Bacterial Cell Envelopes
and Antibiotics

Guérin, Hugo, Pascal Courtin, Alain Guillot, Christine Péchoux, Jennifer Mahony, Douwe van Sinderen, Saulius Kulakauskas, Christian Cambillau, Thierry Touzé, and Marie-Pierre Chapot-Chartier. 2023. “Molecular Mechanisms Underlying the Structural Diversity of Rhamnose-Rich Cell Wall Polysaccharides in Lactococci.” The Journal of Biological Chemistry, December, 105578. https://doi.org/10.1016/j.jbc.2023.105578.

Reuter, Jula, Christian Otten, Nicolas Jacquier, Junghoon Lee, Dominique Mengin-Lecreulx, Iris Löckener, Robert Kluj, et al. 2023. “An NlpC/P60 Protein Catalyzes a Key Step in Peptidoglycan Recycling at the Intersection of Energy Recovery, Cell Division and Immune Evasion in the Intracellular Pathogen Chlamydia Trachomatis.” PLoS Pathogens 19 (2): e1011047. https://doi.org/10.1371/journal.ppat.1011047.

Rietmeyer, Lauriane, Inès Li De La Sierra-Gallay, Guy Schepers, Delphine Dorchêne, Laura Iannazzo, Delphine Patin, Thierry Touzé, et al. 2022. “Amino-Acyl TXNA as Inhibitors or Amino Acid Donors in Peptide Synthesis.” Nucleic Acids Research, November, gkac1023. https://doi.org/10.1093/nar/gkac1023.

Jalalvand, Farshid, Yu-Ching Su, Guillaume Manat, Alexey Chernobrovkin, Mahendar Kadari, Sandra Jonsson, Martina Janousková, et al. 2022. “Protein Domain-Dependent Vesiculation of Lipoprotein A, a Protein That Is Important in Cell Wall Synthesis and Fitness of the Human Respiratory Pathogen Haemophilus Influenzae.” Frontiers in Cellular and Infection Microbiology 12 (October). https://www.frontiersin.org/articles/10.3389/fcimb.2022.984955.

Wan, Hongwei, Raja Ben Othman, Laurent Le Corre, Mélanie Poinsot, Martin Oliver, Ana Amoroso, Bernard Joris, et al. 2022. “New MraYAA Inhibitors with an Aminoribosyl Uridine Structure and an Oxadiazole.” Antibiotics 11 (9): 1189. https://doi.org/10.3390/antibiotics11091189.

Jukič, Marko, Rodolphe Auger, Victor Folcher, Matic Proj, Hélène Barreteau, Stanislav Gobec, and Thierry Touzé. 2022. “Towards Discovery of Inhibitors of the Undecaprenyl-Pyrophosphate Phosphatase BacA by Virtual High-Throughput Screening.” Computational and Structural Biotechnology Journal 20 (January):2360–71. https://doi.org/10.1016/j.csbj.2022.05.010.

Chérier, Dimitri, Delphine Patin, Didier Blanot, Thierry Touzé, and Hélène Barreteau. 2021. “The Biology of Colicin M and Its Orthologs.” Antibiotics (Basel, Switzerland) 10 (9): 1109. https://doi.org/10.3390/antibiotics10091109.

Ma, Miao, Margaux Lustig, Michèle Salem, Dominique Mengin-Lecreulx, Gilles Phan, and Isabelle Broutin. 2021. “MexAB-OprM Efflux Pump Interaction with the Peptidoglycan of Escherichia Coli and Pseudomonas Aeruginosa.” International Journal of Molecular Sciences 22 (10): 5328. https://doi.org/10.3390/ijms22105328.

Zellner, Briana, Dominique Mengin‐Lecreulx, Brenden Tully, William T. Gunning 3rd, Robert Booth, and Jason F. Huntley. 2021. “A Francisella Tularensis L,D-Carboxypeptidase Plays Important Roles in Cell Morphology, Envelope Integrity, and Virulence.” Molecular Microbiology n/a (n/a). https://doi.org/https://doi.org/10.1111/mmi.14685.

Delvaux, Cédric, Marjorie Dauvin, Madeleine Boulanger, Loïc Quinton, Dominique Mengin-Lecreulx, Bernard Joris, Edwin De Pauw, and Johann Far. 2021. “Use of Capillary Zone Electrophoresis Coupled to Electrospray Mass Spectrometry for the Detection and Absolute Quantitation of Peptidoglycan-Derived Peptides in Bacterial Cytoplasmic Extracts.” Analytical Chemistry, January. https://doi.org/10.1021/acs.analchem.0c04218.

