Institute for Integrative Biology of the Cell
Publications
Publications / year
0
different journals
0
fields
0
Publications / year
0
different journals
0
fields
0
Latest Publications
3888256
i2bc
1
chicago-author-date
10
date
desc
year
4613
https://www.i2bc.paris-saclay.fr/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22TREG7D2H%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Meza-Torres%20et%20al.%22%2C%22parsedDate%22%3A%222025-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMeza-Torres%2C%20Jazmin%2C%20Jean-Yves%20Tinevez%2C%20Aline%20Crouzols%2C%20H%26%23xE9%3Blo%26%23xEF%3Bse%20Mary%2C%20Minhee%20Kim%2C%20Lise%20Hunault%2C%20Susan%20Chamorro-Rodriguez%2C%20et%20al.%202025.%20%26%23x201C%3BClostridioides%20Difficile%20Binary%20Toxin%20CDT%20Induces%20Biofilm-like%20Persisting%20Microcolonies.%26%23x201D%3B%20%3Ci%3EGut%20Microbes%3C%5C%2Fi%3E%2017%20%281%29%3A%202444411.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F19490976.2024.2444411%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F19490976.2024.2444411%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Clostridioides%20difficile%20binary%20toxin%20CDT%20induces%20biofilm-like%20persisting%20microcolonies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jazmin%22%2C%22lastName%22%3A%22Meza-Torres%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Yves%22%2C%22lastName%22%3A%22Tinevez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aline%22%2C%22lastName%22%3A%22Crouzols%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9lo%5Cu00efse%22%2C%22lastName%22%3A%22Mary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Minhee%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lise%22%2C%22lastName%22%3A%22Hunault%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susan%22%2C%22lastName%22%3A%22Chamorro-Rodriguez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emilie%22%2C%22lastName%22%3A%22Lejal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pamela%22%2C%22lastName%22%3A%22Altamirano-Silva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D%5Cu00e9borah%22%2C%22lastName%22%3A%22Groussard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samy%22%2C%22lastName%22%3A%22Gobaa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johann%22%2C%22lastName%22%3A%22Peltier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benoit%22%2C%22lastName%22%3A%22Chassaing%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Dupuy%22%7D%5D%2C%22abstractNote%22%3A%22Clinical%20symptoms%20of%20Clostridioides%20difficile%20infection%20%28CDI%29%20range%20from%20diarrhea%20to%20pseudomembranous%20colitis.%20A%20major%20challenge%20in%20managing%20CDI%20is%20the%20high%20rate%20of%20relapse.%20Several%20studies%20correlate%20the%20production%20of%20CDT%20binary%20toxin%20by%20clinical%20strains%20of%20C.%20difficile%20with%20higher%20relapse%20rates.%20Although%20the%20mechanism%20of%20action%20of%20CDT%20on%20host%20cells%20is%20known%2C%20its%20exact%20contribution%20to%20CDI%20is%20still%20unclear.%20To%20understand%20the%20physiological%20role%20of%20CDT%20during%20CDI%2C%20we%20established%20two%20hypoxic%20relevant%20intestinal%20models%2C%20Transwell%20and%20Microfluidic%20Intestine-on-Chip%20systems.%20Both%20were%20challenged%20with%20the%20epidemic%20strain%20UK1%20CDT%2B%20and%20its%20isogenic%20CDT-%20mutant.%20We%20report%20that%20CDT%20induces%20mucin-associated%20microcolonies%20that%20increase%20C.%20difficile%20colonization%20and%20display%20biofilm-like%20properties%20by%20enhancing%20C.%20difficile%20resistance%20to%20vancomycin.%20Importantly%2C%20biofilm-like%20microcolonies%20were%20also%20observed%20in%20the%20cecum%20and%20colon%20of%20infected%20mice.%20Hence%2C%20our%20study%20shows%20that%20CDT%20induces%20biofilm-like%20microcolonies%2C%20increasing%20C.%20difficile%20persistence%20and%20risk%20of%20relapse.%22%2C%22date%22%3A%222025-12%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1080%5C%2F19490976.2024.2444411%22%2C%22ISSN%22%3A%221949-0984%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-01-07T09%3A54%3A07Z%22%7D%7D%2C%7B%22key%22%3A%22C9ZGW5NN%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22James%20et%20al.%22%2C%22parsedDate%22%3A%222025-02%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EJames%2C%20John%2C%20Artem%20I.%20Fokin%2C%20Dmitry%20Y.%20Guschin%2C%20Hong%20Wang%2C%20Anna%20Polesskaya%2C%20Svetlana%20N.%20Rubtsova%2C%20Christophe%20Le%20Clainche%2C%20Pascal%20Silberzan%2C%20Alexis%20M.%20Gautreau%2C%20and%20St%26%23xE9%3Bphane%20Romero.%202025.%20%26%23x201C%3BVinculin-Arp2%5C%2F3%20Interaction%20Inhibits%20Branched%20Actin%20Assembly%20to%20Control%20Migration%20and%20Proliferation.%26%23x201D%3B%20%3Ci%3ELife%20Science%20Alliance%3C%5C%2Fi%3E%208%20%282%29%3A%20e202402583.