Our aim is to understand the cellular and molecular mechanisms underlying the selective elimination of cellular components by autophagy in the context of developmental processes, aging and adaptive responses to various stresses.
We contributed to demonstrate that C. elegans is a good model to analyze the autophagic processes and we have characterized the relationships between autophagosomes and endosomes. Because the autophagic pathway is highly conserved in eukaryotes, data obtained in yeast and worm are essential to understand the role of autophagy in human.