Bacterial Cell Envelopes
and Antibiotics

Publications

Zellner, Briana, Dominique Mengin‐Lecreulx, Brenden Tully, William T. Gunning 3rd, Robert Booth, and Jason F. Huntley. 2021. “A Francisella Tularensis L,D-Carboxypeptidase Plays Important Roles in Cell Morphology, Envelope Integrity, and Virulence.” Molecular Microbiology n/a (n/a). https://doi.org/https://doi.org/10.1111/mmi.14685.
Ma, Miao, Margaux Lustig, Michèle Salem, Dominique Mengin-Lecreulx, Gilles Phan, and Isabelle Broutin. 2021. “MexAB-OprM Efflux Pump Interaction with the Peptidoglycan of Escherichia Coli and Pseudomonas Aeruginosa.” International Journal of Molecular Sciences 22 (10): 5328. https://doi.org/10.3390/ijms22105328.
Delvaux, Cédric, Marjorie Dauvin, Madeleine Boulanger, Loïc Quinton, Dominique Mengin-Lecreulx, Bernard Joris, Edwin De Pauw, and Johann Far. 2021. “Use of Capillary Zone Electrophoresis Coupled to Electrospray Mass Spectrometry for the Detection and Absolute Quantitation of Peptidoglycan-Derived Peptides in Bacterial Cytoplasmic Extracts.” Analytical Chemistry, January. https://doi.org/10.1021/acs.analchem.0c04218.
Boes, Adrien, Frederic Kerff, Raphael Herman, Thierry Touze, Eefjan Breukink, and Mohammed Terrak. 2020. “The Bacterial Cell Division Protein Fragment EFtsN Binds to and Activates the Major Peptidoglycan Synthase PBP1b.” The Journal of Biological Chemistry 295 (52): 18256–65. https://doi.org/10.1074/jbc.RA120.015951.
Stone, M. Rhia L., Urszula Łapińska, Stefano Pagliara, Muriel Masi, Joanne T. Blanchfield, Matthew A. Cooper, and Mark A. T. Blaskovich. 2020. “Fluorescent Macrolide Probes - Synthesis and Use in Evaluation of Bacterial Resistance.” RSC Chemical Biology 1 (5): 395–404. https://doi.org/10.1039/d0cb00118j.
Barreteau, Hélène, Delphine Patin, Ahmed Bouhss, Didier Blanot, Dominique Mengin-Lecreulx, and Thierry Touzé. 2020. “CbrA Mediates Colicin M Resistance in Escherichia Coli through Modification of Undecaprenyl-Phosphate-Linked Peptidoglycan Precursors.” Journal of Bacteriology 202 (23): e00436-20. https://doi.org/10.1128/JB.00436-20.
Tian, Xudong, Rodolphe Auger, Guillaume Manat, Frédéric Kerff, Dominique Mengin-Lecreulx, and Thierry Touzé. 2020. “Insight into the Dual Function of Lipid Phosphate Phosphatase PgpB Involved in Two Essential Cell-Envelope Metabolic Pathways in Escherichia Coli.” Scientific Reports 10 (1): 13209. https://doi.org/10.1038/s41598-020-70047-5.
Boes, Adrien, Jean Michel Brunel, Adeline Derouaux, Frédéric Kerff, Ahmed Bouhss, Thierry Touze, Eefjan Breukink, and Mohammed Terrak. 2020. “Squalamine and Aminosterol Mimics Inhibit the Peptidoglycan Glycosyltransferase Activity of PBP1b.” Antibiotics (Basel, Switzerland) 9 (7): 373. https://doi.org/10.3390/antibiotics9070373.
Dietrich, Christiane, Ines Li de la Sierra-Gallay, Muriel Masi, Eric Girard, Nathalie Dautin, Florence Constantinesco-Becker, Maryelle Tropis, Mamadou Daffé, Herman van Tilbeurgh, and Nicolas Bayan. 2020. “The C-Terminal Domain of Corynebacterium Glutamicum Mycoloyltransferase A Is Composed of Five Repeated Motifs Involved in Cell Wall Binding and Stability.” Molecular Microbiology 114 (1): 1–16. https://doi.org/10.1111/mmi.14492.
