Institute for Integrative Biology of the Cell

Deleris

October 15, 2021 by Genome Dept

Role of polycomb in the control of transposable elements
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This opinion piece reviews for the first time the evidences across kingdoms that Polycomb (PcG) Repressive Complex 2, thought to be dedicated to the epigenetic silencing of protein-coding genes, can also target, and even silence, transposable elements: could an ancestral role of PcG proteins be to silence transposable elements?

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Tissières

October 15, 2021 by Micobiology Dept

Presence of 2-hydroxymyristate on endotoxins is associated with death in
neonates with Enterobacter cloacae complex septic shock
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This is the first published evidence linking lipopolysaccharide structural moiety to neonatal sepsis outcome and opens the possibility of using the 2-hydroxymyristate marker as a detection tool for high-risk patients, which could help reduce their mortality.

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Varela

October 15, 2021 by B3S Dept

Macromolecular interactions in vitro, comparing classical and novel approaches
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In a study published in European Biophysics Journal, two teams of the B3S department (INTGEN and MIP) with the PIM platform, in collaboration with national and international experts on molecular scale biophysics compare six approches to measure macromolecular interactions in vitro. The results were obtained in the context of a Training School (ARBRE-MOBIEU COST Action) organized in 2019 in our institute.

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Auzat

October 15, 2021 by Virology Dept

Biogenesis of a gadget-free long tail bacteriophage.
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Uncovering the complete building plan and assembly pathway of a viral DNA delivery device

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Upcoming …  

External Seminar

Auditorium Bat 21, CNRS Gif-sur-Yvette*

 Oct 29th 11:00 – 13:00

vendredi 29 octobre 2021 11AM

Host cell invasion by Plasmodium sporozoites:
contribution of conventional and conditional genetic approaches

Olivier Silvie

CIMI-Paris, Sorbonne Université

Contact: Joana SANTOS <joana.santos@i2bc.paris-saclay.fr>

This seminar is part of UE “A day with the Speaker ” organized by Jean-Luc FERAT <jean-luc.ferat@i2bc.paris-saclay.fr> more informations in the Calendar

* Pass-Sanitaire is required

 External Seminar

Auditorium Bat 21, CNRS Gif-sur-Yvette *

 Nov 5th 11:00 – 13:00
vendredi 05 novembre 11AM

Erwan Gueguen

Univ. Lyon 1

Contact: Denis FAURE <denis.faure@i2bc.paris-saclay.fr> and MERGAERT Peter <peter.megaert@i2bc.paris-saclay.fr> This seminar is part of UE “A day with the Speaker ” organized by Jean-Luc FERAT <jean-luc.ferat@i2bc.paris-saclay.fr>

* Pass-Sanitaire is required

French congress on Integrative Structural Biology Paris-Saclay

 Nov 29th – Dec 3rd

The second French congress on Integrative Structural Biology (BSI), jointly organized by the Association Française de Cristallographie (AFC) and the Société Française de Bio-physique (SFB), takes place on the Paris-Saclay campus from November 29 to December 3, 2021.