Boes, Adrien, Frederic Kerff, Raphael Herman, Thierry Touze, Eefjan Breukink, and Mohammed Terrak. 2020. “The Bacterial Cell Division Protein Fragment EFtsN Binds to and Activates the Major Peptidoglycan Synthase PBP1b.” The Journal of Biological Chemistry 295 (52): 18256–65. https://doi.org/10.1074/jbc.RA120.015951.

Stone, M. Rhia L., Urszula Łapińska, Stefano Pagliara, Muriel Masi, Joanne T. Blanchfield, Matthew A. Cooper, and Mark A. T. Blaskovich. 2020. “Fluorescent Macrolide Probes - Synthesis and Use in Evaluation of Bacterial Resistance.” RSC Chemical Biology 1 (5): 395–404. https://doi.org/10.1039/d0cb00118j.

Barreteau, Hélène, Delphine Patin, Ahmed Bouhss, Didier Blanot, Dominique Mengin-Lecreulx, and Thierry Touzé. 2020. “CbrA Mediates Colicin M Resistance in Escherichia Coli through Modification of Undecaprenyl-Phosphate-Linked Peptidoglycan Precursors.” Journal of Bacteriology 202 (23): e00436-20. https://doi.org/10.1128/JB.00436-20.

Tian, Xudong, Rodolphe Auger, Guillaume Manat, Frédéric Kerff, Dominique Mengin-Lecreulx, and Thierry Touzé. 2020. “Insight into the Dual Function of Lipid Phosphate Phosphatase PgpB Involved in Two Essential Cell-Envelope Metabolic Pathways in Escherichia Coli.” Scientific Reports 10 (1): 13209. https://doi.org/10.1038/s41598-020-70047-5.

Boes, Adrien, Jean Michel Brunel, Adeline Derouaux, Frédéric Kerff, Ahmed Bouhss, Thierry Touze, Eefjan Breukink, and Mohammed Terrak. 2020. “Squalamine and Aminosterol Mimics Inhibit the Peptidoglycan Glycosyltransferase Activity of PBP1b.” Antibiotics (Basel, Switzerland) 9 (7): 373. https://doi.org/10.3390/antibiotics9070373.

Dietrich, Christiane, Ines Li de la Sierra-Gallay, Muriel Masi, Eric Girard, Nathalie Dautin, Florence Constantinesco-Becker, Maryelle Tropis, Mamadou Daffé, Herman van Tilbeurgh, and Nicolas Bayan. 2020. “The C-Terminal Domain of Corynebacterium Glutamicum Mycoloyltransferase A Is Composed of Five Repeated Motifs Involved in Cell Wall Binding and Stability.” Molecular Microbiology 114 (1): 1–16. https://doi.org/10.1111/mmi.14492.

Ammam, Fariza, Delphine Patin, Héloise Coullon, Didier Blanot, Thierry Lambert, Dominique Mengin-Lecreulx, and Thomas Candela. 2020. “AsnB Is Responsible for Peptidoglycan Precursor Amidation in Clostridium Difficile in the Presence of Vancomycin.” Microbiology (Reading, England) 166 (6): 567–78. https://doi.org/10.1099/mic.0.000917.

Vergalli, Julia, Alessio Atzori, Jelena Pajovic, Estelle Dumont, Giuliano Malloci, Muriel Masi, Attilio Vittorio Vargiu, et al. 2020. “The Challenge of Intracellular Antibiotic Accumulation, a Function of Fluoroquinolone Influx versus Bacterial Efflux.” Communications Biology 3 (1): 198. https://doi.org/10.1038/s42003-020-0929-x.

Rodgers, Faye H., Julia A. Cai, Andre N. Pitaluga, Dominique Mengin-Lecreulx, Mathilde Gendrin, and George K. Christophides. 2020. “Functional Analysis of the Three Major PGRPLC Isoforms in the Midgut of the Malaria Mosquito Anopheles Coluzzii.” Insect Biochemistry and Molecular Biology 118:103288. https://doi.org/10.1016/j.ibmb.2019.103288.

Vergalli, Julia, Igor V. Bodrenko, Muriel Masi, Lucile Moynié, Silvia Acosta-Gutiérrez, James H. Naismith, Anne Davin-Regli, et al. 2020. “Porins and Small-Molecule Translocation across the Outer Membrane of Gram-Negative Bacteria.” Nature Reviews. Microbiology 18 (3): 164–76. https://doi.org/10.1038/s41579-019-0294-2.