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.26508%5C%2Flsa.202402583%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.26508%5C%2Flsa.202402583%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Vinculin-Arp2%5C%2F3%20interaction%20inhibits%20branched%20actin%20assembly%20to%20control%20migration%20and%20proliferation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%22%2C%22lastName%22%3A%22James%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Artem%20I.%22%2C%22lastName%22%3A%22Fokin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dmitry%20Y.%22%2C%22lastName%22%3A%22Guschin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hong%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22Polesskaya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Svetlana%20N.%22%2C%22lastName%22%3A%22Rubtsova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%20Le%22%2C%22lastName%22%3A%22Clainche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascal%22%2C%22lastName%22%3A%22Silberzan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%20M.%22%2C%22lastName%22%3A%22Gautreau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phane%22%2C%22lastName%22%3A%22Romero%22%7D%5D%2C%22abstractNote%22%3A%22Vinculin%20is%20a%20mechanotransducer%20that%20reinforces%20links%20between%20cell%20adhesions%20and%20linear%20arrays%20of%20actin%20filaments%20upon%20myosin-mediated%20contractility.%20Both%20adhesions%20to%20the%20substratum%20and%20neighboring%20cells%2C%20however%2C%20are%20initiated%20within%20membrane%20protrusions%20that%20originate%20from%20Arp2%5C%2F3-nucleated%20branched%20actin%20networks.%20Vinculin%20has%20been%20reported%20to%20interact%20with%20the%20Arp2%5C%2F3%20complex%2C%20but%20the%20role%20of%20this%20interaction%20remains%20poorly%20understood.%20Here%2C%20we%20compared%20the%20phenotypes%20of%20vinculin%20knock-out%20%28KO%29%20cells%20with%20those%20of%20knock-in%20%28KI-P878A%29%20cells%2C%20where%20the%20point%20mutation%20P878A%20that%20impairs%20the%20Arp2%5C%2F3%20interaction%20is%20introduced%20in%20the%20two%20vinculin%20alleles%20of%20MCF10A%20mammary%20epithelial%20cells.%20The%20interaction%20of%20vinculin%20with%20Arp2%5C%2F3%20inhibits%20actin%20polymerization%20at%20membrane%20protrusions%20and%20decreases%20migration%20persistence%20of%20single%20cells.%20In%20cell%20monolayers%2C%20vinculin%20recruits%20Arp2%5C%2F3%20and%20the%20vinculin-Arp2%5C%2F3%20interaction%20participates%20in%20cell-cell%20junction%20plasticity.%20Through%20this%20interaction%2C%20vinculin%20controls%20the%20decision%20to%20enter%20a%20new%20cell%20cycle%20as%20a%20function%20of%20cell%20density.%22%2C%22date%22%3A%222025-02%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.26508%5C%2Flsa.202402583%22%2C%22ISSN%22%3A%222575-1077%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-11-18T07%3A36%3A24Z%22%7D%7D%2C%7B%22key%22%3A%22YHFSCU4X%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Boussac%20et%20al.%22%2C%22parsedDate%22%3A%222025-01-15%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBoussac%2C%20Alain%2C%20Julien%20Sell%26%23xE9%3Bs%2C%20and%20Miwa%20Sugiura.%202025.%20%26%23x201C%3BKinetics%20of%20Reformation%20of%20the%20S0%20State%20Capable%20of%20Progressing%20to%20the%20S1%20State%20after%20the%20O2%20Release%20by%20Photosystem%20II.%26%23x201D%3B%20%3Ci%3EPhotosynthesis%20Research%3C%5C%2Fi%3E%20163%20%281%29%3A%205.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs11120-024-01131-4%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs11120-024-01131-4%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Kinetics%20of%20reformation%20of%20the%20S0%20state%20capable%20of%20progressing%20to%20the%20S1%20state%20after%20the%20O2%20release%20by%20photosystem%20II%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alain%22%2C%22lastName%22%3A%22Boussac%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Sell%5Cu00e9s%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miwa%22%2C%22lastName%22%3A%22Sugiura%22%7D%5D%2C%22abstractNote%22%3A%22The%20active%20site%20for%20water%20oxidation%20in%20photosystem%20II%20%28PSII%29%20comprises%20a%20Mn4CaO5%20cluster%20adjacent%20to%20a%20redox-active%20tyrosine%20residue%20%28TyrZ%29.%20During%20the%20water-splitting%20process%2C%20the%20enzyme%20transitions%20through%20five%20sequential%20oxidation%20states%20%28S0%20to%20S4%29%2C%20with%20O2%20evolution%20occurring%20during%20the%20S3TyrZ%5Cu00b7%20to%20S0TyrZ%20transition.%20Chloride%20also%20plays%20a%20role%20in%20this%20mechanism.%20Using%20PSII%20from%20Thermosynechococcus%20vestitus%2C%20where%20Ca%20and%20Cl%20were%20replaced%20with%20Sr%20and%20Br%20to%20slow%20the%20S3TyrZ%5Cu00b7%20to%20S0TyrZ%5Cu2009%2B%5Cu2009O2%20transition%20%28t1%5C%2F2%5Cu2009~%5Cu20095%5Cu00a0ms%20at%20room%20temperature%29%2C%20it%20was%20observed%20that%20the%20recovery%20of%20a%20S0%20state%2C%20defined%20as%20the%20state%20able%20to%20progress%20to%20S1%2C%20exhibits%20similar%20kinetics%20%28t1%5C%2F2%5Cu2009~%5Cu20095%5Cu00a0ms%29.