Function and architecture
of macromolecular assemblies

Publications

Léger, Corentin, Irène Pitard, Mirko Sadi, Nicolas Carvalho, Sébastien Brier, Ariel Mechaly, Dorothée Raoux-Barbot, et al. 2022. “Dynamics and Structural Changes of Calmodulin upon Interaction with the Antagonist Calmidazolium.” BMC Biology 20 (1): 176. https://doi.org/10.1186/s12915-022-01381-5.
Lazar, Noureddine, Carl H. Mesarich, Yohann Petit-Houdenot, Nacera Talbi, Ines Li de la Sierra-Gallay, Emilie Zélie, Karine Blondeau, et al. 2022. “A New Family of Structurally Conserved Fungal Effectors Displays Epistatic Interactions with Plant Resistance Proteins.” PLOS Pathogens 18 (7): e1010664. https://doi.org/10.1371/journal.ppat.1010664.
Cargemel, Claire, Hélène Walbott, Dominique Durand, Pierre Legrand, Malika Ouldali, Jean-Luc Ferat, Stéphanie Marsin, and Sophie Quevillon-Cheruel. 2022. “The Apo-Form of the Vibrio Cholerae Replicative Helicase DnaB Is a Labile and Inactive Planar Trimer of Dimers.” FEBS Letters n/a (n/a). https://doi.org/10.1002/1873-3468.14403.
Damke, Prashant P., Louisa Celma, Sumedha M. Kondekar, Anne Marie Di Guilmi, Stéphanie Marsin, Jordane Dépagne, Xavier Veaute, et al. 2022. “ComFC Mediates Transport and Handling of Single-Stranded DNA during Natural Transformation.” Nature Communications 13 (1): 1961. https://doi.org/10.1038/s41467-022-29494-z.
Mao, Wei, Noureddine Lazar, Herman van Tilbeurgh, Philippe M. Loiseau, and Sébastien Pomel. 2022. “Minor Impact of A258D Mutation on Biochemical and Enzymatic Properties of Leishmania Infantum GDP-Mannose Pyrophosphorylase.” Microorganisms 10 (2): 231. https://doi.org/10.3390/microorganisms10020231.
Ledesma-García, Laura, Imke Ensinck, Denis Dereinne, Felipe Viela, Johann Mignolet, Yves F. Dufrêne, Patrice Soumillion, Sylvie Nessler, and Pascal Hols. 2021. “Co-Evolution of the Bacterial Pheromone ComS and Sensor ComR Fine-Tunes Natural Transformation in Streptococci.” The Journal of Biological Chemistry, October, 101346. https://doi.org/10.1016/j.jbc.2021.101346.
Rengifo-Gonzalez, Juan Carlos, Krystel El Hage, Marie-Jeanne Clément, Emilie Steiner, Vandana Joshi, Pierrick Craveur, Dominique Durand, David Pastré, and Ahmed Bouhss. 2021. “The Cooperative Binding of TDP-43 to GU-Rich RNA Repeats Antagonizes TDP-43 Aggregation.” ELife 10 (September): e67605. https://doi.org/10.7554/eLife.67605.
Marsin, Stéphanie, Yazid Adam, Claire Cargemel, Jessica Andreani, Sonia Baconnais, Pierre Legrand, Ines Li de la Sierra-Gallay, et al. 2021. “Study of the DnaB:DciA Interplay Reveals Insights into the Primary Mode of Loading of the Bacterial Replicative Helicase.” Nucleic Acids Research 49 (11): 6569–86. https://doi.org/10.1093/nar/gkab463.
Van Tilbeurgh, Matthieu, Katia Lemdani, Anne-Sophie Beignon, Catherine Chapon, Nicolas Tchitchek, Lina Cheraitia, Ernesto Marcos Lopez, et al. 2021. “Predictive Markers of Immunogenicity and Efficacy for Human Vaccines.” Vaccines 9 (6): 579. https://doi.org/10.3390/vaccines9060579.
Voegele, Alexis, Mirko Sadi, Darragh Patrick O’Brien, Pauline Gehan, Dorothée Raoux‐Barbot, Maryline Davi, Sylviane Hoos, et al. 2021. “A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain Is Essential for Invasion of Eukaryotic Cells.” Advanced Science n/a (n/a): 2003630. https://doi.org/https://doi.org/10.1002/advs.202003630.