Ammam, Fariza, Delphine Patin, Héloise Coullon, Didier Blanot, Thierry Lambert, Dominique Mengin-Lecreulx, and Thomas Candela. 2020. “AsnB Is Responsible for Peptidoglycan Precursor Amidation in Clostridium Difficile in the Presence of Vancomycin.” Microbiology (Reading, England) 166 (6): 567–78. https://doi.org/10.1099/mic.0.000917.
Vergalli, Julia, Alessio Atzori, Jelena Pajovic, Estelle Dumont, Giuliano Malloci, Muriel Masi, Attilio Vittorio Vargiu, et al. 2020. “The Challenge of Intracellular Antibiotic Accumulation, a Function of Fluoroquinolone Influx versus Bacterial Efflux.” Communications Biology 3 (1): 198. https://doi.org/10.1038/s42003-020-0929-x.
Vergalli, Julia, Igor V. Bodrenko, Muriel Masi, Lucile Moynié, Silvia Acosta-Gutiérrez, James H. Naismith, Anne Davin-Regli, et al. 2020. “Porins and Small-Molecule Translocation across the Outer Membrane of Gram-Negative Bacteria.” Nature Reviews. Microbiology 18 (3): 164–76. https://doi.org/10.1038/s41579-019-0294-2.
Rodgers, Faye H., Julia A. Cai, Andre N. Pitaluga, Dominique Mengin-Lecreulx, Mathilde Gendrin, and George K. Christophides. 2020. “Functional Analysis of the Three Major PGRPLC Isoforms in the Midgut of the Malaria Mosquito Anopheles Coluzzii.” Insect Biochemistry and Molecular Biology 118: 103288. https://doi.org/10.1016/j.ibmb.2019.103288.
Gasiorowski, Elise, Rodolphe Auger, Xudong Tian, Samia Hicham, Chantal Ecobichon, Sophie Roure, Martin V. Douglass, et al. 2019. “HupA, the Main Undecaprenyl Pyrophosphate and Phosphatidylglycerol Phosphate Phosphatase in Helicobacter Pylori Is Essential for Colonization of the Stomach.” PLoS Pathogens 15 (9): e1007972. https://doi.org/10.1371/journal.ppat.1007972.
Latino, Libera, Delphine Patin, Dimitri Cherier, Thierry Touze, Christine Pourcel, Helene Barreteau, and Dominique Mengin-Lecreulx. 2019. “Impact of FiuA Outer Membrane Receptor Polymorphism on the Resistance of Pseudomonas Aeruginosa toward Peptidoglycan Lipid II-Targeting PaeM Pyocins.” Journal of Bacteriology 201 (13): e00164. https://doi.org/10.1128/JB.00164-19.
Massarweh, Ahmad, Michael Bosco, Isabelle Chantret, Thibaut Léger, Layla Jamal, David I. Roper, Christopher G. Dowson, et al. 2019. “Bacterial Lipid II Analogs: Novel In Vitro Substrates for Mammalian Oligosaccharyl Diphosphodolichol Diphosphatase (DLODP) Activities.” Molecules (Basel, Switzerland) 24 (11): 2135. https://doi.org/10.3390/molecules24112135.
Maire, Justin, Carole Vincent-Monegat, Severine Balmand, Agnes Vallier, Mireille Herve, Florent Masson, Nicolas Parisot, et al. 2019. “Weevil Pgrp-Lb Prevents Endosymbiont TCT Dissemination and Chronic Host Systemic Immune Activation.” Proceedings of the National Academy of Sciences of the United States of America 116 (12): 5623–32. https://doi.org/10.1073/pnas.1821806116.