%20This%20suggests%20that%20in%20CaCl-PSII%2C%20the%20reformation%20of%20the%20functional%20S0%20state%20directly%20follows%20the%20S3TyrZ%5Cu00b7%20to%20S0TyrZ%5Cu2009%2B%5Cu2009O2%20transition%2C%20with%20no%20additional%20delay%20required%20for%20the%20insertion%20of%20a%20new%20substrate%20water%20molecule%20%28O5%29%20and%20associated%20protons.%22%2C%22date%22%3A%222025-01-15%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs11120-024-01131-4%22%2C%22ISSN%22%3A%221573-5079%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-01-16T14%3A45%3A33Z%22%7D%7D%2C%7B%22key%22%3A%225TXWI7KR%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fruchard%20et%20al.%22%2C%22parsedDate%22%3A%222025-01-06%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EFruchard%2C%20Louna%2C%20Anamaria%20Babosan%2C%20Andre%20Carvalho%2C%20Manon%20Lang%2C%20Blaise%20Li%2C%20Magalie%20Duchateau%2C%20Quentin%20Giai%20Gianetto%2C%20et%20al.%202025.%20%26%23x201C%3BAminoglycoside%20Tolerance%20in%20Vibrio%20Cholerae%20Engages%20Translational%20Reprogramming%20Associated%20with%20Queuosine%20TRNA%20Modification.%26%23x201D%3B%20%3Ci%3EELife%3C%5C%2Fi%3E%2013%20%28January%29%3ARP96317.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.7554%5C%2FeLife.96317%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.7554%5C%2FeLife.96317%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Aminoglycoside%20tolerance%20in%20Vibrio%20cholerae%20engages%20translational%20reprogramming%20associated%20with%20queuosine%20tRNA%20modification%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Louna%22%2C%22lastName%22%3A%22Fruchard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anamaria%22%2C%22lastName%22%3A%22Babosan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andre%22%2C%22lastName%22%3A%22Carvalho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manon%22%2C%22lastName%22%3A%22Lang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Blaise%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Magalie%22%2C%22lastName%22%3A%22Duchateau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Giai%20Gianetto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariette%22%2C%22lastName%22%3A%22Matondo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frederic%22%2C%22lastName%22%3A%22Bonhomme%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Hatin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugo%22%2C%22lastName%22%3A%22Arbes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00e9line%22%2C%22lastName%22%3A%22Fabret%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Enora%22%2C%22lastName%22%3A%22Corler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Sanchez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Virginie%22%2C%22lastName%22%3A%22Marchand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuri%22%2C%22lastName%22%3A%22Motorin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Namy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9rie%22%2C%22lastName%22%3A%22de%20Cr%5Cu00e9cy-Lagard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Didier%22%2C%22lastName%22%3A%22Mazel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zeynep%22%2C%22lastName%22%3A%22Baharoglu%22%7D%5D%2C%22abstractNote%22%3A%22Tgt%20is%20the%20enzyme%20modifying%20the%20guanine%20%28G%29%20in%20tRNAs%20with%20GUN%20anticodon%20to%20queuosine%20%28Q%29.%20tgt%20is%20required%20for%20optimal%20growth%20of%20Vibrio%20cholerae%20in%20the%20presence%20of%20sub-lethal%20aminoglycoside%20concentrations.%20We%20further%20explored%20here%20the%20role%20of%20the%20Q34%20in%20the%20efficiency%20of%20codon%20decoding%20upon%20tobramycin%20exposure.%20We%20characterized%20its%20impact%20on%20the%20overall%20bacterial%20proteome%2C%20and%20elucidated%20the%20molecular%20mechanisms%20underlying%20the%20effects%20of%20Q34%20modification%20in%20antibiotic%20translational%20stress%20response.%20Using%20molecular%20reporters%2C%20we%20showed%20that%20Q34%20impacts%20the%20efficiency%20of%20decoding%20at%20tyrosine%20TAT%20and%20TAC%20codons.%20Proteomics%20analyses%20revealed%20that%20the%20anti-SoxR%20factor%20RsxA%20is%20better%20translated%20in%20the%20absence%20of%20tgt.%20RsxA%20displays%20a%20codon%20bias%20toward%20tyrosine%20TAT%20and%20overabundance%20of%20RsxA%20leads%20to%20decreased%20expression%20of%20genes%20belonging%20to%20SoxR%20oxidative%20stress%20regulon.%20We%20also%20identified%20conditions%20that%20regulate%20tgt%20expression.%20We%20propose%20that%20regulation%20of%20Q34%20modification%20in%20response%20to%20environmental%20cues%20leads%20to%20translational%20reprogramming%20of%20transcripts%20bearing%20a%20biased%20tyrosine%20codon%20usage.%20In%20silico%20analysis%20further%20identified%20candidate%20genes%20which%20could%20be%20subject%20to%20such%20translational%20regulation%2C%20among%20which%20DNA%20repair%20factors.%20Such%20transcripts%2C%20fitting%20the%20definition%20of%20modification%20tunable%20transcripts%2C%20are%20central%20in%20the%20bacterial%20response%20to%20antibiotics.