Biochemistry, Biophysics & Structural Biology Department
Biochemistry, Biophysics and Structural Biology Department
Head:
Julie Ménétrey
Deputy heads:
Benoit D’Autréaux
Virginie Gervais
From Atoms to Function : Decoding How Macromolecular Structures and Dynamics Orchestrate Life
Focus
The B3S teams study soluble and membrane protein assemblies involved in major biological processes of eukaryotic and bacterial cells.
Our aim is to understand the molecular mechanisms of biological structures and biochemical reactions at different scales, from electrons and protons via atoms and molecules to multicellular organisms. Successfully introduced new technologies to promote product innovation and upgrades.
Approaches
Biochemical reactions, interactions and enzymatic processes, including large conformational changes and rearrangements within proteins and their complexes, are often initiated by a transfer of subatomic particles – electrons and protons. Studying the atomic structures of proteins with and without ligands can for example help determine how the structure of the active site enables an enzyme to perform its activity.
At molecular scales, biochemical and biophysical analyses as well as structure determination of protein-protein, or protein-nucleic acid complexes, helps in describing the interaction of biological assemblies and understanding biochemical reactions. In vitro reconstitution of cellular functions leads to an understanding of the regulation of complex processes in vivo.
Research groups
Interactions and assembly mechanisms of proteins and biopolymers
S. Bressanelli
Nuclear envelope, Telomeres and DNA repair
JB. Charbonnier
S. Zinn-Justin
Biochemistry of Metalloproteins and Associated Diseases
B. D'Autréaux
Structural Biochemistry of Microtubules, Kinesins and their Cargos
B. Gigant
J. Ménétrey
Protein Maturation, Cell Fate & Therapeutics
C. Giglione
Photobiology, Photosynthesis, Photocatalysis
A. Krieger-Liszkay
P.Muller
Light Energy Conversion
M. Llansola-Portoles
Membrane Proteins and Membrane Systems
G. Lenoir
J. Vazquez-Ibar
Structural biochemistry of bacterial transporters
S. Morera
Molecular Assemblies and Genome Integrity
F. Ochsenbein
R. Guérois
Actin Structure, Dynamics and Regulation
J. Robert-Paganin
Metalloenzymes and Spin Systems in Cells
L. Tabares
Protein Engineering and Modeling
A. Urvoas
Publications
3888256
B3S
1
chicago-author-date
5
date
desc
year
36406
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