Autophagy and antiviral immunity

Publications

Bertrand, Lisa, Annika Nelde, Bertha Cecilia Ramirez, Isabelle Hatin, Hugo Arbes, Pauline François, Stéphane Demais, et al. 2025. “Unveiling Conserved HIV-1 Open Reading Frames Encoding T Cell Antigens Using Ribosome Profiling.” Nature Communications 16 (1): 1707. https://doi.org/10.1038/s41467-025-56773-2.
Bertrand, Lisa, Annika Nelde, Bertha Cecilia Ramirez, Isabelle Hatin, Hugo Arbes, Pauline François, Stéphane Demais, et al. 2025. “Author Correction: Unveiling Conserved HIV-1 Open Reading Frames Encoding T Cell Antigens Using Ribosome Profiling.” Nature Communications 16 (1): 2243. https://doi.org/10.1038/s41467-025-57621-z.
Labaronne, Emmanuel, Didier Décimo, Lisa Bertrand, Laura Guiguettaz, Thibault J. M. Sohier, David Cluet, Valérie Vivet-Boudou, et al. 2025. “Non-AUG HIV-1 UORF Translation Elicits Specific T Cell Immune Response and Regulates Viral Transcript Expression.” Nature Communications 16 (1): 1706. https://doi.org/10.1038/s41467-025-56772-3.
Münz, Christian, Grant R. Campbell, Audrey Esclatine, Mathias Faure, Patrick Labonte, Marion Lussignol, Anthony Orvedahl, et al. 2025. “Autophagy Machinery as Exploited by Viruses.” Autophagy Reports 4 (1): 27694127.2025.2464986. https://doi.org/10.1080/27694127.2025.2464986.
Bhargava, Anvita, Ugo Szachnowski, Maxime Chazal, Dominika Foretek, Vincent Caval, Sophie-Marie Aicher, Juliana Pipoli da Fonseca, et al. 2023. “Transcriptomic Analysis of Sorted Lung Cells Revealed a Proviral Activity of the NF-ΚB Pathway toward SARS-CoV-2.” IScience 26 (12): 108449. https://doi.org/10.1016/j.isci.2023.108449.
Wu, Yu, Clémence Taisne, Nassim Mahtal, Alison Forrester, Marion Lussignol, Jean-Christophe Cintrat, Audrey Esclatine, Daniel Gillet, and Julien Barbier. 2023. “Autophagic Degradation Is Involved in Cell Protection against Ricin Toxin.” Toxins 15 (5): 304. https://doi.org/10.3390/toxins15050304.
Glon, Damien, Géraldine Vilmen, Daniel Perdiz, Eva Hernandez, Guillaume Beauclair, Frédérique Quignon, Clarisse Berlioz-Torrent, et al. 2022. “Essential Role of Hyperacetylated Microtubules in Innate Immunity Escape Orchestrated by the EBV-Encoded BHRF1 Protein.” PLOS Pathogens 18 (3): e1010371. https://doi.org/10.1371/journal.ppat.1010371.
Jeger-Madiot, Raphaël, Romain Vaineau, Maud Heredia, Nicolas Tchitchek, Lisa Bertrand, Mathias Pereira, Océane Konza, et al. 2022. “Naive and Memory CD4+ T Cell Subsets Can Contribute to the Generation of Human Tfh Cells.” IScience 25 (1). https://doi.org/10.1016/j.isci.2021.103566.
Lapaquette, Pierre, Amandine Ducreux, Louise Basmaciyan, Tracy Paradis, Fabienne Bon, Amandine Bataille, Pascale Winckler, et al. 2022. “Membrane Protective Role of Autophagic Machinery during Infection of Epithelial Cells by Candida Albicans.” Gut Microbes 14 (1): 2004798. https://doi.org/10.1080/19490976.2021.2004798.
Sarango, Gabriela, Clémence Richetta, Mathias Pereira, Anita Kumari, Michael Ghosh, Lisa Bertrand, Cédric Pionneau, et al. 2022. “The Autophagy Receptor TAX1BP1 (T6BP) Improves Antigen Presentation by MHC-II Molecules.” EMBO Reports n/a (n/a): e55470. https://doi.org/10.15252/embr.202255470.
Bakoa, Florian, Christophe Préhaud, Guillaume Beauclair, Maxime Chazal, Nathalie Mantel, Monique Lafon, and Nolwenn Jouvenet. 2021. “Genomic Diversity Contributes to the Neuroinvasiveness of the Yellow Fever French Neurotropic Vaccine.” NPJ Vaccines 6 (1): 64. https://doi.org/10.1038/s41541-021-00318-3.
Hernandez, Eva, Clémence Taisne, Marion Lussignol, Audrey Esclatine, and Marc Labetoulle. 2021. “Commercially Available Eye Drops Containing Trehalose Protect Against Dry Conditions via Autophagy Induction.” Journal of Ocular Pharmacology and Therapeutics: The Official Journal of the Association for Ocular Pharmacology and Therapeutics, July. https://doi.org/10.1089/jop.2020.0119.
Mori, Luisa, Katharine Jenike, Yang-Hui Jimmy Yeh, Benoît Lacombe, Chuan Li, Adam J. Getzler, Sonia Mediouni, et al. 2021. “The XPB Subunit of the TFIIH Complex Plays a Critical Role in HIV-1 Transcription, and XPB Inhibition by Spironolactone Prevents HIV-1 Reactivation from Latency.” Journal of Virology 95 (4). https://doi.org/10.1128/JVI.01247-20.