Laddomada, Federica, Mayara M. Miyachiro, Matthew Jessop, Delphine Patin, Viviana Job, Dominique Mengin-Lecreulx, Aline Le Roy, et al. 2019. “The MurG Glycosyltransferase Provides an Oligomeric Scaffold for the Cytoplasmic Steps of Peptidoglycan Biosynthesis in the Human Pathogen Bordetella Pertussis.” Scientific Reports 9 (1): 4656. https://doi.org/10.1038/s41598-019-40966-z.
Barreteau, Helene, Manon Vandervennet, Laura Guedon, Vanessa Point, Stephane Canaan, Sylvie Rebuffat, Jean Peduzzi, and Alyssa Carre-Mlouka. 2019. “Haloarcula Sebkhae Sp. Nov., an Extremely Halophilic Archaeon from Algerian Hypersaline Environment.” International Journal of Systematic and Evolutionary Microbiology 69 (3): 732–38. https://doi.org/10.1099/ijsem.0.003211.
Tosi, Tommaso, Fumiya Hoshiga, Charlotte Millership, Rahul Singh, Charles Eldrid, Delphine Patin, Dominique Mengin-Lecreulx, Konstantinos Thalassinos, Paul Freemont, and Angelika Gründling. 2019. “Inhibition of the Staphylococcus Aureus C-Di-AMP Cyclase DacA by Direct Interaction with the Phosphoglucosamine Mutase GlmM.” PLoS Pathogens 15 (1): e1007537. https://doi.org/10.1371/journal.ppat.1007537.
Škedelj, Veronika, Urša Pečar Fonović, Peter Molek, Sophie Magnet, Jean-Luc Mainardi, Didier Blanot, Stanislav Gobec, Jure Stojan, and Anamarija Zega. 2019. “Kinetic Mechanism of Enterococcus Faecium D-Aspartate Ligase.” Biochimie 158 (January): 217–23. https://doi.org/10.1016/j.biochi.2019.01.012.
Hrast, Martina, Kaja Rozman, Iza Ogris, Veronika Skedelj, Delphine Patin, Matej Sova, Helene Barreteau, Stanislav Gobec, Simona Golic Grdadolnik, and Anamarija Zega. 2019. “H Evaluation of the Published Kinase Inhibitor Set to Identify Multiple Inhibitors of Bacterial ATP-Dependent Mur Ligases.” Journal of Enzyme Inhibition and Medicinal Chemistry 34 (1): 1010–17. https://doi.org/10.1080/14756366.2019.1608981.
Abranyi-Balogh, Peter, Laszlo Petri, Timea Imre, Peter Szijj, Andrea Scarpino, Martina Hrast, Ana Mitrovic, et al. 2018. “A Road Map for Prioritizing Warheads for Cysteine Targeting Covalent Inhibitors.” European Journal of Medicinal Chemistry 160 (December): 94–107. https://doi.org/10.1016/j.ejmech.2018.10.010.
Fonvielle, Matthieu, Ahmed Bouhss, Coralie Hoareau, Delphine Patin, Dominique Mengin-Lecreulx, Laura Iannazzo, Nicolas Sakkas, et al. 2018. “Synthesis of Lipid-Carbohydrate-Peptidyl-RNA Conjugates to Explore the Limits Imposed by the Substrate Specificity of Cell Wall Enzymes on the Acquisition of Drug Resistance.” Chemistry (Weinheim an Der Bergstrasse, Germany) 24 (56): 14911–15. https://doi.org/10.1002/chem.201802360.
Liu, Xiaolong, Nils Y. Meiresonne, Ahmed Bouhss, and Tanneke den Blaauwen. 2018. “FtsW Activity and Lipid II Synthesis Are Required for Recruitment of MurJ to Midcell during Cell Division in Escherichia Coli.” Molecular Microbiology 109 (6): 855–84. https://doi.org/10.1111/mmi.14104.
