Biochemistry of Metalloproteins
and Associated Diseases


Dijk, Erwin L. van, Delphine Naquin, Kévin Gorrichon, Yan Jaszczyszyn, Rania Ouazahrou, Claude Thermes, and Céline Hernandez. 2023. “Genomics in the Long-Read Sequencing Era.” Trends in Genetics: TIG, May, S0168-9525(23)00119-1.
Figueroa-Bossi, Nara, Roberto Balbontín, and Lionello Bossi. 2023. “Mapping Transposon Insertion Sites by Inverse Polymerase Chain Reaction and Sanger Sequencing.” Cold Spring Harbor Protocols, May.
Figueroa-Bossi, Nara, Roberto Balbontín, and Lionello Bossi. 2023. “Use of Transposable Reporters in the Analysis of Bacterial Regulatory Networks.” Cold Spring Harbor Protocols, May.
Figueroa-Bossi, Nara, Roberto Balbontín, and Lionello Bossi. 2023. “Generating Libraries of Random LacZY or GFP Gene Fusions in the Bacterial Chromosome: Screening for Differentially Expressed Fusions.” Cold Spring Harbor Protocols, May.
Feng, Shi Yuan, Yolande Hauck, Fedy Morgene, Roza Mohammedi, and Nicolas Mirouze. 2023. “The Complex Regulation of Competence in Staphylococcus Aureus under Microaerobic Conditions.” Communications Biology 6 (1): 512.
Gout, Jean-Francois, Yue Hao, Parul Johri, Olivier Arnaiz, Thomas G. Doak, Simran Bhullar, Arnaud Couloux, et al. 2023. “Dynamics of Gene Loss Following Ancient Whole-Genome Duplication in the Cryptic Paramecium Complex.” Molecular Biology and Evolution, May, msad107.
Chen, X., K. Avia, A. Forler, C. Remoué, A. Venon, A. Rousselet, G. Lucas, et al. 2023. “Ecological and Evolutionary Drivers of Phenotypic and Genetic Variation in the European Crabapple (Malus Sylvestris (L.) Mill.), a Wild Relative of the Cultivated Apple.” Annals of Botany, May, mcad061.
Girard, Chloe, David Zwicker, and Raphael Mercier. 2023. “The Regulation of Meiotic Crossover Distribution: A Coarse Solution to a Century-Old Mystery?” Biochemical Society Transactions, May, BST20221329.
Clerissi, Camille, Xing Luo, Aude Lucasson, Shogofa Mortaza, Julien de Lorgeril, Eve Toulza, Bruno Petton, et al. 2023. “A Core of Functional Complementary Bacteria Infects Oysters in Pacific Oyster Mortality Syndrome.” Animal Microbiome 5 (1): 26.
André, Kévin M., Nathalie Giordanengo Aiach, Veronica Martinez-Fernandez, Leo Zeitler, Adriana Alberti, Arach Goldar, Michel Werner, Cyril Denby Wilkes, and Julie Soutourina. 2023. “Functional Interplay between Mediator and RSC Chromatin Remodeling Complex Controls Nucleosome-Depleted Region Maintenance at Promoters.” Cell Reports 42 (5): 112465.
Brual, Typhaine, Géraldine Effantin, Julie Baltenneck, Laetitia Attaiech, Cloé Grosbois, Monique Royer, Jérémy Cigna, Denis Faure, Nicole Hugouvieux-Cotte-Pattat, and Erwan Gueguen. 2023. “A Natural Single Nucleotide Mutation in the Small Regulatory RNA ArcZ of Dickeya Solani Switches off the Antimicrobial Activities against Yeast and Bacteria.” PLoS Genetics 19 (4): e1010725.
Gaïa, Morgan, Lingjie Meng, Eric Pelletier, Patrick Forterre, Chiara Vanni, Antonio Fernandez-Guerra, Olivier Jaillon, et al. 2023. “Mirusviruses Link Herpesviruses to Giant Viruses.” Nature, April.
Boussac, Alain, Julien Sellés, and Miwa Sugiura. 2023. “Energetics and Proton Release in Photosystem II from Thermosynechococcus Elongatus with a D1 Protein Encoded by Either the PsbA2 or PsbA3 Gene.” Biochimica Et Biophysica Acta. Bioenergetics 1864 (3): 148979.
