Protein maturation,
cell fate and therapeutics

Publications

Frottin, Frédéric, Manuela Pérez-Berlanga, F. Ulrich Hartl, and Mark S. Hipp. 2021. “Multiple Pathways of Toxicity Induced by C9orf72 Dipeptide Repeat Aggregates and G4C2 RNA in a Cellular Model.” ELife 10 (June): e62718. https://doi.org/10.7554/eLife.62718.
Giglione, Carmela, and Thierry Meinnel. 2021. “Evolution-Driven Versatility of N Terminal Acetylation in Photoautotrophs.” Trends in Plant Science 26 (4): 375–91. https://doi.org/10.1016/j.tplants.2020.11.012.
Meinnel, Thierry, Cyril Dian, and Carmela Giglione. 2020. “Myristoylation, an Ancient Protein Modification Mirroring Eukaryogenesis and Evolution.” Trends in Biochemical Sciences 45 (7): 619–32. https://doi.org/10.1016/j.tibs.2020.03.007.
Bienvenut, Willy V., Annika Brünje, Jean-Baptiste Boyer, Jens S. Mühlenbeck, Gautier Bernal, Ines Lassowskat, Cyril Dian, et al. 2020. “Dual Lysine and N-Terminal Acetyltransferases Reveal the Complexity Underpinning Protein Acetylation.” Molecular Systems Biology 16 (7): e9464. https://doi.org/10.15252/msb.20209464.
Dian, Cyril, Inmaculada Pérez-Dorado, Frédéric Rivière, Thomas Asensio, Pierre Legrand, Markus Ritzefeld, Mengjie Shen, et al. 2020. “High-Resolution Snapshots of Human N-Myristoyltransferase in Action Illuminate a Mechanism Promoting N-Terminal Lys and Gly Myristoylation.” Nature Communications 11 (1): 1132. https://doi.org/10.1038/s41467-020-14847-3.
Huber, Monika, Willy V. Bienvenut, Eric Linster, Iwona Stephan, Laura Armbruster, Carsten Sticht, Dominik Layer, et al. 2020. “NatB-Mediated N-Terminal Acetylation Affects Growth and Biotic Stress Responses.” Plant Physiology 182 (2): 792–806. https://doi.org/10.1104/pp.19.00792.
Linster, Eric, Dominik Layer, Willy V. Bienvenut, Trinh V. Dinh, Felix A. Weyer, Wiebke Leemhuis, Annika Brünje, et al. 2020. “The Arabidopsis Nα-Acetyltransferase NAA60 Locates to the Plasma Membrane and Is Vital for the High Salt Stress Response.” New Phytologist 228 (2): 554–69. https://doi.org/https://doi.org/10.1111/nph.16747.
Armbruster, Laura, Eric Linster, Jean-Baptiste Boyer, Annika Brünje, Jürgen Eirich, Iwona Stephan, Willy V. Bienvenut, et al. 2020. “NAA50 Is an Enzymatically Active Nα-Acetyltransferase That Is Crucial for Development and Regulation of Stress Responses.” Plant Physiology 183 (4): 1502–16. https://doi.org/10.1104/pp.20.00222.
Vetten, H. Josef, Dennis Knierim, Mirko Sebastian Rakoski, Wulf Menzel, Edgar Maiss, Bruno Gronenborn, Stephan Winter, and Bjoern Krenz. 2019. “Identification of a Novel Nanovirus in Parsley.” Archives of Virology 164 (7): 1883–87. https://doi.org/10.1007/s00705-019-04280-3.
Millar, A. Harvey, Joshua L. Heazlewood, Carmela Giglione, Michael J. Holdsworth, Andreas Bachmair, and Waltraud X. Schulze. 2019. “The Scope, Functions, and Dynamics of Posttranslational Protein Modifications.” In Annual Review of Plant Biology, 70:119–51. Annual Reviews. 10.1146/annurev-arplant-050718-100211.
Knierim, Dennis, Quentin Barrière, Ioana Grigoras, Stephan Winter, Heinrich-Josef Vetten, Mark Schwinghamer, John Thomas, Paul Chu, Bruno Gronenborn, and Tatiana Timchenko. 2019. “Subterranean Clover Stunt Virus Revisited: Detection of Two Missing Genome Components.” Viruses 11 (2): 138. https://doi.org/10.3390/v11020138.
