Institute for Integrative Biology of the Cell

Khul Biocell

May 10th, 2022 by Cell Biology Dept

Starting the engine of the powerhouse: mitochondrial transcription and beyond

Mitochondria are the powerhouses of cells thanks to the oxidative phosphorylation system partially encoded by a small mitochondrial genome (mtDNA). Miranda et al review our current knowledge on mtDNA expression, associated disease phenotypes, and how mtDNA and nuclear gene expression are coordinated.

GIGANT - B3S

April 15th, 2022 by B3S Dept

Structural convergence between inhibitors and a regulator of microtubule dynamics

A region of CPAP, a protein regulating the length of the centrioles, is found to have a tubulin binding mode similar to that of bacterial and fungal peptide-like metabolites which inhibit cell division.

Esclatine Glon

april 15, 2022 by Virology Dept

Essential role of hyperacetylated microtubules in innate immunity escape orchestrated by the EBV-encoded BHRF1 protein

BHRF1, a multifunctional viral protein expressed during Epstein-Barr virus reactivation, modulates mitochondrial dynamics and induces MT hyperacetylation to escape innate immunity. Moreover, the loss of MT hyperacetylation impedes BHRF1 to initiate mitophagy, which is essential to inhibit the signaling pathway.

Quaranta b3S

march 18th, 2022 by B3S Dept

Insights into the photocatalytic cycle highlighted at I2BC

An iron–porphyrin bearing urea groups exhibits exceptional high performance for CO2-to-CO photocatalytic reduction.