Valencia-Gallardo, Cesar, Daniel-Isui Aguilar-Salvador, Hamed Khakzad, Benjamin Cocom-Chan, Charles Bou-Nader, Christophe Velours, Yosra Zarrouk, et al. 2023. “Shigella IpaA Mediates Actin Bundling through Diffusible Vinculin Oligomers with Activation Imprint.” Cell Reports 42 (4): 112405.
Pernier, Julien, Marcelina Cardoso Dos Santos, Mariem Souissi, Adrien Joly, Hemalatha Narassimprakash, Olivier Rossier, Grégory Giannone, Emmanuèle Helfer, Kheya Sengupta, and Christophe Le Clainche. 2023. “Talin and Kindlin Cooperate to Control the Density of Integrin Clusters.” Journal of Cell Science 136 (8): jcs260746.
Brison, Olivier, Stefano Gnan, Dana Azar, Stéphane Koundrioukoff, Rodrigo Melendez-Garcia, Su-Jung Kim, Mélanie Schmidt, et al. 2023. “Mistimed Origin Licensing and Activation Stabilize Common Fragile Sites under Tight DNA-Replication Checkpoint Activation.” Nature Structural & Molecular Biology, April.
Samire, Poutoum P., Bo Zhuang, Bertrand Légeret, Ángel Baca-Porcel, Gilles Peltier, Damien Sorigué, Alexey Aleksandrov, Frédéric Beisson, and Pavel Müller. 2023. “Autocatalytic Effect Boosts the Production of Medium-Chain Hydrocarbons by Fatty Acid Photodecarboxylase.” Science Advances 9 (13): eadg3881.
Tabares, Leandro C., Davis T. Daniel, José Luis Vázquez-Ibar, Cyrille Kouklovsky, Valérie Alezra, and Sun Un. 2023. “Using the Noncanonical Metallo-Amino Acid [Cu(II)(2,2’-Bipyridin-5-Yl)]-Alanine to Study the Structures of Proteins.” The Journal of Physical Chemistry Letters, March, 3368–75.
Arnesen, Thomas, Henriette Aksnes, and Carmela Giglione. 2023. “Protein Termini 2022: Central Roles of Protein Ends.” Trends in Biochemical Sciences, March, S0968-0004(23)00075-0.
Nguyen, Phong Quoc, Sonia Huecas, Amna Asif-Laidin, Adrián Plaza-Pegueroles, Beatrice Capuzzi, Noé Palmic, Christine Conesa, et al. 2023. “Structural Basis of Ty1 Integrase Tethering to RNA Polymerase III for Targeted Retrotransposon Integration.” Nature Communications 14 (1): 1729.
Schvartz, Marion, Florent Saudrais, Stéphanie Devineau, Stéphane Chédin, Frédéric Jamme, Jocelyne Leroy, Karol Rakotozandriny, et al. 2023. “Role of the Protein Corona in the Colloidal Behavior of Microplastics.” Langmuir: The ACS Journal of Surfaces and Colloids, March.
Abd Al-Razaq, Mutaz A., Benjamin M. Freyter, Anna Isermann, Gargi Tewary, Adèle Mangelinck, Carl Mann, and Claudia E. Rübe. 2023. “Role of Histone Variant H2A.J in Fine-Tuning Chromatin Organization for the Establishment of Ionizing Radiation-Induced Senescence.” Cells 12 (6): 916.
Misuan, Nurhamimah, Saharuddin Mohamad, Thibault Tubiana, and Michelle Khai Khun Yap. 2023. “Ensemble-Based Molecular Docking and Spectrofluorometric Analysis of Interaction between Cytotoxin and Tumor Necrosis Factor Receptor 1.” Journal of Biomolecular Structure & Dynamics, March, 1–15.
Moreaud, Laureen, Sébastien Viollet, Agathe Urvoas, Marie Valerio-Lepiniec, Agnès Mesneau, Inès Li de la Sierra-Gallay, Jessalyn Miller, et al. 2023. “Design, Synthesis, and Characterization of Protein Origami Based on Self-Assembly of a Brick and Staple Artificial Protein Pair.” Proceedings of the National Academy of Sciences of the United States of America 120 (11): e2218428120.