Latest Publications

Le Huyen, Kim Boi, Cintia Daniela Gonzalez, Gaëtan Pascreau, Valérie Bordeau, Vincent Cattoir, Wenfeng Liu, Philippe Bouloc, Brice Felden, and Svetlana Chabelskaya. 2021. “A Small Regulatory RNA Alters Staphylococcus Aureus Virulence by Titrating RNAIII Activity.” Nucleic Acids Research, September, gkab782. https://doi.org/10.1093/nar/gkab782.
Masella, Michel, Alina Crudu, and Fabien Léonforté. 2021. “Hybrid Polarizable Simulations of a Conventional Hydrophobic Polyelectrolyte. Toward a Theoretical Tool for Green Science Innovation.” The Journal of Chemical Physics 155 (11): 114903. https://doi.org/10.1063/5.0056508.
Lefrançois, Pauline, Jérôme Santolini, and Stéphane Arbault. 2021. “Electroanalysis at a Single Giant Vesicle Generating Enzymatically a Reactive Oxygen Species.” Analytical Chemistry, September. https://doi.org/10.1021/acs.analchem.1c01208.
Ha, Kam Pou, and Andrew M. Edwards. 2021. “DNA Repair in Staphylococcus Aureus.” Microbiology and Molecular Biology Reviews: MMBR, September, e0009121. https://doi.org/10.1128/MMBR.00091-21.
Roch, Benoit, Vincent Abramowski, Olivier Etienne, Stefania Musilli, Pierre David, Jean-Baptiste Charbonnier, Isabelle Callebaut, François D. Boussin, and Jean-Pierre de Villartay. 2021. “A XRCC4 Mutant Mouse, a Model for Human X4 Syndrome, Reveals Interplays with Xlf, PAXX, and ATM in Lymphoid Development.” ELife 10 (September): e69353. https://doi.org/10.7554/eLife.69353.
Chérier, Dimitri, Delphine Patin, Didier Blanot, Thierry Touzé, and Hélène Barreteau. 2021. “The Biology of Colicin M and Its Orthologs.” Antibiotics (Basel, Switzerland) 10 (9): 1109. https://doi.org/10.3390/antibiotics10091109.
Martín-Barranco, Amanda, Sébastien Thomine, Grégory Vert, and Enric Zelazny. 2021. “A Quick Journey into the Diversity of Iron Uptake Strategies in Photosynthetic Organisms.” Plant Signaling & Behavior, September, 1975088. https://doi.org/10.1080/15592324.2021.1975088.
Rengifo-Gonzalez, Juan Carlos, Krystel El Hage, Marie-Jeanne Clément, Emilie Steiner, Vandana Joshi, Pierrick Craveur, Dominique Durand, David Pastré, and Ahmed Bouhss. 2021. “The Cooperative Binding of TDP-43 to GU-Rich RNA Repeats Antagonizes TDP-43 Aggregation.” ELife 10 (September): e67605. https://doi.org/10.7554/eLife.67605.
Fouché, Guillaume, Thomas Michel, Anaïs Lalève, Nick X. Wang, David H. Young, Brigitte Meunier, Danièle Debieu, Sabine Fillinger, and Anne-Sophie Walker. 2021. “Directed Evolution Predicts Cytochrome b G37V Target Site Modification as Probable Adaptive Mechanism towards the QiI Fungicide Fenpicoxamid in Zymoseptoria Tritici.” Environmental Microbiology, September. https://doi.org/10.1111/1462-2920.15760.
Zaworski, Julie, Oyut Dagva, Anthony W. Kingston, Alexey Fomenkov, Richard D. Morgan, Lionello Bossi, and Elisabeth A. Raleigh. 2021. “Genome Archaeology of Two Laboratory Salmonella Enterica Enterica Sv Typhimurium.” G3 (Bethesda, Md.) 11 (9): jkab226. https://doi.org/10.1093/g3journal/jkab226.