%22%2C%22date%22%3A%222025-01-06%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.7554%5C%2FeLife.96317%22%2C%22ISSN%22%3A%222050-084X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-01-07T10%3A29%3A54Z%22%7D%7D%2C%7B%22key%22%3A%22REHZZC5N%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Novikov%20et%20al.%22%2C%22parsedDate%22%3A%222025-01-02%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ENovikov%2C%20Nikita%20M.%2C%20Jinmei%20Gao%2C%20Artem%20I.%20Fokin%2C%20Nathalie%20Rocques%2C%20Giovanni%20Chiappetta%2C%20Karina%20D.%20Rysenkova%2C%20Diego%20Javier%20Zea%2C%20et%20al.%202025.%20%26%23x201C%3BNHSL3%20Controls%20Single%20and%20Collective%20Cell%20Migration%20through%20Two%20Distinct%20Mechanisms.%26%23x201D%3B%20%3Ci%3ENature%20Communications%3C%5C%2Fi%3E%2016%20%281%29%3A%20205.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-024-55647-3%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-024-55647-3%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22NHSL3%20controls%20single%20and%20collective%20cell%20migration%20through%20two%20distinct%20mechanisms%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nikita%20M.%22%2C%22lastName%22%3A%22Novikov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jinmei%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Artem%20I.%22%2C%22lastName%22%3A%22Fokin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Rocques%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giovanni%22%2C%22lastName%22%3A%22Chiappetta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karina%20D.%22%2C%22lastName%22%3A%22Rysenkova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Diego%20Javier%22%2C%22lastName%22%3A%22Zea%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22Polesskaya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joelle%22%2C%22lastName%22%3A%22Vinh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raphael%22%2C%22lastName%22%3A%22Guerois%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%20M.%22%2C%22lastName%22%3A%22Gautreau%22%7D%5D%2C%22abstractNote%22%3A%22The%20molecular%20mechanisms%20underlying%20cell%20migration%20remain%20incompletely%20understood.%20Here%2C%20we%20show%20that%20knock-out%20cells%20for%20NHSL3%2C%20the%20most%20recently%20identified%20member%20of%20the%20Nance-Horan%20Syndrome%20family%2C%20are%20more%20persistent%20than%20parental%20cells%20in%20single%20cell%20migration%2C%20but%20that%2C%20in%20wound%20healing%2C%20follower%20cells%20are%20impaired%20in%20their%20ability%20to%20follow%20leader%20cells.%20The%20NHSL3%20locus%20encodes%20several%20isoforms.%20We%20identify%20the%20partner%20repertoire%20of%20each%20isoform%20using%20proteomics%20and%20predict%20direct%20partners%20and%20their%20binding%20sites%20using%20an%20AlphaFold2-based%20pipeline.%20Rescue%20with%20specific%20isoforms%2C%20and%20lack%20of%20rescue%20when%20relevant%20binding%20sites%20are%20mutated%2C%20establish%20that%20the%20interaction%20of%20a%20long%20isoform%20with%20MENA%5C%2FVASP%20proteins%20is%20critical%20at%20cell-cell%20junctions%20for%20collective%20migration%2C%20while%20the%20interaction%20of%20a%20short%20one%20with%2014-3-3%5Cu03b8%20in%20lamellipodia%20is%20critical%20for%20single%20cell%20migration.%20Taken%20together%2C%20these%20results%20demonstrate%20that%20NHSL3%20regulates%20single%20and%20collective%20cell%20migration%20through%20distinct%20mechanisms.%22%2C%22date%22%3A%222025-01-02%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41467-024-55647-3%22%2C%22ISSN%22%3A%222041-1723%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-01-07T09%3A53%3A09Z%22%7D%7D%2C%7B%22key%22%3A%22SG9DDAIK%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Villain%20and%20Basta%22%2C%22parsedDate%22%3A%222024-12-22%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EVillain%2C%20Paul%2C%20and%20Tamara%20Basta.%202024.%20%26%23x201C%3BRegulation%20of%20DNA%20Topology%20in%20Archaea%3A%20State%20of%20the%20Art%20and%20Perspectives.%26%23x201D%3B%20%3Ci%3EMolecular%20Microbiology%3C%5C%2Fi%3E%2C%20December.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fmmi.15328%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fmmi.15328%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Regulation%20of%20DNA%20Topology%20in%20Archaea%3A%20State%20of%20the%20Art%20and%20Perspectives%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Villain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Basta%22%7D%5D%2C%22abstractNote%22%3A%22DNA%20topology%20is%20a%20direct%20consequence%20of%20the%20double%20helical%20nature%20of%20DNA%20and%20is%20defined%20by%20how%20the%20two%20complementary%20DNA%20strands%20are%20intertwined.%20Virtually%20every%20reaction%20involving%20DNA%20is%20influenced%20by%20DNA%20topology%20or%20has%20topological%20effects.%20It%20is%20therefore%20of%20fundamental%20importance%20to%20understand%20how%20this%20phenomenon%20is%20controlled%20in%20living%20cells.