Gasiorowski, Elise, Rodolphe Auger, Xudong Tian, Samia Hicham, Chantal Ecobichon, Sophie Roure, Martin V. Douglass, et al. 2019. “HupA, the Main Undecaprenyl Pyrophosphate and Phosphatidylglycerol Phosphate Phosphatase in Helicobacter Pylori Is Essential for Colonization of the Stomach.” PLoS Pathogens 15 (9): e1007972. https://doi.org/10.1371/journal.ppat.1007972.

Latino, Libera, Delphine Patin, Dimitri Cherier, Thierry Touze, Christine Pourcel, Helene Barreteau, and Dominique Mengin-Lecreulx. 2019. “Impact of FiuA Outer Membrane Receptor Polymorphism on the Resistance of Pseudomonas Aeruginosa toward Peptidoglycan Lipid II-Targeting PaeM Pyocins.” Journal of Bacteriology 201 (13): e00164. https://doi.org/10.1128/JB.00164-19.

Massarweh, Ahmad, Michael Bosco, Isabelle Chantret, Thibaut Léger, Layla Jamal, David I. Roper, Christopher G. Dowson, et al. 2019. “Bacterial Lipid II Analogs: Novel In Vitro Substrates for Mammalian Oligosaccharyl Diphosphodolichol Diphosphatase (DLODP) Activities.” Molecules (Basel, Switzerland) 24 (11): 2135. https://doi.org/10.3390/molecules24112135.

Maire, Justin, Carole Vincent-Monegat, Severine Balmand, Agnes Vallier, Mireille Herve, Florent Masson, Nicolas Parisot, et al. 2019. “Weevil Pgrp-Lb Prevents Endosymbiont TCT Dissemination and Chronic Host Systemic Immune Activation.” Proceedings of the National Academy of Sciences of the United States of America 116 (12): 5623–32. https://doi.org/10.1073/pnas.1821806116.

Laddomada, Federica, Mayara M. Miyachiro, Matthew Jessop, Delphine Patin, Viviana Job, Dominique Mengin-Lecreulx, Aline Le Roy, et al. 2019. “The MurG Glycosyltransferase Provides an Oligomeric Scaffold for the Cytoplasmic Steps of Peptidoglycan Biosynthesis in the Human Pathogen Bordetella Pertussis.” Scientific Reports 9 (1): 4656. https://doi.org/10.1038/s41598-019-40966-z.

Barreteau, Helene, Manon Vandervennet, Laura Guedon, Vanessa Point, Stephane Canaan, Sylvie Rebuffat, Jean Peduzzi, and Alyssa Carre-Mlouka. 2019. “Haloarcula Sebkhae Sp. Nov., an Extremely Halophilic Archaeon from Algerian Hypersaline Environment.” International Journal of Systematic and Evolutionary Microbiology 69 (3): 732–38. https://doi.org/10.1099/ijsem.0.003211.

Tosi, Tommaso, Fumiya Hoshiga, Charlotte Millership, Rahul Singh, Charles Eldrid, Delphine Patin, Dominique Mengin-Lecreulx, Konstantinos Thalassinos, Paul Freemont, and Angelika Gründling. 2019. “Inhibition of the Staphylococcus Aureus C-Di-AMP Cyclase DacA by Direct Interaction with the Phosphoglucosamine Mutase GlmM.” PLoS Pathogens 15 (1): e1007537. https://doi.org/10.1371/journal.ppat.1007537.

Škedelj, Veronika, Urša Pečar Fonović, Peter Molek, Sophie Magnet, Jean-Luc Mainardi, Didier Blanot, Stanislav Gobec, Jure Stojan, and Anamarija Zega. 2019. “Kinetic Mechanism of Enterococcus Faecium D-Aspartate Ligase.” Biochimie 158 (January):217–23. https://doi.org/10.1016/j.biochi.2019.01.012.

Hrast, Martina, Kaja Rozman, Iza Ogris, Veronika Skedelj, Delphine Patin, Matej Sova, Helene Barreteau, Stanislav Gobec, Simona Golic Grdadolnik, and Anamarija Zega. 2019. “H Evaluation of the Published Kinase Inhibitor Set to Identify Multiple Inhibitors of Bacterial ATP-Dependent Mur Ligases.” Journal of Enzyme Inhibition and Medicinal Chemistry 34 (1): 1010–17. https://doi.org/10.1080/14756366.2019.1608981.

Abranyi-Balogh, Peter, Laszlo Petri, Timea Imre, Peter Szijj, Andrea Scarpino, Martina Hrast, Ana Mitrovic, et al. 2018. “A Road Map for Prioritizing Warheads for Cysteine Targeting Covalent Inhibitors.” European Journal of Medicinal Chemistry 160 (December):94–107. https://doi.org/10.1016/j.ejmech.2018.10.010.

