Calcium Signaling and Microbial Infections


Yao, Mingxi, Ajay Tijore, Delfine Cheng, Jinyuan Vero Li, Anushya Hariharan, Boris Martinac, Guy Tran Van Nhieu, Charles D. Cox, and Michael Sheetz. 2022. “Force- and Cell State–Dependent Recruitment of Piezo1 Drives Focal Adhesion Dynamics and Calcium Entry.” Science Advances 8 (45): eabo1461.
Tran Van Nhieu, Guy, Patricia Latour-Lambert, and Jost Enninga. 2022. “Modification of Phosphoinositides by the Shigella Effector IpgD during Host Cell Infection.” Frontiers in Cellular and Infection Microbiology 12 (October).
Liu, Liyun, Liqiong Song, Rong Deng, Ruiting Lan, Wenjie Jin, Guy Tran Van Nhieu, Huifang Cao, et al. 2021. “Citrobacter Freundii Activation of NLRP3 Inflammasome via the Type VI Secretion System.” The Journal of Infectious Diseases 223 (12): 2174–85.
Bello, Chakir, Yasmine Smail, Vincent Sainte-Rose, Isabelle Podglajen, Alice Gilbert, Vanessa Moreira, Fabrice Chrétien, Martine Cohen Salmon, and Guy Tran Van Nhieu. 2020. “Role of Astroglial Connexin 43 in Pneumolysin Cytotoxicity and during Pneumococcal Meningitis.” PLOS Pathogens 16 (12): e1009152.

selected publications 2016 – 2019

  Valencia-Gallardo C, Bou-Nader C, Aguilar D, Carayol N, Quenech’Du N, Pecqueur L, Park HJ, Fontecave M, Izard T, Tran Van Nhieu G. Shigella IpaA binding to talin stimulates filopodial capture and cell adhesion. Cell Reports, 2019 Jan 22;26(4):921-932.e6.
doi: 10.1016/j.celrep.2018.12.091.

  Collet C, Thomassin JL, Francetic O, Genevaux P, Tran Van Nhieu G. Protein polarization driven by nucleoid occlusion of DnaK (Hsp70)-substrate complexes. (2018) Nature Communications. (23;9(1):2027.
doi: 10.1038/s41467-018-04414-2.

  Sun CH, Wacquier B, Aguilar D, Carayol N, Denis K, Boucherie S, Valencia-Gallardo C, Simsek C, Erneux C, Lehman A, Enninga J, Arbibe L, Sansonetti P, Dupont G, Combettes L, Tran Van Nhieu G. (2017). The Shigella type III effector IpgD recodes Ca2+ signals during invasion of epithelial cells. The EMBO Journal. 2017. 36(17):2567-2580.
doi: 10.15252/embj.201696272

  Guignot J, Segura A, Tran Van Nhieu G. The serine protease EspC from Enteropathogenic Escherichia coli regulates pore formation and cytotoxicity mediated by the Type III Secretion System. PLoS Pathog. 2015 Jul 1;11(7):e1005013.
doi: 10.1371/journal.ppat.1005013.

  Tran Van Nhieu G, Liu B.K, Zheng J, Pierre F, Prigent S, Sansonetti P, Erneux C, Jung Kuk K, Pann-Ghill S, Dupont G, Combettes L. Actin-based confinement of calcium responses during Shigella invasion. Nature Communications. 2013 Mar 5;4:1567.
doi: 10.1038/ncomms2561.

  Romero S, Grompone G, Carayol N, Mounier J, Guadagnini S, Prevost MC, Sansonetti PJ, Tran Van Nhieu G. ATP-mediated Erk1/2 activation stimulates bacterial capture by filopodia, which precedes Shigella invasion of epithelial cells. Cell Host Microbe. 2011 Jun 16;9(6):508-19.
doi: 10.1016/j.chom.2011.05.005. PMID: 21669399; PMCID: PMC4425278.

  Jaumouillé, V, Francetic, O, Sansonetti, P, Tran Van Nhieu, G. (2008). Cytoplasmic targeting of IpaC to the bacterial pole directs polar type III secretion in Shigella. EMBO Journal. 27 :447-457.

  Enninga, J, Mounier, J., Sansonetti, PJ, Tran Van Nhieu G. (2005).  Secretion of type III effectors into host cells in real time. Nature Methods. 12 : 959-965.

  Tran Van Nhieu G, Clair C, Mesnil M, Bruzzone R, Sansonetti P, Combettes L. Connexin-dependent intercellular communication stimulates Shigella dissemination in epithelial cells. Nature Cell Biol. 2003, 5 (8), 720-726.


N°PVT/ EP2016/073287. 2016. International Phase. Polypeptides comprising vinculin-binding sites for the treatment of proliferation and/or adhesion related diseases. Inventors: Valencia-Gallardo C, Quenech’Du N, Tran Van Nhieu G. Idex PSL-CNRS-Inserm

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