A team of virologists and immunologists dissecting the interactions between cells and viruses.
Our research focuses on viruses that lead to persistent infections in humans such as Herpesviruses and HIV-1. We study the cellular pathways used by viruses to multiply and bypass host responses; as well as the cellular compartments involved in the degradation of viral proteins/antigens and their presentation to T lymphocytes by major histocompatibility complex (MHC) molecules. We characterize the cellular mechanisms hijacked by viruses to spread and/or escape innate and adaptive immune responses. Our work will help identify new strategies for antiviral drugs and immunotherapies.
The team is made up of CNRS researchers, faculties from the University of Paris Saclay, engineers (CNRS and University), post-docs and students. We teach Virology at the Faculty of Pharmacy
Within the team, in collaboration with I2BC teams or platforms, and with other institutions in France or abroad, we use cell biology approaches in our projects (e.g. RNA silencing, CRISPR), imaging (immunofluorescence, confocal and electron microscopy), cytometry, OMIC (Ribosome profiling, protein interactome, immunopeptidome) and immunology (Elispot, ICS).
Topics
Our research program is divided into three complementary topics. Topic-1: we have a particular interest in studying autophagy, a ubiquitous degradation mechanism of the cellular components, which is hijacked by Herpesviruses in order to spread. Topic-2: we are characterizing the relationships between autophagy machinery and antiviral immunity, whether innate or adaptive. Topic-3: we are working to define the links between the translation mechanisms of viral proteins and/or polypeptides and the generation of antigens presented by MHC molecules.
The team is made up of CNRS researchers, faculties from the University of Paris Saclay, engineers (CNRS and University), post-docs and students. We teach Virology at the Faculty of Pharmacy.
ESCLATINE Audrey Group Leader Professor
MORIS Arnaud Group Leader Senior Researcher
BEAUCLAIR Guillaume Lecturer
GLON Damien Lecturer
LUSSIGNOL Marion Lecturer
GREGOIRE-FERRET Sylvie Engineer
HERNANDEZ DJEBALI Eva Engineer
LE LAY Emelyne Engineer assistant
CARDOSO MORENO Eunice PhD student
HAMOOD Alexandra PhD student
SEITE Fanette PhD student
TANTET Léa PhD student
team
The team is made up of CNRS researchers, faculties from the University of Paris Saclay, engineers (CNRS and University), post-docs and students. We teach Virology at the Faculty of Pharmacy.