Institute for Integrative Biology of the Cell
December 11th, 2024 by Microbio Dept
Dual RNA-seq study of the dynamics of coding and non-coding RNA expression during Clostridioides difficile infection in a mouse model
First adaptation of in vivo dual transcriptomics to human enteropathogen C. difficile revealed dynamics of gene expression in pathogen, its host, and gut microbiota composition and identified the novel RNA components shaping C. difficile virulence and host response.
December 11th, 2024 by B3S Dept
DciA, the Bacterial Replicative Helicase Loader, promotes LLPS in the presence of ssDNA
This study shows that DciA, the bacterial replicative helicase loader, promotes condensates in the presence of DNA. This opens the way to the possibility of non-membrane compartments in bacteria. The goal could be to concentrate the players involved in replication and thus facilitate it.
December 11th, 2024 by Genome Biology Dept
Ribosome composition plays a key role in EMT
Ribosome remodeling drives cancer cell transformation: A single protein, RPL36A, triggers EMT.
December 11th, 2024 by B3S Dept
The structure of a Tau fragment bound to tubulin prompts new hypotheses on Tau mechanism and oligomerization
We have identified a novel tubulin surface targeted by the Tau protein. From these results, we formulate new hypotheses on the regulation of microtubules by Tau and on Tau oligomerization.
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