2020

 Glon D, Lussignol M and Esclatine A (2020). La mitophagie : une stratégie du virus d’Epstein-Barr pour échapper à l’immunité innée. Médecine/Sciences 36 (11): 990–93.
https://doi.org/10.1051/medsci/2020185.

 López Giuliani AC, Hernández E, Tohmé MJ, Taisne C, Roldán JS, García Samartino C, Lussignol M, Codogno P, María I. Colombo MI, Esclatine A* and Delgui LR* (2020). Human Cytomegalovirus Inhibits Autophagy of Renal Tubular Epithelial Cells and Promotes Cellular Enlargement. Frontiers in Cellular and Infection Microbiology 10: 474.
https://doi.org/10.3389/fcimb.2020.00474.

 Martella C, Tollenaere A.I, Waast L, Lacombe B, Groussaud D, Margottin-Goguet F, Ramírez BC and Pique C (2020). Human T-cell lymphotropic virus type 1 transactivator Tax exploits the XPB subunit of TFIIH during viral transcription. Journal of Virology 94:e02171-19.
https://doi.org/10.1128/JVI.02171-19.

 Vilmen G, Glon D, Siracusano G, Lussignol M, Shao Z, Hernández E, Perdiz D, Quignon F, Mouna L, Poüs C, Gruffat H, Maréchal V and Esclatine A (2020). BHRF1, a BCL2 Viral Homolog, Disturbs Mitochondrial Dynamics and Stimulates Mitophagy to Dampen Type I IFN Induction. Autophagy 0 (0): 1–20.
https://doi.org/10.1080/15548627.2020.1758416.

2019

 Beilstein F, Cohen GH, Eisenberg RJ, Nicolas V, Esclatine A and Pasdeloup D (2019). Dynamic Organization of Herpesvirus Glycoproteins on the Viral Envelope Revealed by Super-Resolution Microscopy. PLoS Pathogens 15 (12): e1008209.
https://doi.org/10.1371/journal.ppat.1008209.

 Moris A, Pereira M and Chakrabarti L (2019). A Role for Antibodies in Natural HIV Control. Current Opinion in HIV and AIDS 14 (4): 265–72.
https://doi.org/10.1097/COH.0000000000000554.

 Poccardi N, Rousseau A, Haigh O, Takissian J, Naas T, Deback C, Trouillaud L, Issa M, Roubille S, Juillard F, Efstathiou S, Lomonte P and Labetoulle M (2019). Herpes Simplex Virus 1 Replication, Ocular Disease, and Reactivations from Latency Are Restricted Unilaterally after Inoculation of Virus into the Li. Journal of Virology 93 (24): e01586-19.
https://doi.org/10.1128/JVI.01586-19.

 Schönfeld M, Knackmuss U, Chandorkar P, Hörtnagl P, Hope TJ, Moris A, Bellmann-Weiler R, Lass-Flörl C, Posch W and Wilflingseder D (2019). Co- but Not Sequential Infection of DCs Boosts Their HIV-Specific CTL-Stimulatory Capacity. Frontiers in Immunology 10: 1123.
https://doi.org/10.3389/fimmu.2019.01123.

