Autophagy, Stress and Development

Numerous studies have highlighted the large variety of physiological and pathophysiological roles of autophagy such as developmental process, cell death, anti-aging, antigen presentation, elimination of microorganisms and tumour suppression. The use of model organisms allows to investigate in vivo the roles and functions of autophagy.

General presentation

Our group has a general interest in intracellular trafficking and a particular focus on autophagy by using two genetic model organisms, the nematode Caenorhabditis elegans and the yeast Saccharomyces cerevisiae, that offer the possibility to analyze the autophagic process in physiological and pathological conditions.

Our aim is to understand the cellular and molecular mechanisms underlying the selective elimination of cellular components by autophagy in the context of developmental processes, aging and adaptive responses to various stresses.

We contributed to demonstrate that C. elegans is a good model to analyze the autophagic processes. Because the autophagic pathway is highly conserved in eukaryotes, data obtained in yeast and worm are essential to understand the role of autophagy in human.

We have reported the implication of autophagy in various developmental aspects and stresses, discovered that the paternal mitochondria are degraded after fertilization by a selective mitophagy process.

Yeast is particularly effective in coping with stresses such as sudden nutrient deficiencies, which allow them to survive for weeks. We discovered a specific autophagy regulation in sulfur starvation.

Topics

team

LEGOUIS Renaud
Group Leader Senior Researcher
CUIF-LORDEZ Marie-Hélène
Professor
CULETTO Emmanuel
Lecturer
KURAS Laurent
Researcher
LEFEBVRE Christophe
Lecturer
LARGEAU Celine
Engineer
PRIGENT Magali
Engineer
BLANCO BENITEZ Mercedes
PhD student
KONG Dejun
PhD student
MEIRE Valentin
PhD student
SEROT Claudia
PhD student

team

Renaud LEGOUIS

Group Leader

Research Director

Marie-Hélène
CUIF-LORDEZ

Professor

Laurent KURAS

Researcher

Emmanuel CULETTO

Assistant Professor

Celine LARGEAU

Engineer

Christophe LEFEBVRE

Assistant Professor

Alexandre POUGET

PhD student

Magali PRIGENT

Engineer

Claudia SEROT

PhD student

Publications

For all the publications of the Team click on the button below.

External Funding

(EAT ANR-12-BSV2-018)

(EAT ANR-12-BSV2-018)

(Janus 23-CE13-0013-01)

 (RoL-2018-2020)

 (AP 2021-2024)

Diagnoxi

(2019-2025)

(SFI20111203826 ; 2016-2018)

(2022-2025)

China Scholarship Council

(YC-2016-2020)

China Scholarship Council

(KD 2024-2028)

Previous members

    • Amélie ELOUIN              M2 student 
    • Romane LEBOUTET     PhD Student
    • Yanfang CHEN             PhD Student
    • Vincent SCARCELLI    PhD Student
    • Céline JENZER              PhD Student
    • Elena SIMIONATO      Post-Doc
    • Marion MANIL-SEGALEN Post-Doc
    • Guillaume SGARD  Assistant Engineer
Scroll to Top