%20DNA%20topoisomerases%20are%20the%20key%20actors%20dedicated%20to%20the%20regulation%20of%20DNA%20topology%20in%20cells%20from%20all%20domains%20of%20life.%20While%20significant%20progress%20has%20been%20made%20in%20the%20last%20two%20decades%20in%20understanding%20how%20these%20enzymes%20operate%20in%5Cu00a0vivo%20in%20Bacteria%20and%20Eukaryotes%2C%20studies%20in%20Archaea%20have%20been%20lagging%20behind.%20This%20review%20article%20aims%20to%20summarize%20what%20is%20currently%20known%20about%20DNA%20topology%20regulation%20by%20DNA%20topoisomerases%20in%20main%20archaeal%20model%20organisms.%20These%20model%20archaea%20exhibit%20markedly%20different%20lifestyles%2C%20genome%20organization%20and%20topoisomerase%20content%2C%20thus%20highlighting%20the%20diversity%20and%20the%20complexity%20of%20DNA%20topology%20regulation%20mechanisms%20and%20their%20evolution%20in%20this%20domain%20of%20life.%20The%20recent%20development%20of%20functional%20genomic%20assays%20supported%20by%20next-generation%20sequencing%20now%20allows%20to%20delve%20deeper%20into%20this%20timely%20and%20exciting%2C%20yet%20still%20understudied%20topic.%22%2C%22date%22%3A%222024-12-22%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1111%5C%2Fmmi.15328%22%2C%22ISSN%22%3A%221365-2958%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-12-23T08%3A09%3A57Z%22%7D%7D%2C%7B%22key%22%3A%22Q4H638I7%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Marceau%20et%20al.%22%2C%22parsedDate%22%3A%222024-12-20%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMarceau%2C%20Fanny%2C%20Marl%26%23xE8%3Bne%20Lamothe-Sibold%2C%20Sandrine%20Farci%2C%20Soufian%20Ouchane%2C%20Corinne%20Cassier-Chauvat%2C%20and%20Franck%20Chauvat.%202024.%20%26%23x201C%3BFirst%20Characterization%20of%20a%20Cyanobacterial%20Xi-Class%20Glutathione%20S-Transferase%20in%20Synechocystis%20PCC%206803.%26%23x201D%3B%20%3Ci%3EAntioxidants%20%28Basel%2C%20Switzerland%29%3C%5C%2Fi%3E%2013%20%2812%29%3A%201577.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fantiox13121577%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fantiox13121577%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22First%20Characterization%20of%20a%20Cyanobacterial%20Xi-Class%20Glutathione%20S-Transferase%20in%20Synechocystis%20PCC%206803%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fanny%22%2C%22lastName%22%3A%22Marceau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marl%5Cu00e8ne%22%2C%22lastName%22%3A%22Lamothe-Sibold%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Farci%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Soufian%22%2C%22lastName%22%3A%22Ouchane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Corinne%22%2C%22lastName%22%3A%22Cassier-Chauvat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Franck%22%2C%22lastName%22%3A%22Chauvat%22%7D%5D%2C%22abstractNote%22%3A%22Glutathione%20S-transferases%20%28GSTs%29%20are%20evolutionarily%20conserved%20enzymes%20crucial%20for%20cell%20detoxication.%20They%20are%20viewed%20as%20having%20evolved%20in%20cyanobacteria%2C%20the%20ancient%20photosynthetic%20prokaryotes%20that%20colonize%20our%20planet%20and%20play%20a%20crucial%20role%20for%20its%20biosphere.%20Xi-class%20GSTs%2C%20characterized%20by%20their%20specific%20glutathionyl-hydroquinone%20reductase%20activity%2C%20have%20been%20observed%20in%20prokaryotes%2C%20fungi%20and%20plants%2C%20but%20have%20not%20yet%20been%20studied%20in%20cyanobacteria.%20In%20this%20study%2C%20we%20have%20analyzed%20the%20presumptive%20Xi-class%20GST%2C%20designated%20as%20Slr0605%2C%20of%20the%20unicellular%20model%20cyanobacterium%20Synechocystis%20PCC%206803.%20We%20report%20that%20Slr0605%20is%20a%20homodimeric%20protein%20that%20has%20genuine%20glutathionyl-hydroquinone%20reductase%20activity.%20Though%20Slr0605%20is%20not%20essential%20for%20cell%20growth%20under%20standard%20photoautotrophic%20conditions%2C%20it%20plays%20a%20prominent%20role%20in%20the%20protection%20against%20not%20only%20benzoquinone%2C%20but%20also%20cobalt-excess%20stress.%20Indeed%2C%20Slr0605%20acts%20in%20defense%20against%20the%20cobalt-elicited%20disturbances%20of%20iron%20homeostasis%2C%20iron-sulfur%20cluster%20repair%2C%20catalase%20activity%20and%20the%20level%20of%20reactive%20oxygen%20species%2C%20which%20are%20all%20crucial%20for%20cell%20life.%22%2C%22date%22%3A%222024-12-20%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.3390%5C%2Fantiox13121577%22%2C%22ISSN%22%3A%222076-3921%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-01-09T08%3A19%3A53Z%22%7D%7D%2C%7B%22key%22%3A%22CZC349S8%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Morin%20et%20al.%22%2C%22parsedDate%22%3A%222024-12-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMorin%2C%20Chlo%26%23xE9%3B%2C%20Agn%26%23xE8%3Bs%20Baudin-Baillieu%2C%20Flora%20Nguyen%20Van%20Long%2C%20Caroline%20Isaac%2C%20Laure%20Bidou%2C%20Hugo%20Arbes%2C%20Pauline%20Fran%26%23xE7%3Bois%2C%20et%20al.