 Taisne C, Lussignol M, Hernández E, Moris A, Mouna L and Esclatine A (2019). Human Cytomegalovirus Hijacks the Autophagic Machinery and LC3 Homologs in Order to Optimize Cytoplasmic Envelopment of Mature Infectious Particles. Scientific Reports 9 (1): 4560.
https://doi.org/10.1038/s41598-019-41029-z.

2018

 Bendenoun M, Samri A, Avettand-Fènoël V, Cardinaud S, Descours B, Carcelain G, Mazeron M-C, Bergmann J-F, Urrutia A, Moris A, Rouzioux C, Simon F, Andre P, Pocard M, Dray X, Mourez T, Vieillard V, Autran B, Barin F and Sellier P (2018). What Is the most Important for Elite Control: Genetic Background of Patient, Genetic Background of Partner, both or neither? Description of Complete Natural History within a Couple of MSM. EbioMedecine 27: 51-60
https://doi.org/10.1016/j.ebiom.2017.12.003

 Cohen C, Corpet A, Roubille S, Maroui MA, Poccardi N, Rousseau A, Kleijwegt C, Binda O, Texier P, Sawtell N, Labetoulle M and Lomonte P (2018). Promyelocytic Leukemia (PML) Nuclear Bodies (NBs) Induce Latent/Quiescent HSV-1 Genomes Chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis. PLoS Pathogens 14 (9): e1007313.
https://doi.org/10.1371/journal.ppat.1007313.

 Colomer-Lluch M, Ruiz A, Moris A and Prado JG (2018). Restriction Factors: From Intrinsic Viral Restriction to Shaping Cellular Immunity Against HIV-1. Front Immunol 9:2876.
https://doi.org/10.3389/fimmu.2018.02876.

2017

 Cardinaud S, Urrutia A, Rouers A, Coulon PG, Kervevan J, Richetta C, Bet A, Atangana Maze E, Larsen M, Iglesias MC, Appay V, Graff-Dubois S and Moris A (2017). Triggering of TLR-3, -4, NOD2 and DC-SIGN reduces viral replication and increases T-cell activation capacity of HIV-infected human dendritic cells. Euro J. Immunol 47(5):818-829.
https://doi.org/10.1002/eji.201646603.

 Lussignol M and Esclatine A (2017). Herpesvirus and Autophagy: “All Right, Everybody Be Cool, This Is a Robbery!” Viruses 9 (12): 372.
https://doi.org/10.3390/v9120372.

 Monel B, Compton AA, Bruel T, Amraoui S, Burlaud-Gaillard J, Roy N, Guivel-Benhassine F, Porrot F, Génin P, Meertens L, Sinigaglia L, Jouvenet N, Weil R, Casartelli N, Demangel C, Simon-Lorière E, Moris A, Roingeard P, Amara A and Schwartz O (2017). Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells. EMBO J. 36:1653-1668.
https://doi.org/10.15252/embj.201695597).

 Rouers A, Jeger-Madiot R, Moris A and Graff-Dubois S (2017). Follicular helper T cells and HIV – United for better and worse. Médecine/Sciences 33(10):878-886.
https://doi.org/10.1051/medsci/20173310020.

 Rouers A, Klingler J, Su B, Samri A, Laumond G, Even S, Avettand-Fenoel V, Richetta C, Paul N, Boufassa F, Hocqueloux L, Mouquet H, Rouzioux C, Lambotte O, Autran B, Graff-Dubois S, Moog C and Moris A (2017). HIV-specific B cell frequency correlates with neutralization breadth in patients naturally controlling HIV-infection. EbioMedecine 21:158-169.
https://doi.org/10.1016/j.ebiom.2017.05.029.

 Silvin A, Yu CI, Lahaye X, Imperatore F, Brault JP, Cardinaud S, Becker C, Kwan WH, Conrad C, Maurin M, Goudot C, Marques-Ladeira S, Wang Y, Pascual V, Anguiano E, Albrecht RA, Iannacone M, García-Sastre A, Goud B, Dalod M, Moris A, Merad M, Palucka AK and Manel N (2017). Constitutive resistance to viral infection in human CD141+ dendritic cells. Sci. Immunol. 2 (13):8071.
https://doi.org/10.1126/sciimmunol.aai8071

 Vergne I, Lafont F, Espert L, Esclatine A and Biard-Piechaczyk M. (2017). Autophagie, Protéines ATG et Maladies Infectieuses. Médecine/Sciences 33 (3): 312–18.
https://doi.org/10.1051/medsci/20173303019.

