Autophagy and antiviral immunity
A team of virologists and immunologists dissecting the interactions between cells and viruses.
Our research focuses on viruses that lead to persistent infections in humans such as Herpesviruses and HIV-1. We study the cellular pathways used by viruses to multiply and bypass host responses; as well as the cellular compartments involved in the degradation of viral proteins/antigens and their presentation to T lymphocytes by major histocompatibility complex (MHC) molecules. We characterize the cellular mechanisms hijacked by viruses to spread and/or escape innate and adaptive immune responses. Our work will help identify new strategies for antiviral drugs and immunotherapies.
Our team is located on the campus of the Faculty of Pharmacy of Châtenay-Malabry of the Université Paris-Saclay, but we will soon be joining the I2BC campus in Gif-sur-Yvette. The team is made up of CNRS researchers, faculties from the University of Paris Saclay, engineers (CNRS and University), post-docs and students. We teach Virology at the Faculty of Pharmacy
Within the team, in collaboration with I2BC teams or platforms, and with other institutions in France or abroad, we use cell biology approaches in our projects (e.g. RNA silencing, CRISPR), imaging (immunofluorescence, confocal and electron microscopy), cytometry, OMIC (Ribosome profiling, protein interactome, immunopeptidome) and immunology (Elispot, ICS).
Our research program is divided into three complementary topics. Topic-1: we have a particular interest in studying autophagy, a ubiquitous degradation mechanism of the cellular components, which is hijacked by Herpesviruses in order to spread. Topic-2: we are characterizing the relationships between autophagy machinery and antiviral immunity, whether innate or adaptive. Topic-3: we are working to define the links between the translation mechanisms of viral proteins and/or polypeptides and the generation of antigens presented by MHC molecules.
Our team is located on the campus of the Faculty of Pharmacy of Châtenay-Malabry of the Université Paris-Saclay, but we will soon be joining the I2BC campus in Gif-sur-Yvette.
The team is made up of CNRS researchers, faculties from the University of Paris Saclay, engineers (CNRS and University), post-docs and students. We teach Virology at the Faculty of Pharmacy.
Emelyne LE LAY
Eva HERNANDEZ DJEBALI
Former members and Alumni
Gabriela SARANGO (PhD Student)
Berta Cecilia RAMIREZ (Researcher)
Anita Kumari (Post-Doctoral researcher)
Damien Glon (PhD Student 2018-2021)
Mathilde Lumy (M2 EPHE 2020-2021)
Clemence Taisne (PhD Student 2017-2020)
Mathias Pereira (PhD Student 2016-2019)
Soledad Marsile-Medun (M2/AgroParisTech Engineer 2018-2019)
For all the publications of the Team click on the button below.