Kopina, Brett J, Sophia Missoury, Bruno Collinet, Mark G Fulton, Charles Cirio, Herman van Tilbeurgh, and Charles T Lauhon. 2021. “Structure of a Reaction Intermediate Mimic in T6A Biosynthesis Bound in the Active Site of the TsaBD Heterodimer from Escherichia Coli.” Nucleic Acids Research, no. gkab026 (February). https://doi.org/10.1093/nar/gkab026.
Mortaji, Lamya El, Alejandro Tejada-Arranz, Aline Rifflet, Ivo G. Boneca, Gérard Pehau-Arnaudet, J. Pablo Radicella, Stéphanie Marsin, and Hilde De Reuse. 2020. “A Peptide of a Type I Toxin−antitoxin System Induces Helicobacter Pylori Morphological Transformation from Spiral Shape to Coccoids.” Proceedings of the National Academy of Sciences 117 (49): 31398–409. https://doi.org/10.1073/pnas.2016195117.
Chan-Yao-Chong, Maud, Stephanie Marsin, Sophie Quevillon-Cheruel, Dominique Durand, and Tap Ha-Duong. 2020. “Structural Ensemble and Biological Activity of DciA Intrinsically Disordered Region.” Journal of Structural Biology 212 (1): 107573. https://doi.org/10.1016/j.jsb.2020.107573.
Li de la Sierra-Gallay, Ines, Mathilde Belnou, Beatrice Chambraud, Melanie Genet, Herman van Tilbeurgh, Magali Aumont-Nicaise, Michel Desmadril, Etienne-Emile Baulieu, Yves Jacquot, and Cillian Byrne. 2020. “Bioinspired Hybrid Fluorescent Ligands for the FK1 Domain of FKBP52.” Journal of Medicinal Chemistry 63 (18): 10330–38. https://doi.org/10.1021/acs.jmedchem.0c00825.
Dietrich, Christiane, Ines Li de la Sierra-Gallay, Muriel Masi, Eric Girard, Nathalie Dautin, Florence Constantinesco-Becker, Maryelle Tropis, Mamadou Daffé, Herman van Tilbeurgh, and Nicolas Bayan. 2020. “The C-Terminal Domain of Corynebacterium Glutamicum Mycoloyltransferase A Is Composed of Five Repeated Motifs Involved in Cell Wall Binding and Stability.” Molecular Microbiology 114 (1): 1–16. https://doi.org/10.1111/mmi.14492.
Ahmad, Lama, Stéphane Plancqueel, Noureddine Lazar, Hafsa Korri-Youssoufi, Inès Li de la Sierra-Gallay, Herman van Tilbeurgh, and Laurent Salmon. 2020. “Novel N-Substituted 5-Phosphate-d-Arabinonamide Derivatives as Strong Inhibitors of Phosphoglucose Isomerases: Synthesis, Structure-Activity Relationship and Crystallographic Studies.” Bioorganic Chemistry 102 (June): 104048. https://doi.org/10.1016/j.bioorg.2020.104048.
Ledesma-Garcia, Laura, Jordhan Thuillier, Armando Guzman-Espinola, Imke Ensinck, Inès Li de la Sierra-Gallay, Noureddine Lazar, Magali Aumont-Nicaise, et al. 2020. “Molecular Dissection of Pheromone Selectivity in the Competence Signaling System ComRS of Streptococci.” Proceedings of the National Academy of Sciences of the United States of America 117 (14): 7745–54. https://doi.org/10.1073/pnas.1916085117.
O’Brien, Darragh P., Alexis Voegele, Dorothee Raoux-Barbot, Marilyne Davi, Sara Cannella, Thibaut Douche, Mariette Matondo, et al. 2020. “Disorder-To-Order Transitions and Post-Translational Acylation Control the Folding and Activity of the Bordetella Pertussis CyaA Toxin.” Biophysical Journal 118 (3): 197A-197A.
Ithurbide, Solenne, Geneviève Coste, Johnny Lisboa, Nicolas Eugénie, Esma Bentchikou, Claire Bouthier de la Tour, Dominique Liger, et al. 2020. “Natural Transformation in Deinococcus Radiodurans: A Genetic Analysis Reveals the Major Roles of DprA, DdrB, RecA, RecF, and RecO Proteins.” Frontiers in Microbiology 11: 1253. https://doi.org/10.3389/fmicb.2020.01253.
Berny, Clément, Raphael Le Fèvre, François Guyot, Karine Blondeau, Christine Guizonne, Emilie Rousseau, Nicolas Bayan, and Edouard Alphandéry. 2020. “A Method for Producing Highly Pure Magnetosomes in Large Quantity for Medical Applications Using Magnetospirillum Gryphiswaldense MSR-1 Magnetotactic Bacteria Amplified in Minimal Growth Media.” Frontiers in Bioengineering and Biotechnology 8: 16. https://doi.org/10.3389/fbioe.2020.00016.