 Xu Y, Phetsouphanh C, Suzuki K, Aggarwal A, Graff-Dubois S, Roche M, Bailey M, Alcantara S, Flanagan S, Cash K, Siva R, Koelsch KK, Autran B, Harvey R, Gorry PR, Moris A, Cooper DA, Turville S, Kent SJ, Kelleher and Zaunders J (2017). HIV-1 and SIV predominantly use CCR5 expressed on a precursor population to establish infection in T follicular helper cells. Frontiers in Immunol 8:376.
https://doi.org/10.3389/fimmu.2017.00376.

2016

 Caucheteux SM, Mitchell JP, Ivory MO, Hirosue S, Hakobyan S, Dolton G, Ladell K, Price D, Sewell A, Nestle F, Moris A, Karoo RO, Birchall JC, Hubbel JA, Blanchet FP and Piguet V (2016). A Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1. J Invest Dermatol. 136 (6):1172-81.
https://doi.org/10.1016/j.jid.2016.01.033

 Coulon PG, Richetta C, Rouers A, Blanchet FP, Urrutia U, Guerbois M, Piguet V, Theodorou I, Bet A, Schwartz O, Tangy F, Graff-Dubois S, Cardinaud S and Moris A (2016). HIV-infected dendritic cells present endogenous MHC-II-restricted antigens to HIV-specific CD4 + T cells. J. Immunol. 197(2):517-32.
https://doi.org/10.4049/jimmunol.1600286

 Graff-Dubois S, Rouers A and Moris A (2016). Impact of chronic HIV/SIV infection on germinal center reaction: lessons from analysis of T follicular cell subsets. Frontiers in Immunology 7:501.
https://doi.org/10.3389/fimmu.2016.00501

 Hamimi, C, David A, Versmisse P, Weiss L, Bruel T, Zucman D, Appay V, Moris A, Ungeheuer MN, Lascoux-Combe C, Barre-Sinoussi F, Muller-Trutwin M, Boufassa F, Lambotte O, Pancino G, Saez-Cirion A, and ACC cohort (2016). Dendritic Cells from HIV Controllers Have Low Susceptibility to HIV-1 Infection In Vitro but High Capacity to Capture HIV-1 Particles. PLoS One 11: e0160251.
https://doi.org/10.1371/journal.pone.0160251

 Jimenez E, Ruiz A, Kloverpris HN, Rodriguez-Plata MT, Pena R, Blondeau C, Selwood DL, Izquierdo-Useros N, Moris A, Clotet B, Goulder P, Towers GJ and Prado LG (2016). Non-human TRIM5 variants enhance recognition of HIV-1-infected cells by CD8+ T cells. J Virol 90 (19): 8552-8562.
http://doi.org/10.1128/JVI.00819-16

 Klionsky DJ et al., (2462 authors, including Moris A) (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1):1-222.
https://doi.org/10.1080/15548627.2015.1100356 .

 Maroui MA, Callé A, Cohen C, Streichenberger N, Texier P, Takissian J, Rousseau A Poccardi N, Welsch J, Corpet A, Schaeffer L, Labetoulle M and Lomonte P (2016). Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment. PLoS Pathogens 12 (9): e1005834.
https://doi.org/10.1371/journal.ppat.1005834.

 Mouna L, Hernandez E, Bonte D, Brost R, Amazit L, Delgui LR, Brune W, Geballe AP, Beau I and Esclatine A (2016). Analysis of the Role of Autophagy Inhibition by Two Complementary Human Cytomegalovirus BECN1/Beclin 1-Binding Proteins. Autophagy 12 (2): 327–42.
https://doi.org/10.1080/15548627.2015.1125071.

 Sicard A, Koenig A, Graff-Dubois S, Dussurgey S, Rouers A, Dubois V, Blanc P, Chartoire D, Errazuriz-Cerda E, Paidassi H, Taillardet M, Morelon E, Moris A, Defrance T and Thaunat O (2016). B Cells Loaded with Synthetic Particulate Antigens: A Versatile Platform to Generate Antigen-Specific Helper T Cells for Cell Therapy. Nano Lett. 16(1):297-308.
https://doi.org/10.1021/acs.nanolett.5b03801

 Siracusano G, Venuti A, Lombardo D, Mastino A, Esclatine A and Sciortino MT (2016). Early Activation of MyD88-Mediated Autophagy Sustains HSV-1 Replication in Human Monocytic THP-1 Cells. Scientific Reports 6: 31302.
https://doi.org/10.1038/srep31302.

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