Roux, Michel, François-Xavier Legrand, Abed Bil, Véronique Bonnet, and Florence Djedaini-Pilard. 2023. “Fragmentation of DMPC Membranes by a Wedge-Shaped Amphiphilic Cyclodextrin into Bicellar-like Aggregates.” The Journal of Physical Chemistry. B, March.
Marcelot, Agathe, Felipe Rodriguez-Tirado, Philippe Cuniasse, Mei-Ling Joiner, Simona Miron, Alexey A. Soshnev, Mimi Fang, et al. 2023. “A De Novo Sequence Variant in Barrier-to-Autointegration Factor Is Associated with Dominant Motor Neuronopathy.” Cells 12 (6): 847.
Mezzetti, Alberto, Jean-François Paul, and Winfried Leibl. 2023. “Identification of a Ubiquinone-Ubiquinol Quinhydrone Complex in Bacterial Photosynthetic Membranes and Isolated Reaction Centers by Time-Resolved Infrared Spectroscopy.” International Journal of Molecular Sciences 24 (6): 5233.
Pavao, Aidan, Brintha Girinathan, Johann Peltier, Pamela Altamirano Silva, Bruno Dupuy, Isabella H. Muti, Craig Malloy, Leo L. Cheng, and Lynn Bry. 2023. “Elucidating Dynamic Anaerobe Metabolism with HRMAS 13C NMR and Genome-Scale Modeling.” Nature Chemical Biology, March.
C, Chenebault, Blanc-Garin V, Vincent M, Diaz-Santos E, Goudet A, Cassier-Chauvat C, and Chauvat F. 2023. “Exploring the Potential of the Model Cyanobacteria Synechococcus PCC 7002 and PCC 7942 for the Photoproduction of High-Value Terpenes: A Comparison with Synechocystis PCC 6803.” Biomolecules 13 (3).
Sassano, Maria Livia, Alexander R. van Vliet, Ellen Vervoort, Sofie Van Eygen, Chris Van den Haute, Benjamin Pavie, Joris Roels, et al. 2023. “PERK Recruits E-Syt1 at ER-Mitochondria Contacts for Mitochondrial Lipid Transport and Respiration.” The Journal of Cell Biology 222 (3): e202206008.
Chen, Hong, Timur Borjigin, Christophe Regeard, Pu Xiao, Frédéric Dumur, and Jacques Lalevée. 2023. “5,12-Dihydroindolo[3,2-a]Carbazole Derivatives-Based Water Soluble Photoinitiators for 3D Antibacterial Hydrogels Preparation.” Small (Weinheim an Der Bergstrasse, Germany), March, e2300772.
Leccese, Silvia, Adjélé Wilson, Diana Kirilovsky, Riccardo Spezia, Claude Jolivalt, and Alberto Mezzetti. 2023. “Light-Induced Infrared Difference Spectroscopy on Three Different Forms of Orange Carotenoid Protein: Focus on Carotenoid Vibrations.” Photochemical & Photobiological Sciences: Official Journal of the European Photochemistry Association and the European Society for Photobiology, February.
Audoynaud, Charlotte, Kamila Schirmeisen, Anissia Ait Saada, Armelle Gesnik, Paloma Fernández-Varela, Virginie Boucherit, Virginie Ropars, et al. 2023. “RNA:DNA Hybrids from Okazaki Fragments Contribute to Establish the Ku-Mediated Barrier to Replication-Fork Degradation.” Molecular Cell, February, S1097-2765(23)00106-5.
Figueroa-Bossi, Nara, Roberto Balbontín, and Lionello Bossi. 2023. “Scarless DNA Recombineering.” Cold Spring Harbor Protocols, February.
Figueroa-Bossi, Nara, Roberto Balbontín, and Lionello Bossi. 2023. “Recombineering 101: Making an in-Frame Deletion Mutant.” Cold Spring Harbor Protocols, February.