Damke, Prashant P., Anne Marie Di Guilmi, Paloma Fernández Varela, Christophe Velours, Stéphanie Marsin, Xavier Veaute, Mérick Machouri, et al. 2019. “Identification of the Periplasmic DNA Receptor for Natural Transformation of Helicobacter Pylori.” Nature Communications 10 (1): 5357. https://doi.org/10.1038/s41467-019-13352-6.
Chan-Yao-Chong, Maud, Dominique Durand, and Tâp Ha-Duong. 2019. “Investigation into Early Steps of Actin Recognition by the Intrinsically Disordered N-WASP Domain V.” International Journal of Molecular Sciences 20 (18): 4493. https://doi.org/10.3390/ijms20184493.
Arrondel, Christelle, Sophia Missoury, Rozemarijn Snoek, Julie Patat, Giulia Menara, Bruno Collinet, Dominique Liger, et al. 2019. “Defects in T6A TRNA Modification Due to GON7 and YRDC Mutations Lead to Galloway-Mowat Syndrome.” Nature Communications 10 (1): 3967. https://doi.org/10.1038/s41467-019-11951-x.
Mignolet, Johann, Guillaume Cerckel, Julien Damoczi, Laura Ledesma-Garcia, Andrea Sass, Tom Coenye, Sylvie Nessler, and Pascal Hols. 2019. “Subtle Selectivity in a Pheromone Sensor Triumvirate Desynchronizes Competence and Predation in a Human Gut Commensal.” ELife 8 (August): e47139. https://doi.org/10.7554/eLife.47139.
Missoury, Sophia, Stéphane Plancqueel, Ines Li de la Sierra-Gallay, Wenhua Zhang, Dominique Liger, Dominique Durand, Raoudha Dammak, Bruno Collinet, and Herman van Tilbeurgh. 2019. “The Structure of the TsaB/TsaD/TsaE Complex Reveals an Unexpected Mechanism for the Bacterial T6A TRNA-Modification.” Nucleic Acids Research 47 (17): 9464–65. https://doi.org/10.1093/nar/gkz719.
Meyer, Melanie, Helene Walbott, Vincent Olieric, Jiro Kondo, Maria Costa, and Benoit Masquida. 2019. “Conformational Adaptation of UNCG Loops upon Crowding.” RNA (New York, N.Y.) 25 (11): 1522–31. https://doi.org/10.1261/rna.072694.119.
Pinet, L., Y. Wang, E. Lescop, F. Guerlesquin, D. Durand, N. Assrir, and C. Van Heijenoort. 2019. “Structure and Dynamics of the Intrinsically Disordered C-Terminal Tail of ErbB2, Phosphorylation and Interaction.” European Biophysics Journal with Biophysics Letters 48 (July): S142–S142.
Lisboa, Johnny, Louisa Celmal, Dyana Sanchez, Mathilde Marquis, Jessica Andreani, Raphael Guerois, Francoise Ochsenbein, et al. 2019. “The C-Terminal Domain of HpDprA Is a DNA-Binding Winged Helix Domain That Does Not Bind Double-Stranded DNA.” Febs Journal 286 (10): 1941–58. https://doi.org/10.1111/febs.14788.
Chan-Yao-Chong, Maud, Dominique Durand, and Tâp Ha-Duong. 2019. “Molecular Dynamics Simulations Combined with Nuclear Magnetic Resonance and/or Small-Angle X-Ray Scattering Data for Characterizing Intrinsically Disordered Protein Conformational Ensembles.” Journal of Chemical Information and Modeling 59 (5): 1743–58. https://doi.org/10.1021/acs.jcim.8b00928.
Kretov, Dmitry A., Marie-Jeanne Clement, Guillaume Lambert, Dominique Durand, Dmitry N. Lyabin, Guillaume Bollot, Cyril Bauvais, et al. 2019. “YB-1, an Abundant Core MRNA-Binding Protein, Has the Capacity to Form an RNA Nucleoprotein Filament: A Structural Analysis.” Nucleic Acids Research 47 (6): 3127–41. https://doi.org/10.1093/nar/gky1303.
Chan-Yao-Chong, Maud, Celia Deville, Louise Pinet, Carine van Heijenoort, Dominique Durand, and Tap Ha-Duong. 2019. “Structural Characterization of N-WASP Domain V Using MD Simulations with NMR and SAXS Data.” Biophysical Journal 116 (7): 1216–27. https://doi.org/10.1016/j.bpj.2019.02.015.
