, a new paradigm that might extend to other multicellular eukaryotes

DELERIS GENOMES

march 12th, 2025 by Genome Biology Dept

Alternative silencing states of transposable elements in Arabidopsis associated with H3K27me3

This study sheds light on an alternative mode of Transposable Element silencing associated with H3K27me3 instead of DNA methylation in flowering plants; it also indicates dynamic switching between the two epigenetic marks at the species level, a new paradigm that might extend to other multicellular eukaryotes

NOORDERMEER GENOMES VIRO

march 12th, 2025 by Genome Biology Dept

Researchers at the I2BC and the Ecole Normale Supérieure found that the borders that create separation between functional domains in our chromosomes have an unexpectedly large influence on those domains themselves

Chromosomes in humans and other mammals are subdivided into “functional neighborhoods” that guide the fidelity of biological processes, including gene regulation and DNA repair. Perturbations of these neighborhoods, resulting in the fusion of adjacent domains, can lead to a variety of diseases, including cancer and developmental disorders.

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The I2BC is concerned by the future of scientists in the United States, with whom its teams collaborate closely.

The I2BC stands in solidarity with the Stand Up For Science movement and all scientists working in the USA, where academic freedom is currently being called into question.

The I2BC wishes to recall the importance of science and progress in today’s world, where we are faced with numerous societal challenges and crises.

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