Ngadjeua, Flora, Emmanuelle Braud, Saidbakhrom Saidjalolov, Laura Iannazzo, Dirk Schnappinger, Sabine Ehrt, Jean-Emmanuel Hugonnet, et al. 2018. “Critical Impact of Peptidoglycan Precursor Amidation on the Activity of L,D-Transpeptidases from Enterococcus Faecium and Mycobacterium Tuberculosis.” Chemistry (Weinheim an Der Bergstrasse, Germany) 24 (February): 5743–47. https://doi.org/10.1002/chem.201706082.
El Ghachi, Meriem, Nicole Howe, Chia-Ying Huang, Vincent Olieric, Rangana Warshamanage, Thierry Touzé, Dietmar Weichert, et al. 2018. “Crystal Structure of Undecaprenyl-Pyrophosphate Phosphatase and Its Role in Peptidoglycan Biosynthesis.” Nature Communications 9 (1): 1078. https://doi.org/10.1038/s41467-018-03477-5.
Pompeo, Frédérique, Deborah Byrne, Dominique Mengin-Lecreulx, and Anne Galinier. 2018. “Dual Regulation of Activity and Intracellular Localization of the PASTA Kinase PrkC during Bacillus Subtilis Growth.” Scientific Reports 8 (1): 1660. https://doi.org/10.1038/s41598-018-20145-2.
Hrast, Martina, Marko Jukič, Delphine Patin, Julie Tod, Christopher G. Dowson, David I. Roper, Hélène Barreteau, and Stanislav Gobec. 2018. “In Silico Identification, Synthesis and Biological Evaluation of Novel Tetrazole Inhibitors of MurB.” Chemical Biology & Drug Design 91 (6): 1101–12. https://doi.org/10.1111/cbdd.13172.
Fer, Mickael J., Laurent Le Corre, Nicolas Pietrancosta, Nathalie Evrard-Todeschi, Samir Olatunji, Ahmed Bouhss, Sandrine Calvet-Vitale, and Christine Gravier-Pelletier. 2018. “Bacterial Transferase MraY, a Source of Inspiration towards New Antibiotics.” Current Medicinal Chemistry 25 (42): 6013–29. https://doi.org/10.2174/0929867325666180330095154.
Jukič, Marko, Kaja Rožman, Matej Sova, Hélène Barreteau, and Stanislav Gobec. 2018. “Anthranilic Acid Inhibitors of Undecaprenyl Pyrophosphate Synthase (UppS), an Essential Enzyme for Bacterial Cell Wall Biosynthesis.” Frontiers in Microbiology 9: 3322. https://doi.org/10.3389/fmicb.2018.03322.
Su, Ming-Yuan, Nilanjan Som, Chia-Yun Wu, Shih-Chieh Su, Yi-Ting Kuo, Lu-Chu Ke, Meng-Ru Ho, et al. 2017. “Structural Basis of Adaptor-Mediated Protein Degradation by the Tail-Specific PDZ-Protease Prc.” Nature Communications 8 (1): 1516. https://doi.org/10.1038/s41467-017-01697-9.
Hrast, Martina, Kaja Rožman, Marko Jukič, Delphine Patin, Stanislav Gobec, and Matej Sova. 2017. “Synthesis and Structure–Activity Relationship Study of Novel Quinazolinone-Based Inhibitors of MurA.” Bioorganic & Medicinal Chemistry Letters 27 (15): 3529–33. https://doi.org/10.1016/j.bmcl.2017.05.064.
Ghachi, Meriem El, Nicole Howe, Rodolphe Auger, Alexandre Lambion, Annick Guiseppi, François Delbrassine, Guillaume Manat, et al. 2017. “Crystal Structure and Biochemical Characterization of the Transmembrane PAP2 Type Phosphatidylglycerol Phosphate Phosphatase from Bacillus Subtilis.” Cellular and Molecular Life Sciences 74 (12): 2319–32. https://doi.org/10.1007/s00018-017-2464-6.