Figueroa-Bossi, Nara, Roberto Balbontín, and Lionello Bossi. 2023. “DNA Recombineering Applications.” Cold Spring Harbor Protocols, February.
Balbontín, Roberto, Mathilde Ratel, Nara Figueroa-Bossi, and Lionello Bossi. 2023. “Converting an FRT-Tagged Gene into a Fluorescent Protein Gene Fusion by Flp-Mediated Site-Specific Recombination.” Cold Spring Harbor Protocols, February.
Balbontín, Roberto, Nara Figueroa-Bossi, and Lionello Bossi. 2023. “Construction of Single-Copy Fluorescent Protein Fusions by One-Step Recombineering.” Cold Spring Harbor Protocols, February.
Travin, Dmitrii Y., Romain Jouan, Armelle Vigouroux, Satomi Inaba-Inoue, Joy Lachat, Fazal Haq, Tatiana Timchenko, et al. 2023. “Dual-Uptake Mode of the Antibiotic Phazolicin Prevents Resistance Acquisition by Gram-Negative Bacteria.” MBio, February, e0021723.
Royer, Alexia L. M., Andrew A. Umansky, Marie-Maude Allen, Julian R. Garneau, Maicol Ospina-Bedoya, Joseph A. Kirk, Gregory Govoni, Robert P. Fagan, Olga Soutourina, and Louis-Charles Fortier. 2023. “Clostridioides Difficile S-Layer Protein A (SlpA) Serves as a General Phage Receptor.” Microbiology Spectrum, February, e0389422.
Bělíček, Jakub, Eva Ľuptáková, David Kopečný, Jan Frömmel, Armelle Vigouroux, Sanja Ćavar Zeljković, Franjo Jagic, et al. 2023. “Biochemical Ans Structural Basis of Polyamine, Lysine and Ornithine Acetylation Catalyzed by Spermine/Spermidine N-Acetyl Transferase in Moss and Maize.” The Plant Journal: For Cell and Molecular Biology, February.
Charvin, Magali, Thierry Halter, Romain Blanc-Mathieu, Pierre Barraud, Magali Aumont-Nicaise, François Parcy, and Lionel Navarro. 2023. “Single-Cytosine Methylation at W-Boxes Repels Binding of WRKY Transcription Factors through Steric Hindrance.” Plant Physiology, February, kiad069.
Osman, J. R., G. R. Fernandes, E. Kamilova, and M. S. DuBow. 2023. “Genomic Microbiome Analyses of Surface Sand Samples from the Kyzyl-Kum Desert (Uzbekistan): Characterization and Comparative Study.” Archives of Microbiology 205 (3): 90.
Shen, Minjia, Kelly Goldlust, Sandra Daniel, Christian Lesterlin, and Yoshiharu Yamaichi. 2023. “Recipient UvrD Helicase Is Involved in Single- to Double-Stranded DNA Conversion during Conjugative Plasmid Transfer.” Nucleic Acids Research, February, gkad075.
Leger, Corentin, Irène Pitard, Mirko Sadi, Nicolas Carvalho, Sébastien Brier, Ariel Mechaly, Sylviane Hoos, et al. 2023. “Dynamics and Structural Changes of Calmodulin upon Interaction with the Antagonist Calmidazolium.” Biophysical Journal 122 (3S1): 41a.
Vittorelli, Nina, Ricardo C. Rodríguez de la Vega, Alodie Snirc, Emilie Levert, Valérie Gautier, Christophe Lalanne, Elsa De Filippo, et al. 2023. “Stepwise Recombination Suppression around the Mating-Type Locus in an Ascomycete Fungus with Self-Fertile Spores.” PLoS Genetics 19 (2): e1010347.
Pontisso, Ilaria, Roberto Ornelas Guevara, Laurent Combettes, and Geneviève Dupont. 2023. “A Journey in UPR Modeling.” Biology of the Cell, February.
Lignieres, Laurent, Nicolas Sénécaut, Tien Dang, Laura Bellutti, Marion Hamon, Samuel Terrier, Véronique Legros, et al. 2023. “Extending the Range of SLIM-Labeling Applications: From Human Cell Lines in Culture to Caenorhabditis Elegans Whole-Organism Labeling.” Journal of Proteome Research, February.