Apel, Cecile, Jerome Bignon, Maria Concepcion Garcia-Alvarez, Sarah Ciccone, Patricia Clerc, Isabelle Grondin, Emmanuelle Girard-Valenciennes, et al. 2018. “N-Myristoyltransferases Inhibitory Activity of Ellagitannins from Terminalia Bentzoe (L.) L. f. Subsp. Bentzoe.” Fitoterapia 131 (November): 91–95. https://doi.org/10.1016/j.fitote.2018.10.014.
Castrec, Benoit, Cyril Dian, Sarah Ciccone, Coralie L. Ebert, Willy V. Bienvenut, Jean-Pierre Le Caer, Jean-Marc Steyaert, Carmela Giglione, and Thierry Meinnel. 2018. “Structural and Genomic Decoding of Human and Plant Myristoylomes Reveals a Definitive Recognition Pattern.” Nature Chemical Biology 14 (7): 671–79. https://doi.org/10.1038/s41589-018-0077-5.
Majeran, Wojciech, Jean-Pierre Le Caer, Lalit Ponnala, Thierry Meinnel, and Carmela Giglione. 2018. “Targeted Profiling of Arabidopsis Thaliana Subproteomes Illuminates Co- and Posttranslationally N-Terminal Myristoylated Proteins.” The Plant Cell 30 (3): 543–62. https://doi.org/10.1105/tpc.17.00523.
Grzela, Renata, Julien Nusbaum, Sonia Fieulaine, Francesco Lavecchia, Michel Desmadril, Naima Nhiri, Alain Van Dorsselaer, et al. 2018. “Peptide Deformylases from Vibrio Parahaemolyticus Phage and Bacteria Display Similar Deformylase Activity and Inhibitor Binding Clefts.” Biochimica Et Biophysica Acta 1866 (2): 348–55. https://doi.org/10.1016/j.bbapap.2017.10.007.
Grigoras, Ioana, Heinrich-Josef Vetten, Ulrich Commandeur, Heiko Ziebell, Bruno Gronenborn, and Tatiana Timchenko. 2018. “Nanovirus DNA-N Encodes a Protein Mandatory for Aphid Transmission.” Virology 522: 281–91. https://doi.org/10.1016/j.virol.2018.07.001.
Grzela, Renata, Julien Nusbaum, Sonia Fieulaine, Francesco Lavecchia, Willy V. Bienvenut, Cyril Dian, Thierry Meinnel, and Carmela Giglione. 2017. “The C-Terminal Residue of Phage Vp16 PDF, the Smallest Peptide Deformylase, Acts as an Offset Element Locking the Active Conformation.” Scientific Reports 7 (1): 11041. https://doi.org/10.1038/s41598-017-11329-3.
Bienvenut, Willy Vincent, Jean-Pierre Scarpelli, Johan Dumestier, Thierry Meinnel, and Carmela Giglione. 2017. “EnCOUNTer: A Parsing Tool to Uncover the Mature N-Terminus of Organelle-Targeted Proteins in Complex Samples.” BMC Bioinformatics 18 (1): 182. https://doi.org/10.1186/s12859-017-1595-y.
Fieulaine, Sonia, Rodolphe Alves de Sousa, Laure Maigre, Karim Hamiche, Mickael Alimi, Jean-Michel Bolla, Abbass Taleb, et al. 2017. “Corrigendum: A Unique Peptide Deformylase Platform to Rationally Design and Challenge Novel Active Compounds.” Scientific Reports 7 (January): 39365. https://doi.org/10.1038/srep39365.
Bienvenut, Willy V., Carmela Giglione, and Thierry Meinnel. 2017. “SILProNAQ: A Convenient Approach for Proteome-Wide Analysis of Protein N-Termini and N-Terminal Acetylation Quantitation.” In Protein Terminal Profiling, edited by Oliver Schilling, 1574:17–34. New York, NY: Springer New York. https://doi.org/10.1007/978-1-4939-6850-3_3.
