Nuclear enveloppe,
Telomeres and DNA repair

Zainu, Akbar, Pauline Dupaigne, Soumya Bouchouika, Julien Cau, Julie A. J. Clément, Pauline Auffret, Virginie Ropars, et al. 2024. “FIGNL1-FIRRM Is Essential for Meiotic Recombination and Prevents DNA Damage-Independent RAD51 and DMC1 Loading.” Nature Communications 15 (1): 7015. https://doi.org/10.1038/s41467-024-51458-8.

Reginato, Giordano, Maria Rosaria Dello Stritto, Yanbo Wang, Jingzhou Hao, Raphael Pavani, Michael Schmitz, Swagata Halder, et al. 2024. “HLTF Disrupts Cas9-DNA Post-Cleavage Complexes to Allow DNA Break Processing.” Nature Communications 15 (1): 5789. https://doi.org/10.1038/s41467-024-50080-y.

Miron, Simona, Pierre Legrand, Pauline Dupaigne, Sari E. van Rossum-Fikkert, Dejan Ristic, Atifa Majeed, Roland Kanaar, Sophie Zinn-Justin, and Alex N. Zelensky. 2024. “DMC1 and RAD51 Bind FxxA and FxPP Motifs of BRCA2 via Two Separate Interfaces.” Nucleic Acids Research, June, gkae452. https://doi.org/10.1093/nar/gkae452.

Martucci, Martial, Amandine Moretton, Aleix Tarrés-Solé, Virginie Ropars, Louise Lambert, Patrick Vernet, Maria Solà, Maria Falkenberg, Geraldine Farge, and Siet van den Wildenberg. 2024. “The Mutation R107Q Alters MtSSB SsDNA Compaction Ability and Binding Dynamics.” Nucleic Acids Research, May, gkae354. https://doi.org/10.1093/nar/gkae354.

Bischerour, Julien, Olivier Arnaiz, Coralie Zangarelli, Vinciane Régnier, Florence Iehl, Virginie Ropars, Jean-Baptiste Charbonnier, and Mireille Bétermier. 2024. “Uncoupling Programmed DNA Cleavage and Repair Scrambles the Paramecium Somatic Genome.” Cell Reports 43 (4): 114001. https://doi.org/10.1016/j.celrep.2024.114001.

Gelot, Camille, Marton Tibor Kovacs, Simona Miron, Emilie Mylne, Alexis Haan, Liza Boeffard-Dosierre, Rania Ghouil, et al. 2024. “Publisher Correction: Polθ Is Phosphorylated by PLK1 to Repair Double-Strand Breaks in Mitosis.” Nature, January. https://doi.org/10.1038/s41586-024-07025-8.

Alvaro-Aranda, Lucia, Ambre Petitalot, Yasmina Djeghmoum, Davide Panigada, Jenny Kaur Singh, Åsa Ehlén, Domagoj Vugic, et al. 2023. “The BRCA2 R2645G Variant Increases DNA Binding and Induces Hyper-Recombination.” Nucleic Acids Research, December, gkad1222. https://doi.org/10.1093/nar/gkad1222.

Bellanger, Tiffany, David da Silva Barreira, Frank Wien, Patrice Delarue, Patrick Senet, Aurélie Rieu, Fabrice Neiers, Paloma Fernández Varela, Sophie Combet, and Stéphanie Weidmann. 2023. “Significant Influence of Four Highly Conserved Amino-Acids in Lipochaperon-Active SHsps on the Structure and Functions of the Lo18 Protein.” Scientific Reports 13 (1): 19036. https://doi.org/10.1038/s41598-023-46306-6.

Ghouil, Rania, Simona Miron, Koichi Sato, Dejan Ristic, Sari E. van Rossum-Fikkert, Pierre Legrand, Malika Ouldali, et al. 2023. “BRCA2-HSF2BP Oligomeric Ring Disassembly by BRME1 Promotes Homologous Recombination.” Science Advances 9 (43): eadi7352. https://doi.org/10.1126/sciadv.adi7352.