%202024.%20%26%23x201C%3BIntricate%20Ribosome%20Composition%20and%20Translational%20Reprogramming%20in%20Epithelial-Mesenchymal%20Transition.%26%23x201D%3B%20%3Ci%3EProceedings%20of%20the%20National%20Academy%20of%20Sciences%20of%20the%20United%20States%20of%20America%3C%5C%2Fi%3E%20121%20%2850%29%3A%20e2408114121.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1073%5C%2Fpnas.2408114121%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1073%5C%2Fpnas.2408114121%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Intricate%20ribosome%20composition%20and%20translational%20reprogramming%20in%20epithelial-mesenchymal%20transition%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chlo%5Cu00e9%22%2C%22lastName%22%3A%22Morin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agn%5Cu00e8s%22%2C%22lastName%22%3A%22Baudin-Baillieu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Flora%20Nguyen%22%2C%22lastName%22%3A%22Van%20Long%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Isaac%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laure%22%2C%22lastName%22%3A%22Bidou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugo%22%2C%22lastName%22%3A%22Arbes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pauline%22%2C%22lastName%22%3A%22Fran%5Cu00e7ois%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roxane%20M.%22%2C%22lastName%22%3A%22Pommier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annie%22%2C%22lastName%22%3A%22Adrait%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Akari%22%2C%22lastName%22%3A%22Saku%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%22%2C%22lastName%22%3A%22Gran-Ruaz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cam%5Cu00e9lia%22%2C%22lastName%22%3A%22Machkouri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Vanbelle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Morichon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathieu%22%2C%22lastName%22%3A%22Boissan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fr%5Cu00e9d%5Cu00e9ric%22%2C%22lastName%22%3A%22Catez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anthony%22%2C%22lastName%22%3A%22Ferrari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Pierre%22%2C%22lastName%22%3A%22Morel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yohann%22%2C%22lastName%22%3A%22Cout%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Chat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuel%22%2C%22lastName%22%3A%22Giudice%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reynald%22%2C%22lastName%22%3A%22Gillet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alain%22%2C%22lastName%22%3A%22Puisieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Moyret-Lalle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Jacques%22%2C%22lastName%22%3A%22Diaz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Namy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Virginie%22%2C%22lastName%22%3A%22Marcel%22%7D%5D%2C%22abstractNote%22%3A%22Epithelial-mesenchymal%20transition%20%28EMT%29%20involves%20profound%20changes%20in%20cell%20morphology%2C%20driven%20by%20transcriptional%20and%20epigenetic%20reprogramming.%20However%2C%20evidence%20suggests%20that%20translation%20and%20ribosome%20composition%20also%20play%20key%20roles%20in%20establishing%20pathophysiological%20phenotypes.%20Using%20genome-wide%20analyses%2C%20we%20reported%20significant%20rearrangement%20of%20the%20translational%20landscape%20and%20machinery%20during%20EMT.%20Specifically%2C%20a%20cell%20line%20overexpressing%20the%20EMT%20transcription%20factor%20ZEB1%20displayed%20alterations%20in%20translational%20reprogramming%20and%20fidelity.%20Furthermore%2C%20using%20riboproteomics%2C%20we%20unveiled%20an%20increased%20level%20of%20the%20ribosomal%20protein%20RPL36A%20in%20mesenchymal%20ribosomes%2C%20indicating%20precise%20tuning%20of%20ribosome%20composition.%20Remarkably%2C%20RPL36A%20overexpression%20alone%20was%20sufficient%20to%20trigger%20the%20acquisition%20of%20mesenchymal%20features%2C%20including%20a%20switch%20in%20the%20molecular%20pattern%2C%20cell%20morphology%2C%20and%20behavior%2C%20demonstrating%20its%20pivotal%20role%20in%20EMT.%20These%20findings%20underline%20the%20importance%20of%20translational%20reprogramming%20and%20fine-tuning%20of%20ribosome%20composition%20in%20EMT.%22%2C%22date%22%3A%222024-12-10%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1073%5C%2Fpnas.2408114121%22%2C%22ISSN%22%3A%221091-6490%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-12-06T15%3A50%3A42Z%22%7D%7D%2C%7B%22key%22%3A%225AFXQZCP%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Crawford%20et%20al.%22%2C%22parsedDate%22%3A%222024-12-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ECrawford%2C%20Margaret%20R.%2C%20Jon%20A.%20Harper%2C%20Tim%20J.%20Cooper%2C%20Marie-Claude%20Marsolier-Kergoat%2C%20Bertrand%20Llorente%2C%20and%20Matthew%20J.