Ziegler, Cornelia S., Leila Bouchab, Marc Tramier, Dominique Durand, Franck Fieschi, Sophie Dupre-Crochet, Fabienne Merola, Oliver Nusse, and Marie Erard. 2019. “Quantitative Live-Cell Imaging and 3D Modeling Reveal Critical Functional Features in the Cytosolic Complex of Phagocyte NADPH Oxidase.” Journal of Biological Chemistry 294 (11): 3824–36. https://doi.org/10.1074/jbc.RA118.006864.
Léger, Corentin, Thibault Di Meo, Magali Aumont-Nicaise, Christophe Velours, Dominique Durand, Ines Li de la Sierra-Gallay, Herman van Tilbeurgh, et al. 2019. “Ligand-Induced Conformational Switch in an Artificial Bidomain Protein Scaffold.” Scientific Reports 9 (1): 1178. https://doi.org/10.1038/s41598-018-37256-5.
Shi, Lei, Andrea Cavagnino, Jean-Luc Rabefiraisana, Noureddine Lazar, Inès Li de la Sierra-Gallay, Françoise Ochsenbein, Marie Valerio-Lepiniec, et al. 2019. “Structural Analysis of the Hanks-Type Protein Kinase YabT From Bacillus Subtilis Provides New Insights in Its DNA-Dependent Activation.” Frontiers in Microbiology 9: 3014. https://doi.org/10.3389/fmicb.2018.03014.
Hardouin, Pierre, Christophe Velours, Charles Bou-Nader, Nadine Assrir, Soumaya Laalami, Harald Putzer, Dominique Durand, and Beatrice Golinelli-Pimpaneau. 2018. “Dissociation of the Dimer of the Intrinsically Disordered Domain of RNase Y upon Antibody Binding.” Biophysical Journal 115 (11): 2102–13. https://doi.org/10.1016/j.bpj.2018.10.016.
Voegele, Alexis, Darragh P. O’Brien, Orso Subrini, Nicolas Sapay, Sara E. Cannella, Veronique Yvette Ntsogo Enguene, Audrey Hessel, et al. 2018. “Translocation and Calmodulin-Activation of the Adenylate Cyclase Toxin (CyaA) of Bordetella Pertussis.” Pathogens and Disease 76 (8): fty085. https://doi.org/10.1093/femspd/fty085.
Celma, Louisa, Philippe Cuniasse, Dominique Durand, Johnny Lisboa, Dyana Sanchez, Stephanie Marsin, Sophie Quevillon-Cheruel, and Pablo Radicella. 2018. “HpDprA Domains Involved in Interaction with DNA.” Acta Crystallographica A-Foundation and Advances 74 (August): E201–E201. https://doi.org/10.1107/S2053273318092124.
Pichard-Kostuch, Adeline, Wenhua Zhang, Dominique Liger, Marie-Claire Daugeron, Juliette Létoquart, Ines Li de la Sierra-Gallay, Patrick Forterre, Bruno Collinet, Herman van Tilbeurgh, and Tamara Basta. 2018. “Structure-Function Analysis of Sua5 Protein Reveals Novel Functional Motifs Required for the Biosynthesis of the Universal T6A TRNA Modification.” RNA (New York, N.Y.) 24 (7): 926–38. https://doi.org/10.1261/rna.066092.118.
Edoo, Zainab, Laura Iannazzo, Fabrice Compain, Inès Li de la Sierra Gallay, Herman van Tilbeurgh, Matthieu Fonvielle, Flavie Bouchet, et al. 2018. “Synthesis of Avibactam Derivatives and Activity on β-Lactamases and Peptidoglycan Biosynthesis Enzymes of Mycobacteria.” Chemistry (Weinheim an Der Bergstrasse, Germany) 24 (32): 8081–86. https://doi.org/10.1002/chem.201800923.
Missoury, Sophia, Stéphane Plancqueel, Ines Li de la Sierra-Gallay, Wenhua Zhang, Dominique Liger, Dominique Durand, Raoudha Dammak, Bruno Collinet, and Herman van Tilbeurgh. 2018. “The Structure of the TsaB/TsaD/TsaE Complex Reveals an Unexpected Mechanism for the Bacterial T6A TRNA-Modification.” Nucleic Acids Research 46 (11): 5850–60. https://doi.org/10.1093/nar/gky323.