Fonvielle, Matthieu, Ahmed Bouhss, Coralie Hoareau, Delphine Patin, Dominique Mengin-Lecreulx, Laura Iannazzo, Nicolas Sakkas, et al. 2018. “Synthesis of Lipid-Carbohydrate-Peptidyl-RNA Conjugates to Explore the Limits Imposed by the Substrate Specificity of Cell Wall Enzymes on the Acquisition of Drug Resistance.” Chemistry (Weinheim an Der Bergstrasse, Germany) 24 (56): 14911–15. https://doi.org/10.1002/chem.201802360.

Liu, Xiaolong, Nils Y. Meiresonne, Ahmed Bouhss, and Tanneke den Blaauwen. 2018. “FtsW Activity and Lipid II Synthesis Are Required for Recruitment of MurJ to Midcell during Cell Division in Escherichia Coli.” Molecular Microbiology 109 (6): 855–84. https://doi.org/10.1111/mmi.14104.

Ngadjeua, Flora, Emmanuelle Braud, Saidbakhrom Saidjalolov, Laura Iannazzo, Dirk Schnappinger, Sabine Ehrt, Jean-Emmanuel Hugonnet, et al. 2018. “Critical Impact of Peptidoglycan Precursor Amidation on the Activity of L,D-Transpeptidases from Enterococcus Faecium and Mycobacterium Tuberculosis.” Chemistry (Weinheim an Der Bergstrasse, Germany) 24 (February):5743–47. https://doi.org/10.1002/chem.201706082.

El Ghachi, Meriem, Nicole Howe, Chia-Ying Huang, Vincent Olieric, Rangana Warshamanage, Thierry Touzé, Dietmar Weichert, et al. 2018. “Crystal Structure of Undecaprenyl-Pyrophosphate Phosphatase and Its Role in Peptidoglycan Biosynthesis.” Nature Communications 9 (1): 1078. https://doi.org/10.1038/s41467-018-03477-5.

Pompeo, Frédérique, Deborah Byrne, Dominique Mengin-Lecreulx, and Anne Galinier. 2018. “Dual Regulation of Activity and Intracellular Localization of the PASTA Kinase PrkC during Bacillus Subtilis Growth.” Scientific Reports 8 (1): 1660. https://doi.org/10.1038/s41598-018-20145-2.

Hrast, Martina, Marko Jukič, Delphine Patin, Julie Tod, Christopher G. Dowson, David I. Roper, Hélène Barreteau, and Stanislav Gobec. 2018. “In Silico Identification, Synthesis and Biological Evaluation of Novel Tetrazole Inhibitors of MurB.” Chemical Biology & Drug Design 91 (6): 1101–12. https://doi.org/10.1111/cbdd.13172.

Fer, Mickael J., Laurent Le Corre, Nicolas Pietrancosta, Nathalie Evrard-Todeschi, Samir Olatunji, Ahmed Bouhss, Sandrine Calvet-Vitale, and Christine Gravier-Pelletier. 2018. “Bacterial Transferase MraY, a Source of Inspiration towards New Antibiotics.” Current Medicinal Chemistry 25 (42): 6013–29. https://doi.org/10.2174/0929867325666180330095154.

Jukič, Marko, Kaja Rožman, Matej Sova, Hélène Barreteau, and Stanislav Gobec. 2018. “Anthranilic Acid Inhibitors of Undecaprenyl Pyrophosphate Synthase (UppS), an Essential Enzyme for Bacterial Cell Wall Biosynthesis.” Frontiers in Microbiology 9:3322. https://doi.org/10.3389/fmicb.2018.03322.

Su, Ming-Yuan, Nilanjan Som, Chia-Yun Wu, Shih-Chieh Su, Yi-Ting Kuo, Lu-Chu Ke, Meng-Ru Ho, et al. 2017. “Structural Basis of Adaptor-Mediated Protein Degradation by the Tail-Specific PDZ-Protease Prc.” Nature Communications 8 (1): 1516. https://doi.org/10.1038/s41467-017-01697-9.

Hrast, Martina, Kaja Rožman, Marko Jukič, Delphine Patin, Stanislav Gobec, and Matej Sova. 2017. “Synthesis and Structure–Activity Relationship Study of Novel Quinazolinone-Based Inhibitors of MurA.” Bioorganic & Medicinal Chemistry Letters 27 (15): 3529–33. https://doi.org/10.1016/j.bmcl.2017.05.064.