Labarre, Cécile, Nathalie Dautin, Anna Grzegorzewicz, Mary Jackson, Michael McNeil, Niloofar Mohiman, Laila Sago, and Nicolas Bayan. 2021. “S16 and T18 Mannosylation Sites of LppX Are Not Essential for Its Activity in Phthiocerol Dimycocerosates Localization at the Surface of Mycobacterium Tuberculosis.” Research in Microbiology, September, 103874. https://doi.org/10.1016/j.resmic.2021.103874.
Seul, Anait, Sandrine Brasilès, Isabelle Petitpas, Rudi Lurz, Valérie Campanacci, Christian Cambillau, Frank Weise, Mohamed Zairi, Paulo Tavares, and Isabelle Auzat. 2021. “Biogenesis of a Bacteriophage Long Non-Contractile Tail.” Journal of Molecular Biology 433 (18): 167112. https://doi.org/10.1016/j.jmb.2021.167112.
Lioy, Virginia S., Jean-Noël Lorenzi, Soumaya Najah, Thibault Poinsignon, Hervé Leh, Corinne Saulnier, Bertrand Aigle, et al. 2021. “Dynamics of the Compartmentalized Streptomyces Chromosome during Metabolic Differentiation.” Nature Communications 12 (1): 5221. https://doi.org/10.1038/s41467-021-25462-1.
Bacle, Amélie, Pavel Buslaev, Rebeca Garcia-Fandino, Fernando Favela-Rosales, Tiago Mendes Ferreira, Patrick F. J. Fuchs, Ivan Gushchin, et al. 2021. “Inverse Conformational Selection in Lipid-Protein Binding.” Journal of the American Chemical Society 143 (34): 13701–9. https://doi.org/10.1021/jacs.1c05549.
Bokor, Eszter, Michel Flipphi, Sándor Kocsubé, Judit Ámon, Csaba Vágvölgyi, Claudio Scazzocchio, and Zsuzsanna Hamari. 2021. “Genome Organization and Evolution of a Eukaryotic Nicotinate Co-Inducible Pathway.” Open Biology 11 (9): 210099. https://doi.org/10.1098/rsob.210099.
Riquier, Sébastien, Chloé Bessiere, Benoit Guibert, Anne-Laure Bouge, Anthony Boureux, Florence Ruffle, Jérôme Audoux, et al. 2021. “Kmerator Suite: Design of Specific k-Mer Signatures and Automatic Metadata Discovery in Large RNA-Seq Datasets.” NAR Genomics and Bioinformatics 3 (3): lqab058. https://doi.org/10.1093/nargab/lqab058.
Morgan, Chris, Martin A. White, F. Chris H. Franklin, Denise Zickler, Nancy Kleckner, and Kirsten Bomblies. 2021. “Evolution of Crossover Interference Enables Stable Autopolyploidy by Ensuring Pairwise Partner Connections in Arabidopsis Arenosa.” Current Biology: CB, August, S0960-9822(21)01132-5. https://doi.org/10.1016/j.cub.2021.08.028.
Nicoud, Quentin, Quentin Barrière, Nicolas Busset, Sara Dendene, Dmitrii Travin, Mickaël Bourge, Romain Le Bars, et al. 2021. “Sinorhizobium Meliloti Functions Required for Resistance to Antimicrobial NCR Peptides and Bacteroid Differentiation.” MBio 12 (4): e0089521. https://doi.org/10.1128/mBio.00895-21.
Maikova, Anna, Pierre Boudry, Anna Shiriaeva, Aleksandra Vasileva, Anaïs Boutserin, Sofia Medvedeva, Ekaterina Semenova, Konstantin Severinov, and Olga Soutourina. 2021. “Protospacer-Adjacent Motif Specificity during Clostridioides Difficile Type I-B CRISPR-Cas Interference and Adaptation.” MBio 12 (4): e0213621. https://doi.org/10.1128/mBio.02136-21.
Fekete, Erzsébet, Fruzsina Pénzes, Norbert Ág, Claudio Scazzocchio, Michel Flipphi, and Levente Karaffa. 2021. “Internally Symmetrical Stwintrons and Related Canonical Introns in Hypoxylaceae Species.” Journal of Fungi (Basel, Switzerland) 7 (9): 710. https://doi.org/10.3390/jof7090710.
Valadon, Charlène, and Olivier Namy. 2021. “The Importance of the Epi-Transcriptome in Translation Fidelity.” Non-Coding RNA 7 (3): 51. https://doi.org/10.3390/ncrna7030051.
