Calcium Signaling and Microbial Infections

Publications

  Role of astrogial Connexin 43 in pneumococcal meningitis and pneumolysin cytotoxicity. Bello C, Smail Y, Sainte-Rose V, Podglajen I, Gilbert A, Moreira V, Chrétien F, Cohen-Salmon M, Tran Van Nhieu G. PLoS Pathogens 2020, 28;16(12):e1009152.
doi: 10.1371/journal.ppat.1009152.

  Valencia-Gallardo C, Bou-Nader C, Aguilar D, Carayol N, Quenech’Du N, Pecqueur L, Park HJ, Fontecave M, Izard T, Tran Van Nhieu G. Shigella IpaA binding to talin stimulates filopodial capture and cell adhesion. Cell Reports, 2019 Jan 22;26(4):921-932.e6.
doi: 10.1016/j.celrep.2018.12.091.

  Collet C, Thomassin JL, Francetic O, Genevaux P, Tran Van Nhieu G. Protein polarization driven by nucleoid occlusion of DnaK (Hsp70)-substrate complexes. (2018) Nature Communications. (23;9(1):2027.
doi: 10.1038/s41467-018-04414-2.

  Sun CH, Wacquier B, Aguilar D, Carayol N, Denis K, Boucherie S, Valencia-Gallardo C, Simsek C, Erneux C, Lehman A, Enninga J, Arbibe L, Sansonetti P, Dupont G, Combettes L, Tran Van Nhieu G. (2017). The Shigella type III effector IpgD recodes Ca2+ signals during invasion of epithelial cells. The EMBO Journal. 2017. 36(17):2567-2580.
doi: 10.15252/embj.201696272

  Guignot J, Segura A, Tran Van Nhieu G. The serine protease EspC from Enteropathogenic Escherichia coli regulates pore formation and cytotoxicity mediated by the Type III Secretion System. PLoS Pathog. 2015 Jul 1;11(7):e1005013.
doi: 10.1371/journal.ppat.1005013.

  Tran Van Nhieu G, Liu B.K, Zheng J, Pierre F, Prigent S, Sansonetti P, Erneux C, Jung Kuk K, Pann-Ghill S, Dupont G, Combettes L. Actin-based confinement of calcium responses during Shigella invasion. Nature Communications. 2013 Mar 5;4:1567.
doi: 10.1038/ncomms2561.

  Romero S, Grompone G, Carayol N, Mounier J, Guadagnini S, Prevost MC, Sansonetti PJ, Tran Van Nhieu G. ATP-mediated Erk1/2 activation stimulates bacterial capture by filopodia, which precedes Shigella invasion of epithelial cells. Cell Host Microbe. 2011 Jun 16;9(6):508-19.
doi: 10.1016/j.chom.2011.05.005. PMID: 21669399; PMCID: PMC4425278.

  Jaumouillé, V, Francetic, O, Sansonetti, P, Tran Van Nhieu, G. (2008). Cytoplasmic targeting of IpaC to the bacterial pole directs polar type III secretion in Shigella. EMBO Journal. 27 :447-457.

  Enninga, J, Mounier, J., Sansonetti, PJ, Tran Van Nhieu G. (2005).  Secretion of type III effectors into host cells in real time. Nature Methods. 12 : 959-965.

  Tran Van Nhieu G, Clair C, Mesnil M, Bruzzone R, Sansonetti P, Combettes L. Connexin-dependent intercellular communication stimulates Shigella dissemination in epithelial cells. Nature Cell Biol. 2003, 5 (8), 720-726.

Valorisation

N°PVT/ EP2016/073287. 2016. International Phase. Polypeptides comprising vinculin-binding sites for the treatment of proliferation and/or adhesion related diseases. Inventors: Valencia-Gallardo C, Quenech’Du N, Tran Van Nhieu G. Idex PSL-CNRS-Inserm

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