Rožman, Kaja, Samo Lešnik, Boris Brus, Martina Hrast, Matej Sova, Delphine Patin, Hélène Barreteau, Janez Konc, Dušanka Janežič, and Stanislav Gobec. 2017. “Discovery of New MurA Inhibitors Using Induced-Fit Simulation and Docking.” Bioorganic & Medicinal Chemistry Letters 27 (4): 944–49. https://doi.org/10.1016/j.bmcl.2016.12.082.
Bosco, Michaël, Ahmad Massarweh, Soria Iatmanen-Harbi, Ahmed Bouhss, Isabelle Chantret, Patricia Busca, Stuart E. H. Moore, and Christine Gravier-Pelletier. 2017. “Synthesis and Biological Evaluation of Chemical Tools for the Study of Dolichol Linked Oligosaccharide Diphosphatase (DLODP).” European Journal of Medicinal Chemistry 125 (January): 952–64. https://doi.org/10.1016/j.ejmech.2016.10.013.
Di Gregorio, Sabrina, Silvina Fernandez, Arabela Cuirolo, Olivier Verlaine, Ana Amoroso, Dominique Mengin-Lecreulx, Angela Famiglietti, Bernard Joris, and Marta Mollerach. 2017. “Different Vancomycin-Intermediate Staphylococcus Aureus Phenotypes Selected from the Same ST100-HVISA Parental Strain.” Microbial Drug Resistance (Larchmont, N.Y.) 23 (1): 44–50. https://doi.org/10.1089/mdr.2016.0160.
Iatsenko, Igor, Shu Kondo, Dominique Mengin-Lecreulx, and Bruno Lemaitre. 2016. “PGRP-SD, an Extracellular Pattern-Recognition Receptor, Enhances Peptidoglycan-Mediated Activation of the Drosophila Imd Pathway.” Immunity 45 (5): 1013–23. https://doi.org/10.1016/j.immuni.2016.10.029.
Hugonnet, Jean-Emmanuel, Dominique Mengin-Lecreulx, Alejandro Monton, Tanneke den Blaauwen, Etienne Carbonnelle, Carole Veckerlé, Yves Brun V., et al. 2016. “Factors Essential for L,D-Transpeptidase-Mediated Peptidoglycan Cross-Linking and β-Lactam Resistance in Escherichia Coli.” Edited by Michael S Gilmore. ELife 5 (October): e19469. https://doi.org/10.7554/eLife.19469.
Fonvielle, Matthieu, Nicolas Sakkas, Laura Iannazzo, Chloé Le Fournis, Delphine Patin, Dominique Mengin-Lecreulx, Afaf El-Sagheer, et al. 2016. “Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with TRNA-Binding Enzymes.” Angewandte Chemie (International Ed. in English) 55 (43): 13553–57. https://doi.org/10.1002/anie.201606843.
Chérier, Dimitri, Sean Giacomucci, Delphine Patin, Ahmed Bouhss, Thierry Touzé, Didier Blanot, Dominique Mengin-Lecreulx, and Hélène Barreteau. 2016. “Pectocin M1 (PcaM1) Inhibits Escherichia Coli Cell Growth and Peptidoglycan Biosynthesis through Periplasmic Expression.” Antibiotics (Basel, Switzerland) 5 (4). https://doi.org/10.3390/antibiotics5040036.
Al-Dabbagh, Bayan, Samir Olatunji, Muriel Crouvoisier, Meriem El Ghachi, Didier Blanot, Dominique Mengin-Lecreulx, and Ahmed Bouhss. 2016. “Catalytic Mechanism of MraY and WecA, Two Paralogues of the Polyprenyl-Phosphate N-Acetylhexosamine 1-Phosphate Transferase Superfamily.” Biochimie 127 (August): 249–57. https://doi.org/10.1016/j.biochi.2016.06.005.
Patin, Delphine, Samo Turk, Hélène Barreteau, Jean-Luc Mainardi, Michel Arthur, Stanislav Gobec, Dominique Mengin-Lecreulx, and Didier Blanot. 2016. “Unusual Substrate Specificity of the Peptidoglycan MurE Ligase from Erysipelothrix Rhusiopathiae.” Biochimie 121 (February): 209–18. https://doi.org/10.1016/j.biochi.2015.12.006.