%20Neale.%202024.%20%26%23x201C%3BSeparable%20Roles%20of%20the%20DNA%20Damage%20Response%20Kinase%20Mec1ATR%20and%20Its%20Activator%20Rad24RAD17%20during%20Meiotic%20Recombination.%26%23x201D%3B%20%3Ci%3EPLoS%20Genetics%3C%5C%2Fi%3E%2020%20%2812%29%3A%20e1011485.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgen.1011485%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgen.1011485%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Separable%20roles%20of%20the%20DNA%20damage%20response%20kinase%20Mec1ATR%20and%20its%20activator%20Rad24RAD17%20during%20meiotic%20recombination%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margaret%20R.%22%2C%22lastName%22%3A%22Crawford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jon%20A.%22%2C%22lastName%22%3A%22Harper%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tim%20J.%22%2C%22lastName%22%3A%22Cooper%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie-Claude%22%2C%22lastName%22%3A%22Marsolier-Kergoat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Llorente%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20J.%22%2C%22lastName%22%3A%22Neale%22%7D%5D%2C%22abstractNote%22%3A%22During%20meiosis%2C%20programmed%20DNA%20double-strand%20breaks%20%28DSBs%29%20are%20formed%20by%20the%20topoisomerase-like%20enzyme%2C%20Spo11%2C%20activating%20the%20DNA%20damage%20response%20%28DDR%29%20kinase%20Mec1ATR%20via%20the%20checkpoint%20clamp%20loader%2C%20Rad24RAD17.%20At%20single%20loci%2C%20loss%20of%20Mec1%20and%20Rad24%20activity%20alters%20DSB%20formation%20and%20recombination%20outcome%2C%20but%20their%20genome-wide%20roles%20have%20not%20been%20examined%20in%20detail.%20Here%2C%20we%20utilise%20two%20strategies-deletion%20of%20the%20mismatch%20repair%20protein%2C%20Msh2%2C%20and%20control%20of%20meiotic%20prophase%20length%20via%20regulation%20of%20the%20Ndt80%20transcription%20factor-to%20help%20characterise%20the%20roles%20Mec1%20and%20Rad24%20play%20in%20meiotic%20recombination%20by%20enabling%20genome-wide%20mapping%20of%20meiotic%20progeny.%20In%20line%20with%20previous%20studies%2C%20we%20observe%20severely%20impacted%20spore%20viability%20and%20a%20reduction%20in%20the%20frequency%20of%20recombination%20upon%20deletion%20of%20RAD24-driven%20by%20a%20shortened%20prophase.%20By%20contrast%2C%20loss%20of%20Mec1%20function%20increases%20recombination%20frequency%2C%20consistent%20with%20its%20role%20in%20DSB%20trans-interference%2C%20and%20has%20less%20effect%20on%20spore%20viability.%20Despite%20these%20differences%2C%20complex%20multi-chromatid%20events%20initiated%20by%20closely%20spaced%20DSBs-rare%20in%20wild-type%20cells-occur%20more%20frequently%20in%20the%20absence%20of%20either%20Rad24%20or%20Mec1%2C%20suggesting%20a%20loss%20of%20spatial%20regulation%20at%20the%20level%20of%20DSB%20formation%20in%20both.%20Mec1%20and%20Rad24%20also%20have%20important%20roles%20in%20the%20spatial%20regulation%20of%20crossovers%20%28COs%29.%20Upon%20loss%20of%20either%20Mec1%20or%20Rad24%2C%20CO%20distributions%20become%20more%20random-suggesting%20reductions%20in%20the%20global%20manifestation%20of%20interference.%20Such%20effects%20are%20similar%20to%2C%20but%20less%20extreme%20than%2C%20the%20phenotype%20of%20%27ZMM%27%20mutants%20such%20as%20zip3%5Cu0394%2C%20and%20may%20be%20driven%20by%20reductions%20in%20the%20proportion%20of%20interfering%20COs.%20Collectively%2C%20in%20addition%20to%20shared%20roles%20in%20CO%20regulation%2C%20our%20results%20highlight%20separable%20roles%20for%20Rad24%20as%20a%20pro-CO%20factor%2C%20and%20for%20Mec1%20as%20a%20regulator%20of%20recombination%20frequency%2C%20the%20loss%20of%20which%20helps%20to%20suppress%20any%20broader%20defects%20in%20CO%20regulation%20caused%20by%20abrogation%20of%20the%20DDR.%22%2C%22date%22%3A%222024-12-09%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pgen.1011485%22%2C%22ISSN%22%3A%221553-7404%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-12-10T07%3A35%3A15Z%22%7D%7D%2C%7B%22key%22%3A%223U88SMCN%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Magne%20et%20al.%22%2C%22parsedDate%22%3A%222024-12-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMagne%2C%20Chloe%2C%20Simona%20Streckaite%2C%20Roberto%20A.%20Boto%2C%20Eduardo%20Dom%26%23xED%3Bnguez-Ojeda%2C%20Marina%20Gromova%2C%20Andrea%20Echeverri%2C%20Flavio%20Siro%20Brigiano%2C%20et%20al.%202024.%20%26%23x201C%3BCorrection%3A%20Perylene-Derivative%20Singlet%20Exciton%20Fission%20in%20Water%20Solution.%26%23x201D%3B%20%3Ci%3EChemical%20Science%3C%5C%2Fi%3E%2C%20December.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1039%5C%2Fd4sc90232g%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1039%5C%2Fd4sc90232g%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Correction%3A%20Perylene-derivative%20singlet%20exciton%20fission%20in%20water%20solution%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chloe%22%2C%22lastName%22%3A%22Magne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simona%22%2C%22lastName%22%3A%22Streckaite%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roberto%20A.