We study the mechanisms that govern protein homeostasis in developmental processes and during aging using the powerful C. elegans model system
Our group is interested in protein homeostasis, or proteostasis, which corresponds to the capacity of cells and organisms to maintain the integrity of their proteome. Loss of proteostasis during aging is a major driver of cellular dysfunction, and many age-related diseases are characterized by pathological protein misfolding and aggregation. While the machineries that establish and maintain proteostasis are present in all cells, the rate of cellular aging and the phenotypes associated can greatly vary between cell types. Our research aims at understanding how proteostasis is orchestrated in different cell types in an animal.
team
Ambre SALA
Group Leader
Researcher CNRS
Szymon GORGON
Post Doc
Ioanna STEFANI
PhD student
Matthieu JASSOUD
M2 Student
Lucas VILLEMAINE
L2 intern
Albert BARKIM
M1 intern
External funding
ATIP-Avenir (2023-2026)
Latest publications
2023
Sala AJ, Grant RA, Imran G, Morton C, Brielmann RM, Bott LC, Watts J, Morimoto RI. “Nuclear receptor signaling via NHR-49/MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cues” (April 2023) bioRxiv doi 10.1101/2023.04.25.537803