Šink, Roman, Miha Kotnik, Anamarija Zega, Hélène Barreteau, Stanislav Gobec, Didier Blanot, Andréa Dessen, and Carlos Contreras-Martel. 2016. “Crystallographic Study of Peptidoglycan Biosynthesis Enzyme MurD: Domain Movement Revisited.” PloS One 11 (3): e0152075. https://doi.org/10.1371/journal.pone.0152075.
Naqvi, Kubra F., Delphine Patin, Matthew S. Wheatley, Michael A. Savka, Renwick C. J. Dobson, Han Ming Gan, Hélène Barreteau, Didier Blanot, Dominique Mengin-Lecreulx, and André O. Hudson. 2016. “Identification and Partial Characterization of a Novel UDP-N-Acetylenolpyruvoylglucosamine Reductase/UDP-N-Acetylmuramate:L-Alanine Ligase Fusion Enzyme from Verrucomicrobium Spinosum DSM 4136(T).” Frontiers in Microbiology 7: 362. https://doi.org/10.3389/fmicb.2016.00362.
Xu, Qingping, Dominique Mengin-Lecreulx, Xueqian W. Liu, Delphine Patin, Carol L. Farr, Joanna C. Grant, Hsiu-Ju Chiu, et al. 2015. “Insights into Substrate Specificity of NlpC/P60 Cell Wall Hydrolases Containing Bacterial SH3 Domains.” MBio 6 (5): e02327-02314. https://doi.org/10.1128/mBio.02327-14.
Fer, Mickaël J., Ahmed Bouhss, Mariana Patrão, Laurent Le Corre, Nicolas Pietrancosta, Ana Amoroso, Bernard Joris, Dominique Mengin-Lecreulx, Sandrine Calvet-Vitale, and Christine Gravier-Pelletier. 2015. “5’-Methylene-Triazole-Substituted-Aminoribosyl Uridines as MraY Inhibitors: Synthesis, Biological Evaluation and Molecular Modeling.” Organic & Biomolecular Chemistry 13 (26): 7193–7222. https://doi.org/10.1039/c5ob00707k.
Perdih, Andrej, Martina Hrast, Kaja Pureber, Hélène Barreteau, Simona Golič Grdadolnik, Darko Kocjan, Stanislav Gobec, Tom Solmajer, and Gerhard Wolber. 2015. “Furan-Based Benzene Mono- and Dicarboxylic Acid Derivatives as Multiple Inhibitors of the Bacterial Mur Ligases (MurC-MurF): Experimental and Computational Characterization.” Journal of Computer-Aided Molecular Design 29 (6): 541–60. https://doi.org/10.1007/s10822-015-9843-6.
Levefaudes, Marjorie, Delphine Patin, Célia de Sousa-d’Auria, Mohamed Chami, Didier Blanot, Mireille Hervé, Michel Arthur, Christine Houssin, and Dominique Mengin-Lecreulx. 2015. “Diaminopimelic Acid Amidation in Corynebacteriales: NEW INSIGHTS INTO THE ROLE OF LtsA IN PEPTIDOGLYCAN MODIFICATION.” The Journal of Biological Chemistry 290 (21): 13079–94. https://doi.org/10.1074/jbc.M115.642843.
Soudais, Claire, Fatoumata Samassa, Manal Sarkis, Lionel Le Bourhis, Stéphanie Bessoles, Didier Blanot, Mireille Hervé, Frédéric Schmidt, Dominique Mengin-Lecreulx, and Olivier Lantz. 2015. “In Vitro and In Vivo Analysis of the Gram-Negative Bacteria-Derived Riboflavin Precursor Derivatives Activating Mouse MAIT Cells.” Journal of Immunology (Baltimore, Md.: 1950) 194 (10): 4641–49. https://doi.org/10.4049/jimmunol.1403224.
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