Ceppi, Ilaria, Elda Cannavo, Hélène Bret, Rosa Camarillo, Francesca Vivalda, Roshan Singh Thakur, Amador Romero-Franco, et al. 2023. “PLK1 Regulates CtIP and DNA2 Interplay in Long-Range DNA End Resection.” Genes & Development, February.
Hao, Yanning, Hong Jiang, Pratik Thapa, Na Ding, Aziza Alshahrani, Junichi Fujii, Michel B. Toledano, and Qiou Wei. 2023. “Critical Role of the Sulfiredoxin-Peroxiredoxin IV Axis in Urethane-Induced Non-Small Cell Lung Cancer.” Antioxidants (Basel, Switzerland) 12 (2): 367.


  • Srour B., Gervason S., Want K., Monfort B., Sizun C., Schunemann V., Fonda E., Dutkiewicz R., Goldberg P., Guigliarelli B., Burlat B., D’Autréaux B.* Iron insertion at the assembly site of the ISCU scaffold protein is a conserved process initiating Fe-S cluster biosynthesis J. Am. Chem. Soc. (2022), 144(38), 17496-17515
  • Monfort B., Want K., Gervason S., D’Autréaux B.* Recent advances in the elucidation of Frataxin biochemical function open novel perspectives for the treatment of Friedreich’s ataxia Front. Neurosci. (2022), 16, 1-17


  • Gervason S., Srour B., D’Autréaux B.* A Fast and Ratiometric Method for Quantification of Cysteine-Bound Persulfides Based on Alkylation Gel-Shift Assays Methods Mol. Biol. (2021), 2353, 191-205
  • Maková B., Mik V., Lišková B., D’Autréaux B., Hajdúch M., Strnad M., Voller J. Cytoprotective activities of kinetin purine isosteres Bioorg. Med. Chem. (2021), 33, 115993


  • Gervason S., Srour B., D’Autréaux B.* Mechanism of iron-sulfur cluster assembly: in the intimacy of iron and sulfur encounter Inorganics Review (2020), 8(10), 55-93
  • Russi M., Martin E., D’Autréaux B., Tixier L., Tricoire H., Monnier V. A Drosophila model of Friedreich Ataxia with CRISPR/Cas9 insertion of GAA repeats in the frataxin gene reveals in vivo protection by N-Acetyl Cysteine Hum. Mol. Genet. (2020), 29(17), 2831-2844


  • Gervason S., Grandas A., Fontecave M., Schünemann V., Cianférani S., Sizun C., Tolédano M.B., D’Autréaux B.* Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin Nature Commun. (2019), 10(1):3566.


  • Ponsero A., Igbaria A., Darch M., Miled S., Outten C.E., Winther J.R., Palais G., D’Autreaux B., Delaunay-Moisan A., Toledano M.B. Endoplasmic Reticulum Transport of Glutathione by Sec61 Is Regulated by Ero1 and Bip Molecular Cell, (2017), 67(6):962-973.
  • Bersweiler A., D’Autréaux B., Mazon H., Kriznik A., Belli G., Delaunay-Moisan A., Toledano M.B., Rahuel-Clermont S. A scaffold protein that chaperones a cysteine-sulfenic acid in H2O2 signaling Nature Chem. Biol. (2017), 13(8):909-915.


  • Parent A., Elduque X., Cornu D., Belot L., Le Caer J.P., Grandas A., Toledano M., D’Autréaux B.* Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to bo ISCU and free thiols Nature Commun. (2015), 6:5686
  • Noichri Y., Palais G., Ruby V., D’autreaux B., Delaunay-Moisan A., Nyström T., Toledano M. In vivo parameters influencing 2-Cys Prx oligomerization: The role of enzyme sulfinylation Redox biology (2015) 6, 326-333

Prior to 2015

  • Martin D., Charpilienne A., Parent A., Boussac A., D’Autréaux B., Poupon J., Poncet D. The rotavirus nonstructural protein NSP5 coordinates a [2Fe-2S] iron-sulfur cluster that modulates interaction to RNA FASEB J. (2013), 27(3):1074-83
  • Spiro S., D’Autréaux B.* Non-Heme Iron Sensors of Reactive Oxygen and Nitrogen Species Antioxid. Redox Signal., (2012), 17(9):1264-1276
  • Kumar C., Igbaria A., D’Autréaux B., Planson A.G., Junot C., Godat E., Bachhawat A.K., Delaunay-Moisan A., Toledano M.B. Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol-redox control EMBO J. (2011), 30(10):2044-56.