Fieulaine, Sonia, Rodolphe Alves de Sousa, Laure Maigre, Karim Hamiche, Mickael Alimi, Jean-Michel Bolla, Abbass Taleb, et al. 2016. “A Unique Peptide Deformylase Platform to Rationally Design and Challenge Novel Active Compounds.” Scientific Reports 6 (October): 35429. https://doi.org/10.1038/srep35429.
Frottin, Frédéric, Willy V. Bienvenut, Jérôme Bignon, Eric Jacquet, Alvaro Sebastian Vaca Jacome, Alain Van Dorsselaer, Sarah Cianferani, Christine Carapito, Thierry Meinnel, and Carmela Giglione. 2016. “MetAP1 and MetAP2 Drive Cell Selectivity for a Potent Anti-Cancer Agent in Synergy, by Controlling Glutathione Redox State.” Oncotarget 7 (39): 63306–23. https://doi.org/10.18632/oncotarget.11216.
Breiman, Adina, Sonia Fieulaine, Thierry Meinnel, and Carmela Giglione. 2016. “The Intriguing Realm of Protein Biogenesis: Facing the Green Co-Translational Protein Maturation Networks.” Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1864 (5): 531–50. https://doi.org/10.1016/j.bbapap.2015.11.002.
Linster, Eric, Iwona Stephan, Willy V. Bienvenut, Jodi Maple-Grødem, Line M. Myklebust, Monika Huber, Michael Reichelt, et al. 2015. “Downregulation of N-Terminal Acetylation Triggers ABA-Mediated Drought Responses in Arabidopsis.” Nature Communications 6 (July): 7640. https://doi.org/10.1038/ncomms8640.
Dinh, Trinh V., Willy V. Bienvenut, Eric Linster, Anna Feldman-Salit, Vincent A. Jung, Thierry Meinnel, Rüdiger Hell, Carmela Giglione, and Markus Wirtz. 2015. “Molecular Identification and Functional Characterization of the First Nα-Acetyltransferase in Plastids by Global Acetylome Profiling.” Proteomics 15 (14): 2426–35. https://doi.org/10.1002/pmic.201500025.
Bienvenut, Willy V., Carmela Giglione, and Thierry Meinnel. 2015. “Proteome-Wide Analysis of the Amino Terminal Status of Escherichia Coli Proteins at the Steady-State and upon Deformylation Inhibition.” Proteomics 15 (14): 2503–18. https://doi.org/10.1002/pmic.201500027.
Xu, Fang, Yan Huang, Lin Li, Patrick Gannon, Eric Linster, Monika Huber, Paul Kapos, et al. 2015. “Two N-Terminal Acetyltransferases Antagonistically Regulate the Stability of a Nod-like Receptor in Arabidopsis.” The Plant Cell 27 (5): 1547–62. https://doi.org/10.1105/tpc.15.00173.
Kraberger, Simona, Safaa G. Kumari, Abdelmagid A. Hamed, Bruno Gronenborn, John E. Thomas, Murray Sharman, Gordon W. Harkins, Brejnev M. Muhire, Darren P. Martin, and Arvind Varsani. 2015. “Molecular Diversity of Chickpea Chlorotic Dwarf Virus in Sudan: High Rates of Intra-Species Recombination - a Driving Force in the Emergence of New Strains.” Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases 29 (January): 203–15. https://doi.org/10.1016/j.meegid.2014.11.024.
Giglione, Carmela, Sonia Fieulaine, and Thierry Meinnel. 2015. “N-Terminal Protein Modifications: Bringing Back into Play the Ribosome.” Biochimie 114: 134–46. https://doi.org/10.1016/j.biochi.2014.11.008.
Stojko, Johann, Sonia Fieulaine, Stéphanie Petiot-Bécard, Alain Van Dorsselaer, Thierry Meinnel, Carmela Giglione, and Sarah Cianférani. 2015. “Ion Mobility Coupled to Native Mass Spectrometry as a Relevant Tool to Investigate Extremely Small Ligand-Induced Conformational Changes.” Analyst 140 (21): 7234–45. https://doi.org/10.1039/C5AN01311A.
Kapos, Paul, Fang Xu, Thierry Meinnel, Carmela Giglione, and Xin Li. 2015. “N-Terminal Modifications Contribute to Flowering Time and Immune Response Regulations.” Plant Signaling & Behavior 10 (10): e1073874. https://doi.org/10.1080/15592324.2015.1073874.
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