Chaker, Ziyad, Pierre Chervy, Yves Boulard, Stéphane Bressanelli, Pascal Retailleau, Maité Paternostre, and Thibault Charpentier. 2021. “Systematic Method for the Exploration, Representation, and Classification of the Diphenylalanine Solvatomorphic Space.” The Journal of Physical Chemistry. B 125 (33): 9454–66. https://doi.org/10.1021/acs.jpcb.1c04203.
diCenzo, George C., Lisa Cangioli, Quentin Nicoud, Janis H. T. Cheng, Matthew J. Blow, Nicole Shapiro, Tanja Woyke, et al. 2021. “DNA Methylation in Ensifer Species during Free-Living Growth and during Nitrogen-Fixing Symbiosis with Medicago Spp.” https://doi.org/10.1101/2021.03.08.434416.
Rieux-Laucat, Frédéric, Jean M. Kanellopoulos, and David M. Ojcius. 2021. “Scaling the Tips of the ALPS.” Biomedical Journal, August, S2319-4170(21)00102-5. https://doi.org/10.1016/j.bj.2021.08.002.
Augusto, Luis A., Nadège Bourgeois-Nicolaos, Aude Breton, Simon Barreault, Enrique Hernandez Alonso, Stuti Gera, Véronique Faraut-Derouin, et al. 2021. “Presence of 2-Hydroxymyristate on Endotoxins Is Associated with Death in Neonates with Enterobacter Cloacae Complex Septic Shock.” IScience 24 (8): 102916. https://doi.org/10.1016/j.isci.2021.102916.
Chaplin, Amanda K., Steven W. Hardwick, Antonia Kefala Stavridi, Christopher J. Buehl, Noah J. Goff, Virginie Ropars, Shikang Liang, et al. 2021. “Cryo-EM of NHEJ Supercomplexes Provides Insights into DNA Repair.” Molecular Cell 81 (16): 3400-3409.e3. https://doi.org/10.1016/j.molcel.2021.07.005.
Marichal, Laurent, Laetitia Gargowitsch, Rafael Leite Rubim, Christina Sizun, Kalouna Kra, Stéphane Bressanelli, Yinan Dong, Sanaz Panahandeh, Roya Zandi, and Guillaume Tresset. 2021. “Relationships between RNA Topology and Nucleocapsid Structure in a Model Icosahedral Virus.” Biophysical Journal, August, S0006-3495(21)00687-1. https://doi.org/10.1016/j.bpj.2021.08.021.
Nguyen, Phong Quoc, Christine Conesa, Elise Rabut, Gabriel Bragagnolo, Célia Gouzerh, Carlos Fernández-Tornero, Pascale Lesage, Juan Reguera, and Joe L. Acker. 2021. “Ty1 Integrase Is Composed of an Active N-Terminal Domain and a Large Disordered C-Terminal Module Dispensable for Its Activity in Vitro.” The Journal of Biological Chemistry, August, 101093. https://doi.org/10.1016/j.jbc.2021.101093.
González-Alemán, Roy, Daniel Platero-Rochart, David Hernández-Castillo, Erix W. Hernández-Rodríguez, Julio Caballero, Fabrice Leclerc, and Luis Montero-Cabrera. 2021. “BitQT: A Graph-Based Approach to the Quality Threshold Clustering of Molecular Dynamics.” Bioinformatics (Oxford, England), August, btab595. https://doi.org/10.1093/bioinformatics/btab595.
Chen, Yanfang, Emmanuel Culetto, and Renaud Legouis. 2021. “A DRP-1 Dependent Autophagy Process Facilitates Rebuilding of the Mitochondrial Network and Modulates Adaptation Capacity in Response to Acute Heat Stress during C. Elegans Development.” Autophagy, August, 1–2. https://doi.org/10.1080/15548627.2021.1953821.
Ciardo, Diletta, Olivier Haccard, Hemalatha Narassimprakash, Jean-Michel Arbona, Olivier Hyrien, Benjamin Audit, Kathrin Marheineke, and Arach Goldar. 2021. “Organization of DNA Replication Origin Firing in Xenopus Egg Extracts: The Role of Intra-S Checkpoint.” Genes 12 (8): 1224. https://doi.org/10.3390/genes12081224.