Ahmad, Lama, Stéphane Plancqueel, Virginie Dubosclard, Noureddine Lazar, Wadih Ghattas, Inès Li de la Sierra-Gallay, Herman van Tilbeurgh, and Laurent Salmon. 2018. “Crystal Structure of Phosphomannose Isomerase from Candida Albicans Complexed with 5-Phospho-d-Arabinonhydrazide.” FEBS Letters 592 (10): 1667–80. https://doi.org/10.1002/1873-3468.13059.
Chevrel, Anne, Agnes Mesneau, Dyana Sanchez, Louisa Celma, Sophie Quevillon-Cheruel, Andrea Cavagnino, Sylvie Nessler, et al. 2018. “Alpha Repeat Proteins (ΑRep) as Expression and Crystallization Helpers.” Journal of Structural Biology 201 (2): 88–99. https://doi.org/10.1016/j.jsb.2017.08.002.
O’Brien, Darragh P., Ana Cristina Sotomayor Perez, Johanna Karst, Sara E. Cannella, Véronique Yvette Ntsogo Enguéné, Audrey Hessel, Dorothée Raoux-Barbot, et al. 2018. “Calcium-Dependent Disorder-to-Order Transitions Are Central to the Secretion and Folding of the CyaA Toxin of Bordetella Pertussis, the Causative Agent of Whooping Cough.” Toxicon: Official Journal of the International Society on Toxinology, Toxins: Immunity, Inflammation and Pain, 149 (January): 37–44. https://doi.org/10.1016/j.toxicon.2018.01.007.
O’Brien, Darragh P., Sébastien Brier, Daniel Ladant, Dominique Durand, Alexandre Chenal, and Patrice Vachette. 2018. “SEC-SAXS and HDX-MS: A Powerful Combination. The Case of the Calcium-Binding Domain of a Bacterial Toxin.” Biotechnology and Applied Biochemistry 65 (1): 62–68. https://doi.org/10.1002/bab.1577.
O’Brien, Darragh P., Dominique Durand, Alexis Voegele, Véronique Hourdel, Marilyne Davi, Julia Chamot-Rooke, Patrice Vachette, Sébastien Brier, Daniel Ladant, and Alexandre Chenal. 2017. “Calmodulin Fishing with a Structurally Disordered Bait Triggers CyaA Catalysis.” PLoS Biology 15 (12): e2004486. https://doi.org/10.1371/journal.pbio.2004486.
Celma, Louisa, Christopher Corbinais, Julien Vercruyssen, Xavier Veaute, Inès Li de la Sierra-Gallay, Raphaël Guérois, Didier Busso, et al. 2017. “Structural Basis for the Substrate Selectivity of Helicobacter Pylori NucT Nuclease Activity.” Edited by Concepción Gonzalez-Bello. PLOS ONE 12 (12): e0189049. https://doi.org/10.1371/journal.pone.0189049.
Braun, Daniela A., Jia Rao, Geraldine Mollet, David Schapiro, Marie-Claire Daugeron, Weizhen Tan, Olivier Gribouval, et al. 2017. “Mutations in KEOPS-Complex Genes Cause Nephrotic Syndrome with Primary Microcephaly.” Nature Genetics 49 (10): 1529–38. https://doi.org/10.1038/ng.3933.
Ma, Miao, Ines Li de La Sierra Gallay, Noureddine Lazar, Olivier Pellegrini, Jean Lepault, Ciarán Condon, Dominique Durand, and Herman van Tilbeurgh. 2017. “Trz1, the Long Form RNase Z from Yeast, Forms a Stable Heterohexamer with Endonuclease Nuc1 and Mutarotase.” The Biochemical Journal 474 (21): 3599–3613. https://doi.org/10.1042/BCJ20170435.
Trewhella, Jill, Anthony P. Duff, Dominique Durand, Frank Gabel, J. Mitchell Guss, Wayne A. Hendrickson, Greg L. Hura, et al. 2017. “2017 Publication Guidelines for Structural Modelling of Small-Angle Scattering Data from Biomolecules in Solution: An Update.” Acta Crystallographica. Section D, Structural Biology 73 (Pt 9): 710–28. https://doi.org/10.1107/S2059798317011597.
Fetler, L., and P. Vachette. 2017. “The Quaternary Structure of the R-State of Escherichia Coli Aspartate Transcarbamoylase in Solution Is Different from That in the Crystal and Is Modified by Mg2+·ATP Binding.” Biochemistry 56 (22): 2860–62. https://doi.org/10.1021/acs.biochem.7b00160.
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