  • Soler N., Delagoutte E., Miron S., Facca C., Baïlle D., D’Autreaux B., Craescu G., Frapart Y., Mansuy D., Baldacci G., Huang M., Vernis L. Interaction between the reductase Tah18 and highly conserved Fe‐S containing Dre2 C‐terminus is essential for yeast viability Mol. Microbiol. (2011), 82 (1), 54-67
  • Toledano M.B. , Fourquet S., D’Autréaux B. Cellular signaling by reactive oxygen species: biochemical basis and physiological scope, Signal Transduction: Pathways, Mechanisms and Diseases, (2010), 1, 313-336
  • Kumar C., Igbaria A., D’Autreaux B., Toledano M.B. The cellular functions of eukaryotic GSH and thioredoxin pathways revisited, FEBS J. (2009), 276, 43
  • Fourquet S., Huang M.E., D’Autreaux B., Toledano M.B. The Dual Functions of Thiol-Based Peroxidases in H2O2 Scavenging and Signaling Antioxid. Redox Signal. (2009), 10 (9), 1565-1576
  • Tucker N.P.†, D’Autréaux B.†, Yousafzai F., Fairhurst S., Spiro S., Dixon R. Analysis of the nitric oxide-sensing non-heme iron center in the NorR regulatory protein J. Biol. Chem. (2008), 283(2):908-918.
  • D’Autréaux B., Tucker N., Spiro S., Dixon R. Characterization of the nitric oxide-reactive transcriptional activator NorR Methods Enzymol. (2008) 437, 235-251
  • Guerrier L., D’Autreaux B., Atanassov C., Khoder G., Boschetti E. Evaluation of a standardized method of protein purification and identification after discovery by mass spectrometry J. Proteomics (2008) 71 (3), 368-378
  • D’Autréaux B., Toledano M.B. ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis Nature Rev. Mol. Cell. Biol. (2007), 8(10):813-24.
  • D’Autréaux B., Pecqueur L., Gonzalez de Peredo A., Diederix R.E., Tabet L., Bersch B., Forest E., Michaud-Soret I. Reversible redox- and zinc-dependent dimerization of the Escherichia coli fur protein Biochemistry (2007), 46(5):1329-1342.
  • Pecqueur L.†, D’Autréaux B.†, Dupuy J., Nicolet Y., Jacquamet L., Brutscher B., Michaud-Soret I., Bersch B. Structural changes of Escherichia coli ferric uptake regulator during metal-dependent dimerization and activation explored by NMR and X-ray crystallography J. Biol. Chem. (2006), 281(30):21286-95.
  • D’Autréaux B., Tucker N.P., Dixon R., Spiro S. A non-haem iron centre in the transcription factor NorR senses nitric oxide Nature (2005), 437(7059):769-772.
  • Tucker N., D’autreaux B., Studholme D., Spiro S., Dixon R. DNA Binding Activity of the Escherichia coli Nitric Oxide Sensor NorR Suggests a Conserved Target Sequence in Diverse Proteobacteria J. Bacteriol. (2004) 186 (19), 6656-6660
  • D’Autréaux B., Horner O., Gambarelli S., Berthomieu C., Latour J.M., Michaud-Soret I. Spectroscopic description of the two nitrosyl-iron complexes responsible for fur inhibition by nitric oxide J. Am. Chem. Soc. (2004); 126(19):6005-16.
  • D’Autréaux B., Touati D., Bersch B., Latour J.M., Michaud-Soret I. Direct inhibition by nitric oxide of the transcriptional ferric uptake regulation protein via nitrosylation of the iron Proc. Natl. Acad. Sci. USA (2002); 99(26):16619-24.
Scroll to Top