Petrignani, Bianca, Samuel Rommelaere, Ketty Hakim-Mishnaevski, Florent Masson, Elodie Ramond, Reut Hilu-Dadia, Mickael Poidevin, Shu Kondo, Estee Kurant, and Bruno Lemaitre. 2021. “A Secreted Factor NimrodB4 Promotes the Elimination of Apoptotic Corpses by Phagocytes in Drosophila.” EMBO Reports, August, e52262. https://doi.org/10.15252/embr.202052262.
Merchaoui, Zied, Quitterie Laudouar, Clémence Marais, Luc Morin, Narjess Ghali, Ramy Charbel, Nada Seeman, Mostafa Mokhtari, and Pierre Tissières. 2021. “Ultrasound Guided Percutaneous Catheterization of the Brachiocephalic Vein by Small Caliber Catheter: An Alternative to Epicutaneo-Caval Catheter in Newborn and Premature Infants.” The Journal of Vascular Access, August, 11297298211034312. https://doi.org/10.1177/11297298211034311.
L’Hôte, Valentin, Régis Courbeyrette, Guillaume Pinna, Jean-Christophe Cintrat, Gwenaëlle Le Pavec, Agnès Delaunay-Moisan, Carl Mann, and Jean-Yves Thuret. 2021. “Ouabain and Chloroquine Trigger Senolysis of BRAF-V600E-Induced Senescent Cells by Targeting Autophagy.” Aging Cell, August, e13447. https://doi.org/10.1111/acel.13447.
Anchimiuk, Anna, Virginia S. Lioy, Florian Patrick Bock, Anita Minnen, Frederic Boccard, and Stephan Gruber. 2021. “A Low Smc Flux Avoids Collisions and Facilitates Chromosome Organization in Bacillus Subtilis.” ELife 10 (August): e65467. https://doi.org/10.7554/eLife.65467.
Lioy, Virginia S., Ivan Junier, and Frédéric Boccard. 2021. “Multiscale Dynamic Structuring of Bacterial Chromosomes.” Annual Review of Microbiology, August. https://doi.org/10.1146/annurev-micro-033021-113232.
Etourneaud, Laure, Angela Moussa, Emilie Rass, Diane Genet, Simon Willaume, Caroline Chabance-Okumura, Paul Wanschoor, et al. 2021. “Lamin B1 Sequesters 53BP1 to Control Its Recruitment to DNA Damage.” Science Advances 7 (35): eabb3799. https://doi.org/10.1126/sciadv.abb3799.
Ghouil, Rania, Simona Miron, Lieke Koornneef, Jasper Veerman, Maarten W. Paul, Marie-Hélène Le Du, Esther Sleddens-Linkels, et al. 2021. “BRCA2 Binding through a Cryptic Repeated Motif to HSF2BP Oligomers Does Not Impact Meiotic Recombination.” Nature Communications 12 (1): 4605. https://doi.org/10.1038/s41467-021-24871-6.
Martinat, Charlotte, Arthur Cormier, Joëlle Tobaly-Tapiero, Noé Palmic, Nicoletta Casartelli, Bijan Mahboubi, Si’Ana A. Coggins, et al. 2021. “SUMOylation of SAMHD1 at Lysine 595 Is Required for HIV-1 Restriction in Non-Cycling Cells.” Nature Communications 12 (1): 4582. https://doi.org/10.1038/s41467-021-24802-5.
Bouznif, Besma, Benoit Alunni, Mohamed Mars, Jacqui A. Shykoff, Tatiana Timchenko, and Ricardo C. Rodríguez de la Vega. 2021. “Draft Genome Sequences of Nitrogen-Fixing Bradyrhizobia Isolated from Root Nodules of Peanut, Arachis Hypogaea, Cultivated in Southern Tunisia.” Microbiology Resource Announcements 10 (29): e0043421. https://doi.org/10.1128/MRA.00434-21.
Julien, Manon, Rania Ghouil, Ambre Petitalot, Sandrine M. Caputo, Aura Carreira, and Sophie Zinn-Justin. 2021. “Intrinsic Disorder and Phosphorylation in BRCA2 Facilitate Tight Regulation of Multiple Conserved Binding Events.” Biomolecules 11 (7): 1060. https://doi.org/10.3390/biom11071060.
