Protein homeostasis in development and aging
We study the mechanisms that govern protein homeostasis in developmental processes and during aging using the powerful C. elegans model system
Our group is interested in protein homeostasis, or proteostasis, which corresponds to the capacity of cells and organisms to maintain the integrity of their proteome. Loss of proteostasis during aging is a major driver of cellular dysfunction, and many age-related diseases are characterized by pathological protein misfolding and aggregation. While the machineries that establish and maintain proteostasis are present in all cells, the rate of cellular aging and the phenotypes associated can greatly vary between cell types. Our research aims at understanding how proteostasis is orchestrated in different cell types in an animal.
team
Group Leader Researcher
Researcher
Engineer
PhD student
Lab life...
External funding
ATIP-Avenir
(2023-2026)
Latest publications
2024
Sala AJ, Grant RA, Imran G, Morton C, Brielmann RM, Gorgoń S, Watts J, Bott LC, Morimoto RI. 2024. “Nuclear receptor signaling via NHR-49/MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cues.” Genes & Development https://doi.org/10.1101/gad.351829.124
2023
Sala AJ, Grant RA, Imran G, Morton C, Brielmann RM, Bott LC, Watts J, Morimoto RI. 2023. “Nuclear receptor signaling via NHR-49/MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cues” bioRxiv https://doi.org/10.1101/2023.04.25.537803
2021
Sala, A. J., and R. I. Morimoto. 2021. “Protecting the Future: Balancing Proteostasis for Reproduction.” Trends in Cell Biology https://doi.org/10.1016/j.tcb.2021.09.009
Bott, L. C., M. Forouhan, M. Lieto, A. J. Sala, R. Ellerington, J. O. Johnson, A. A. Speciale, et al. 2021. “Variants in Atp6v0a1 Cause Progressive Myoclonus Epilepsy and Developmental and Epileptic Encephalopathy.” Brain Communication https://doi.org/10.1093/braincomms/fcab245
2020
Sala, A. J., L. C. Bott, R. M. Brielmann, and R. I. Morimoto. 2020. “Embryo Integrity Regulates Maternal Proteostasis and Stress Resilience.” Genes & Development https://doi.org/10.1101/gad.335422.119
2017
Sala, A. J., L. C. Bott, and R. I. Morimoto. 2017. “Shaping Proteostasis at the Cellular, Tissue, and Organismal Level.” Journal of Cell Biology https://doi.org/10.1083/jcb.201612111