Institute for Integrative Biology of the Cell – I2BC, Institute of Integrative Biology of the Cell, is a Joint Research Unit (UMR9198) supervised by CEA, CNRS and Paris-Saclay University. I2BC is 50 Research teams, 5 departments and 15 core facilities teams.

At the Heart of the Cell:
Explore, Understand, Innovate

Biochemistry, Biophysics & Structural Biology (B3S)

Cell Biology

Genome Biology

Microbiology

Virology

Core Facilities

Welcome to the Institute for Integrative Biology of the Cell

The Institute for Integrative Biology of the Cell (I2BC) is the leading Paris-Saclay institute for molecular and cellular biology. I2BC explores how cells function as integrated systems across multiple scales, leveraging a broad spectrum of organisms and model systems.

Organized into five scientific departments, the research teams benefit from cutting-edge core facilities and a collaborative environment. Together, they drive innovative research structured around four transverse axes:

Architecture and dynamics of cellular structures and associated pathologies

Processing of genetic information and its dysfunctions

Host-microbe interactions: infectious diseases and symbiosis

Bio-inspired engineering for energy, health and the environment

Highlights

ANDREANI B3S

Oct 5th, 2026 by AMIG team from B3S Dept

New player identified in H. pylori natural transformation

Identification of a Missing Component of the Exogenous DNA Internalisation System During Natural Transformation in Helicobacter pylori.

PLOS Pathogens

LLANSOLA B3S

Oct 5th, 2026 by LEC team from B3S Dept

How the polarisability of its environment shapes the electronic excited states of lutein, a key pigment of photosynthesis

Lutein helps plants harvest sunlight and protect themselves from excess light. Ultrafast laser spectroscopy at I2BC shows that the polarisability of its environment reshapes its electronic excited states and their lifetimes.

Physical Chemistry Chemical Physics

MULLER B3S

Sept 21st, 2026 by PPP team from B3S Dept

Different Photons, Same Chemistry: Identical Mechanism and Efficiency of Fatty Acid Photodecarboxylase under Blue and UV Excitation

Blue or violet, FAP plays by the same rules: both wavelengths trigger the same photocycle with identical efficiency, intermediates, and products, overturning the proposed model of violet-enhanced activity;

ACS Catalysis

It’s happening at I2BC

FRISBI Manager Meeting (French Infrastructure for Integrated Structural Biology)

Thu 8th of October

13:00-18:00

B26-N2-000

Symposium

Linnea Maria STRANDBERG "To Split or Not to Split Water – Different Aspects of Photosystem II Activity" (eq. Krieger-Liszkay/Müller - B3S dpt)

Fri 9th of October

14:00-18:00

B26-N2-000

PhD Defense

9th FRISBI User One Day Meeting (French Infrastructure for Integrated Structural Biology)

Fri 9th of October

08:00-18:00

B21-N0-00

Symposium

Suliane QUILLERE "Caractérisation des propriétés de liaison de la protéine intrinsèquement désordonnée BRCA2 identifiée chez Physcomitrium patens" (eq. Charbonnier/Zinn-Justin - B3S dpt)

Thu 15th of October

14:00-18:00

B21-N0-00

PhD Defense

Louis Lapierre "Spatial regulation of proteostasis during aging in Caenorhabditis elegans"

Fri 16th of October

11:00-12:30

B22-N0-001

External Seminar

Club Mitochondrie

Fri 16th of October

14:00-15:00