Sonam, Surabhi, Clémence Vigouroux, Antoine Jégou, Guillaume Romet-Lemonne, Christophe Le Clainche, Benoit Ladoux, and René Marc Mège. 2021. “Direct Measurement of Near-NanoNewton Forces Developed by Self-Organizing Actomyosin Fibres Bound α-Catenin.” Biology of the Cell, July. https://doi.org/10.1111/boc.202100014.
Marais, Clémence, Caroline Claude, Nada Semaan, Ramy Charbel, Simon Barreault, Brendan Travert, Jean-Eudes Piloquet, et al. 2021. “Myeloid Phenotypes in Severe COVID-19 Predict Secondary Infection and Mortality: A Pilot Study.” Annals of Intensive Care 11 (1): 111. https://doi.org/10.1186/s13613-021-00896-4.
Labarde, Audrey, Lina Jakutyte, Cyrille Billaudeau, Beatrix Fauler, Maria López-Sanz, Prishila Ponien, Eric Jacquet, et al. 2021. “Temporal Compartmentalization of Viral Infection in Bacterial Cells.” Proceedings of the National Academy of Sciences of the United States of America 118 (28): e2018297118. https://doi.org/10.1073/pnas.2018297118.
Ikkene, Djallal, Ana Andreea Arteni, Malika Ouldali, Gregory Francius, Annie Brûlet, Jean-Luc Six, and Khalid Ferji. 2021. “Direct Access to Polysaccharide-Based Vesicles with a Tunable Membrane Thickness in a Large Concentration Window via Polymerization-Induced Self-Assembly.” Biomacromolecules 22 (7): 3128–37. https://doi.org/10.1021/acs.biomac.1c00569.
Thomine, Sébastien, and Sylvain Merlot. 2021. “Manganese Matters: Feeding Manganese into the Secretory System for Cell Wall Synthesis.” The New Phytologist, July. https://doi.org/10.1111/nph.17545.
Hernandez, Eva, Clémence Taisne, Marion Lussignol, Audrey Esclatine, and Marc Labetoulle. 2021. “Commercially Available Eye Drops Containing Trehalose Protect Against Dry Conditions via Autophagy Induction.” Journal of Ocular Pharmacology and Therapeutics: The Official Journal of the Association for Ocular Pharmacology and Therapeutics, July. https://doi.org/10.1089/jop.2020.0119.
Postic, Guillaume, Jessica Andreani, Julien Marcoux, Victor Reys, Raphaël Guerois, Julien Rey, Emmanuelle Mouton-Barbosa, et al. 2021. “Proteo3Dnet: A Web Server for the Integration of Structural Information with Interactomics Data.” Nucleic Acids Research 49 (W1): W567–72. https://doi.org/10.1093/nar/gkab332.
Quignot, Chloé, Guillaume Postic, Hélène Bret, Julien Rey, Pierre Granger, Samuel Murail, Pablo Chacón, Jessica Andreani, Pierre Tufféry, and Raphaël Guerois. 2021. “InterEvDock3: A Combined Template-Based and Free Docking Server with Increased Performance through Explicit Modeling of Complex Homologs and Integration of Covariation-Based Contact Maps.” Nucleic Acids Research 49 (W1): W277–84. https://doi.org/10.1093/nar/gkab358.
Rollet-Cohen, Virginie, Philippe Sachs, Pierre-Louis Léger, Zied Merchaoui, Jérôme Rambaud, Laureline Berteloot, Manoëlle Kossorotoff, et al. 2021. “Transcranial Doppler Use in Non-Traumatic Critically Ill Children: A Multicentre Descriptive Study.” Frontiers in Pediatrics 9 (July): 609175. https://doi.org/10.3389/fped.2021.609175.

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