Autophagy, Stress and Development
Numerous studies have highlighted the large variety of physiological and pathophysiological roles of autophagy such as developmental process, cell death, anti-aging, antigen presentation, elimination of microorganisms and tumour suppression. The use of model organisms allows to investigate in vivo the roles and functions of autophagy.
General presentation
Our group has a general interest in intracellular trafficking and a particular focus on autophagy by using two genetic model organisms, the nematode Caenorhabditis elegans and the yeast Saccharomyces cerevisiae, that offer the possibility to analyze the autophagic process in physiological and pathological conditions.
Our aim is to understand the cellular and molecular mechanisms underlying the selective elimination of cellular components by autophagy in the context of developmental processes, aging and adaptive responses to various stresses.
We contributed to demonstrate that C. elegans is a good model to analyze the autophagic processes. Because the autophagic pathway is highly conserved in eukaryotes, data obtained in yeast and worm are essential to understand the role of autophagy in human.
We have reported the implication of autophagy in various developmental aspects and stresses, discovered that the paternal mitochondria are degraded after fertilization by a selective mitophagy process.
Yeast is particularly effective in coping with stresses such as sudden nutrient deficiencies, which allow them to survive for weeks. We discovered a specific autophagy regulation in sulfur starvation.
Topics
team
Group Leader Senior Researcher
Professor
Lecturer
Researcher
Lecturer
Engineer
Engineer
PhD student
PhD student
PhD student
team
Renaud LEGOUIS
Group Leader
Research Director
Marie-Hélène
CUIF-LORDEZ
Professor
Laurent KURAS
Researcher
Emmanuel CULETTO
Assistant Professor
Celine LARGEAU
Engineer
Christophe LEFEBVRE
Assistant Professor
Alexandre POUGET
PhD student
Magali PRIGENT
Engineer
Claudia SEROT
PhD student
External Funding
(EAT ANR-12-BSV2-018)
(EAT ANR-12-BSV2-018)
(Janus 23-CE13-0013-01)
(RoL-2018-2020)
(AP 2021-2024)
Diagnoxi
(2019-2025)
(SFI20111203826 ; 2016-2018)
(2022-2025)
China Scholarship Council
(YC-2016-2020)
China Scholarship Council
(KD 2024-2028)
Previous members
- Amélie ELOUIN M2 student
- Romane LEBOUTET PhD Student
- Yanfang CHEN PhD Student
- Vincent SCARCELLI PhD Student
- Céline JENZER PhD Student
- Elena SIMIONATO Post-Doc
- Marion MANIL-SEGALEN Post-Doc
- Guillaume SGARD Assistant Engineer