Ghachi, Meriem El, Nicole Howe, Rodolphe Auger, Alexandre Lambion, Annick Guiseppi, François Delbrassine, Guillaume Manat, et al. 2017. “Crystal Structure and Biochemical Characterization of the Transmembrane PAP2 Type Phosphatidylglycerol Phosphate Phosphatase from Bacillus Subtilis.” Cellular and Molecular Life Sciences 74 (12): 2319–32. https://doi.org/10.1007/s00018-017-2464-6.

Rožman, Kaja, Samo Lešnik, Boris Brus, Martina Hrast, Matej Sova, Delphine Patin, Hélène Barreteau, Janez Konc, Dušanka Janežič, and Stanislav Gobec. 2017. “Discovery of New MurA Inhibitors Using Induced-Fit Simulation and Docking.” Bioorganic & Medicinal Chemistry Letters 27 (4): 944–49. https://doi.org/10.1016/j.bmcl.2016.12.082.

Bosco, Michaël, Ahmad Massarweh, Soria Iatmanen-Harbi, Ahmed Bouhss, Isabelle Chantret, Patricia Busca, Stuart E. H. Moore, and Christine Gravier-Pelletier. 2017. “Synthesis and Biological Evaluation of Chemical Tools for the Study of Dolichol Linked Oligosaccharide Diphosphatase (DLODP).” European Journal of Medicinal Chemistry 125 (January):952–64. https://doi.org/10.1016/j.ejmech.2016.10.013.

Di Gregorio, Sabrina, Silvina Fernandez, Arabela Cuirolo, Olivier Verlaine, Ana Amoroso, Dominique Mengin-Lecreulx, Angela Famiglietti, Bernard Joris, and Marta Mollerach. 2017. “Different Vancomycin-Intermediate Staphylococcus Aureus Phenotypes Selected from the Same ST100-HVISA Parental Strain.” Microbial Drug Resistance (Larchmont, N.Y.) 23 (1): 44–50. https://doi.org/10.1089/mdr.2016.0160.

Iatsenko, Igor, Shu Kondo, Dominique Mengin-Lecreulx, and Bruno Lemaitre. 2016. “PGRP-SD, an Extracellular Pattern-Recognition Receptor, Enhances Peptidoglycan-Mediated Activation of the Drosophila Imd Pathway.” Immunity 45 (5): 1013–23. https://doi.org/10.1016/j.immuni.2016.10.029.

Hugonnet, Jean-Emmanuel, Dominique Mengin-Lecreulx, Alejandro Monton, Tanneke den Blaauwen, Etienne Carbonnelle, Carole Veckerlé, Yves Brun V., et al. 2016. “Factors Essential for L,D-Transpeptidase-Mediated Peptidoglycan Cross-Linking and β-Lactam Resistance in Escherichia Coli.” Edited by Michael S Gilmore. ELife 5 (October):e19469. https://doi.org/10.7554/eLife.19469.

Fonvielle, Matthieu, Nicolas Sakkas, Laura Iannazzo, Chloé Le Fournis, Delphine Patin, Dominique Mengin-Lecreulx, Afaf El-Sagheer, et al. 2016. “Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with TRNA-Binding Enzymes.” Angewandte Chemie (International Ed. in English) 55 (43): 13553–57. https://doi.org/10.1002/anie.201606843.

Chérier, Dimitri, Sean Giacomucci, Delphine Patin, Ahmed Bouhss, Thierry Touzé, Didier Blanot, Dominique Mengin-Lecreulx, and Hélène Barreteau. 2016. “Pectocin M1 (PcaM1) Inhibits Escherichia Coli Cell Growth and Peptidoglycan Biosynthesis through Periplasmic Expression.” Antibiotics (Basel, Switzerland) 5 (4). https://doi.org/10.3390/antibiotics5040036.

Al-Dabbagh, Bayan, Samir Olatunji, Muriel Crouvoisier, Meriem El Ghachi, Didier Blanot, Dominique Mengin-Lecreulx, and Ahmed Bouhss. 2016. “Catalytic Mechanism of MraY and WecA, Two Paralogues of the Polyprenyl-Phosphate N-Acetylhexosamine 1-Phosphate Transferase Superfamily.” Biochimie 127 (August):249–57. https://doi.org/10.1016/j.biochi.2016.06.005.

Patin, Delphine, Samo Turk, Hélène Barreteau, Jean-Luc Mainardi, Michel Arthur, Stanislav Gobec, Dominique Mengin-Lecreulx, and Didier Blanot. 2016. “Unusual Substrate Specificity of the Peptidoglycan MurE Ligase from Erysipelothrix Rhusiopathiae.” Biochimie 121 (February):209–18. https://doi.org/10.1016/j.biochi.2015.12.006.