Biochemistry, Biophysics & Structural Biology Department

Biochemistry, Biophysics and Structural Biology Department

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Director: 

 Sylvie Nessler

sylvie.nessler@i2BC.paris-saclay.fr 

Deputy  Directors:

dautreaut

    Benoit D’Autréaux 

benoit.dautreaux@I2BC.paris-saclay.fr

Julie Ménétrey

julie.menetrey@i2BC.paris-saclay.fr 

 Françoise Ochsenbein

françoise.ochsenbein@I2BC.paris-saclay.fr  

The department is interested in protein architectures and studies how their different structural levels and interactions regulate their functions.

Focus

The B3S teams study soluble and membrane protein assemblies involved in major biological processes of eukaryotic and bacterial cells. 

Our aim is to  understand the molecular mechanisms of biological structures and biochemical reactions at different scales, from electrons and protons via atoms and molecules to multicellular organisms. 

Approaches

Biochemical reactions, interactions and enzymatic processes, including large conformational changes and rearrangements within proteins and their complexes, are often initiated by a transfer of subatomic particles – electrons and protons. Studying the atomic structures of proteins with and without ligands can for example help determine how the structure of the active site enables an enzyme to perform its activity.

At molecular scales, biochemical and biophysical analyses as well as structure determination of protein-protein, or protein-nucleic acid complexes, helps in describing the interaction of biological assemblies and understanding biochemical reactions.  In vitro reconstitution of cellular functions leads to an understanding of the regulation of complex processes in vivo.

Research groups

Group Leader

A. URVOAS

Group Leaders

F. OCHSENBEIN & R. GUEROIS

Publications

Rossier, Ombeline, Cécile Labarre, Anne Lopes, Monique Auberdiac, Kevin Tambosco, Daniel Delaruelle, Hakima Abes, et al. 2024. “Genome Sequence of PSonyx, a Singleton Bacteriophage Infecting Corynebacterium Glutamicum.” Microbiology Resource Announcements, January, e0115523. https://doi.org/10.1128/mra.01155-23.
Magne, Chloe, Simona Streckaite, Roberto A. Boto, Eduardo Domínguez-Ojeda, Marina Gromova, Andrea Echeverri, Flavio Siro Brigiano, et al. 2024. “Correction: Perylene-Derivative Singlet Exciton Fission in Water Solution.” Chemical Science, December. https://doi.org/10.1039/d4sc90232g.
Mahmoudi, Ikram, Chloé Quignot, Carla Martins, and Jessica Andreani. 2024. “Structural Comparison of Homologous Protein-RNA Interfaces Reveals Widespread Overall Conservation Contrasted with Versatility in Polar Contacts.” PLoS Computational Biology 20 (12): e1012650. https://doi.org/10.1371/journal.pcbi.1012650.
Marsin, Stéphanie, Sylvain Jeannin, Sonia Baconnais, Hélène Walbott, Gérard Pehau-Arnaudet, Magali Noiray, Magali Aumont-Nicaise, et al. 2024. “DciA, the Bacterial Replicative Helicase Loader, Promotes LLPS in the Presence of SsDNA.” Journal of Molecular Biology, November, 168873. https://doi.org/10.1016/j.jmb.2024.168873.
Ammar Khodja, Liza, Valérie Campanacci, Guy Lippens, and Benoît Gigant. 2024. “The Structure of a Tau Fragment Bound to Tubulin Prompts New Hypotheses on Tau Mechanism and Oligomerization.” PNAS Nexus 3 (11): pgae487. https://doi.org/10.1093/pnasnexus/pgae487.

Education

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