%22%2C%22lastName%22%3A%22Boto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eduardo%22%2C%22lastName%22%3A%22Dom%5Cu00ednguez-Ojeda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marina%22%2C%22lastName%22%3A%22Gromova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Echeverri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Flavio%20Siro%22%2C%22lastName%22%3A%22Brigiano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Minh-Huong%22%2C%22lastName%22%3A%22Ha-Thi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marius%22%2C%22lastName%22%3A%22Franckevi%5Cu010dius%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vidmantas%22%2C%22lastName%22%3A%22Ja%5Cu0161inskas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annamaria%22%2C%22lastName%22%3A%22Quaranta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20A.%22%2C%22lastName%22%3A%22Pascal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthieu%22%2C%22lastName%22%3A%22Koepf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Casanova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Pino%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Contreras-Garc%5Cu00eda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Finkelstein-Shapiro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vidmantas%22%2C%22lastName%22%3A%22Gulbinas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manuel%20J.%22%2C%22lastName%22%3A%22Llansola-Portoles%22%7D%5D%2C%22abstractNote%22%3A%22%5BThis%20corrects%20the%20article%20DOI%3A%2010.1039%5C%2FD4SC04732J.%5D.%22%2C%22date%22%3A%222024-12-04%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1039%5C%2Fd4sc90232g%22%2C%22ISSN%22%3A%222041-6520%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-12-06T15%3A48%3A11Z%22%7D%7D%5D%7D
Meza-Torres, Jazmin, Jean-Yves Tinevez, Aline Crouzols, Héloïse Mary, Minhee Kim, Lise Hunault, Susan Chamorro-Rodriguez, et al. 2025. “Clostridioides Difficile Binary Toxin CDT Induces Biofilm-like Persisting Microcolonies.” Gut Microbes 17 (1): 2444411. https://doi.org/10.1080/19490976.2024.2444411.
James, John, Artem I. Fokin, Dmitry Y. Guschin, Hong Wang, Anna Polesskaya, Svetlana N. Rubtsova, Christophe Le Clainche, Pascal Silberzan, Alexis M. Gautreau, and Stéphane Romero. 2025. “Vinculin-Arp2/3 Interaction Inhibits Branched Actin Assembly to Control Migration and Proliferation.” Life Science Alliance 8 (2): e202402583. https://doi.org/10.26508/lsa.202402583.
Boussac, Alain, Julien Sellés, and Miwa Sugiura. 2025. “Kinetics of Reformation of the S0 State Capable of Progressing to the S1 State after the O2 Release by Photosystem II.” Photosynthesis Research 163 (1): 5. https://doi.org/10.1007/s11120-024-01131-4.
Fruchard, Louna, Anamaria Babosan, Andre Carvalho, Manon Lang, Blaise Li, Magalie Duchateau, Quentin Giai Gianetto, et al. 2025. “Aminoglycoside Tolerance in Vibrio Cholerae Engages Translational Reprogramming Associated with Queuosine TRNA Modification.” ELife 13 (January):RP96317. https://doi.org/10.7554/eLife.96317.
Novikov, Nikita M., Jinmei Gao, Artem I. Fokin, Nathalie Rocques, Giovanni Chiappetta, Karina D. Rysenkova, Diego Javier Zea, et al. 2025. “NHSL3 Controls Single and Collective Cell Migration through Two Distinct Mechanisms.” Nature Communications 16 (1): 205. https://doi.org/10.1038/s41467-024-55647-3.
Villain, Paul, and Tamara Basta. 2024. “Regulation of DNA Topology in Archaea: State of the Art and Perspectives.” Molecular Microbiology, December. https://doi.org/10.1111/mmi.15328.
Marceau, Fanny, Marlène Lamothe-Sibold, Sandrine Farci, Soufian Ouchane, Corinne Cassier-Chauvat, and Franck Chauvat. 2024. “First Characterization of a Cyanobacterial Xi-Class Glutathione S-Transferase in Synechocystis PCC 6803.” Antioxidants (Basel, Switzerland) 13 (12): 1577. https://doi.org/10.3390/antiox13121577.
Morin, Chloé, Agnès Baudin-Baillieu, Flora Nguyen Van Long, Caroline Isaac, Laure Bidou, Hugo Arbes, Pauline François, et al. 2024. “Intricate Ribosome Composition and Translational Reprogramming in Epithelial-Mesenchymal Transition.” Proceedings of the National Academy of Sciences of the United States of America 121 (50): e2408114121. https://doi.org/10.1073/pnas.2408114121.
Crawford, Margaret R., Jon A. Harper, Tim J. Cooper, Marie-Claude Marsolier-Kergoat, Bertrand Llorente, and Matthew J. Neale. 2024. “Separable Roles of the DNA Damage Response Kinase Mec1ATR and Its Activator Rad24RAD17 during Meiotic Recombination.” PLoS Genetics 20 (12): e1011485. https://doi.org/10.1371/journal.pgen.1011485.
Magne, Chloe, Simona Streckaite, Roberto A. Boto, Eduardo Domínguez-Ojeda, Marina Gromova, Andrea Echeverri, Flavio Siro Brigiano, et al. 2024. “Correction: Perylene-Derivative Singlet Exciton Fission in Water Solution.” Chemical Science, December. https://doi.org/10.1039/d4sc90232g.