Autophagy and Development

logo-inserm-rvb

Numerous studies have highlighted the large variety of physiological and pathophysiological roles of autophagy such as developmental process, cell death, anti-aging, antigen presentation, elimination of microorganisms and tumour suppression. The use of model organisms allows to investigate in vivo the roles and functions of autophagy.

General presentation

Our group has a general interest in intracellular trafficking and a particular focus on autophagy by using two genetic model organisms, the nematode Caenorhabditis elegans and the yeast Saccharomyces cerevisiae, that offer the possibility to analyze the autophagic process in physiological and pathological conditions.

Our aim is to understand the cellular and molecular mechanisms underlying the selective elimination of cellular components by autophagy in the context of developmental processes, aging and adaptive responses to various stresses.

We contributed to demonstrate that C. elegans is a good model to analyze the autophagic processes and we have characterized the relationships between autophagosomes and endosomes. Because the autophagic pathway is highly conserved in eukaryotes, data obtained in yeast and worm are essential to understand the role of autophagy in human.

We have reported the implication of autophagy in various developmental aspects and discovered that the paternal mitochondria are degraded after fertilization by a selective mitophagy process.

Topics

team

Renaud LEGOUIS

Group Leader

Research Director

Marie-Hélène
CUIF-LORDEZ

Professor

Emmanuel CULETTO

Assistant Professor

Amélie ELOUIN

M2 student

Celine LARGEAU

Engineer

Romane LEBOUTET

PhD student

Christophe LEFEBVRE

Assistant Professor

Alexandre POUGET

PhD student

Magali PRIGENT

Engineer

Publications

For all the publications of the Team click on the button below.

External Funding

China Scholarship Council

(YC-2016-2020)

 (RoL-2018-2020)

(EAT; ANR-12-BSV2-018)

(SFI20111203826 ; 2016-2018)

 (VS -2017-2019 ; M29506 ; 2018-2020)

Previous members

Yanfang CHEN 

 PhD Student

Vincent SCARCELLI 

 PhD Student

Céline JENZER

PhD Student

Elena SIMIONATO 

Post-Doc

Marion MANIL-SEGALEN

Post-Doc

Guillaume SGARD  

Assistant Enginee

logo-inserm-rvb
Scroll to Top