At the Heart of the Cell:
Explore, Understand, Innovate
Welcome to the Institute for Integrative Biology of the Cell
The Institute for Integrative Biology of the Cell (I2BC) is the leading Paris-Saclay institute for molecular and cellular biology. I2BC explores how cells function as integrated systems across multiple scales, leveraging a broad spectrum of organisms and model systems.
Organized into five scientific departments, the research teams benefit from cutting-edge core facilities and a collaborative environment. Together, they drive innovative research structured around four transverse axes:
Highlights

May 13th, 2026 by Genome Biology Dept
A condensin I complex, known for shaping chromosome organization in eukaryotes, is essential to DNA elimination in Paramecium.
NAR

May 13th, 2026 by BIOCELL Dept
In Arabidopsis, RMA ion channel is a candidate for mediating cytosolic calcium signaling in response to high frequency mechanical stimulation.
New Phytologist

May 13th, 2026 by Genome Biology Dept
Master Unix for bioinformatics with a free, progressive skills sheet and interactive Sandbox.bio tutorials—no install needed!
PLOS Computational Biology

May 13th, 2026 by MicroBiology Dept
We uncovered how Agrobacterium tumefaciens exploits host carbon resources to colonize tomato, revealing quinic acid catabolism as the critical driver of its gall-specific fitness.
Environmental Microbiology

May 13th, 2026 by Genome Biology Dept
The numerous tiny germline chromosomes of Paramecia end in DNA segments produced over evolutionary time by the activity of Helitron mobile elements. These chromosome ends are eliminated during development of the individual by a novel mechanism.
BMC Biology
It’s happening at I2BC
I2BC takes part in
I2BC Key figures
600-700
people
51
research teams
17
core facilites
150
publications
per year
30
PhD defenses
per year
