Protein homeostasis in development and aging

We study the mechanisms that govern protein homeostasis in developmental processes and during aging using the powerful C. elegans model system

Our group is interested in protein homeostasis, or proteostasis, which corresponds to the capacity of cells and organisms to maintain the integrity of their proteome. Loss of proteostasis during aging is a major driver of cellular dysfunction, and many age-related diseases are characterized by pathological protein misfolding and aggregation. While the machineries that establish and maintain proteostasis are present in all cells, the rate of cellular aging and the phenotypes associated can greatly vary between cell types. Our research aims at understanding how proteostasis is orchestrated in different cell types in an animal.

team

SALA Ambre

Group Leader Researcher

GORGON Szymon

Researcher

PIRON PRUNIER Florence

Engineer

ROLLAND Emilie

Master Student

SELLAOUI Rymaz

Master Student

STEFANI Ioanna

PhD student

Lab life...

Celebrating our new paper, new students, and the summer

(finally, maybe?)

Vermidi conference in Lyon, 2024

Ioanna receiving her 1^st place poster prize, Congrats!

2024 Art Show of Cell Biology dpt

Matthieu won 3^rd place with this beautiful painting of our favorite model system. Congrats!

The lab was delighted to host researcher Ola Billing from Umeå University for a short visit this spring.

The lab celebrating Ambre’s HDR defense

External funding

ATIP-Avenir
(2023-2027)

SUFATOP
(2024-2028)

Latest publications

2024

Sala AJ, Grant RA, Imran G, Morton C, Brielmann RM, Gorgoń S, Watts J, Bott LC, Morimoto RI. 2024. “Nuclear receptor signaling via NHR-49/MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cues.” Genes & Development https://doi.org/10.1101/gad.351829.124

2023

Sala AJ, Grant RA, Imran G, Morton C, Brielmann RM, Bott LC, Watts J, Morimoto RI. 2023. “Nuclear receptor signaling via NHR-49/MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cues” bioRxiv https://doi.org/10.1101/2023.04.25.537803

2021

Sala, A. J., and R. I. Morimoto. 2021. “Protecting the Future: Balancing Proteostasis for Reproduction.” Trends in Cell Biology https://doi.org/10.1016/j.tcb.2021.09.009

Bott, L. C., M. Forouhan, M. Lieto, A. J. Sala, R. Ellerington, J. O. Johnson, A. A. Speciale, et al. 2021. “Variants in Atp6v0a1 Cause Progressive Myoclonus Epilepsy and Developmental and Epileptic Encephalopathy.” Brain Communication https://doi.org/10.1093/braincomms/fcab245

2020

Sala, A. J., L. C. Bott, R. M. Brielmann, and R. I. Morimoto. 2020. “Embryo Integrity Regulates Maternal Proteostasis and Stress Resilience.” Genes & Development https://doi.org/10.1101/gad.335422.119

2017

Sala, A. J., L. C. Bott, and R. I. Morimoto. 2017. “Shaping Proteostasis at the Cellular, Tissue, and Organismal Level.” Journal of Cell Biology https://doi.org/10.1083/jcb.201612111