Kefala Stavridi, Antonia, Amandine Gontier, Vincent Morin, Philippe Frit, Virginie Ropars, Nadia Barboule, Carine Racca, et al. 2023. “Structural and Functional Basis of Inositol Hexaphosphate Stimulation of NHEJ through Stabilization of Ku-XLF Interaction.” Nucleic Acids Research, October, gkad863. https://doi.org/10.1093/nar/gkad863.

Gelot, Camille, Marton Tibor Kovacs, Simona Miron, Emilie Mylne, Alexis Haan, Liza Boeffard-Dosierre, Rania Ghouil, et al. 2023. “Polθ Is Phosphorylated by PLK1 to Repair Double-Strand Breaks in Mitosis.” Nature, September. https://doi.org/10.1038/s41586-023-06506-6.

Perrin, Marie E., Bo Li, Johanne Mbianda, May Bakail, Christophe André, Gwenaëlle Moal, Pierre Legrand, et al. 2023. “Unexpected Binding Modes of Inhibitors to the Histone Chaperone ASF1 Revealed by a Foldamer Scanning Approach.” Chemical Communications (Cambridge, England), June. https://doi.org/10.1039/d3cc01891a.

Seif-El-Dahan, Murielle, Antonia Kefala-Stavridi, Philippe Frit, Steven W. Hardwick, Dima Y. Chirgadze, Taiana Maia De Oliviera, Sébastien Britton, et al. 2023. “PAXX Binding to the NHEJ Machinery Explains Functional Redundancy with XLF.” Science Advances 9 (22): eadg2834. https://doi.org/10.1126/sciadv.adg2834.

Hardwick, Steven W., Antonia Kefala Stavridi, Dimitri Y. Chirgadze, Taiana Maia De Oliveira, Jean-Baptiste Charbonnier, Virginie Ropars, Katheryn Meek, Tom L. Blundell, and Amanda K. Chaplin. 2023. “Cryo-EM Structure of a DNA-PK Trimer: Higher Order Oligomerisation in NHEJ.” Structure (London, England: 1993), May, S0969-2126(23)00167-3. https://doi.org/10.1016/j.str.2023.05.013.

Taouis, Karim, Sophie Vacher, Josée Guirouilh-Barbat, Jacques Camonis, Etienne Formstecher, Tatiana Popova, Anne-Sophie Hamy, et al. 2023. “WWOX Binds MERIT40 and Modulates Its Function in Homologous Recombination, Implications in Breast Cancer.” Cancer Gene Therapy, May. https://doi.org/10.1038/s41417-023-00626-x.

Marcelot, Agathe, Felipe Rodriguez-Tirado, Philippe Cuniasse, Mei-Ling Joiner, Simona Miron, Alexey A. Soshnev, Mimi Fang, et al. 2023. “A De Novo Sequence Variant in Barrier-to-Autointegration Factor Is Associated with Dominant Motor Neuronopathy.” Cells 12 (6): 847. https://doi.org/10.3390/cells12060847.

Audoynaud, Charlotte, Kamila Schirmeisen, Anissia Ait Saada, Armelle Gesnik, Paloma Fernández-Varela, Virginie Boucherit, Virginie Ropars, et al. 2023. “RNA:DNA Hybrids from Okazaki Fragments Contribute to Establish the Ku-Mediated Barrier to Replication-Fork Degradation.” Molecular Cell, February, S1097-2765(23)00106-5. https://doi.org/10.1016/j.molcel.2023.02.008.

Honfozo, Ariane, Rania Ghouil, Tchilabalo Dilezitoko Alayi, Malika Ouldali, Ana-Andreea Arteni, Cynthia Menonve Atindehou, Lucie Ayi Fanou, Yetrib Hathout, Sophie Zinn-Justin, and Stanislas Tomavo. 2023. “The Luminal Domain of Toxoplasma Gondii Sortilin Adopts a Ring-Shaped Structure Exhibiting Motifs Specific to Apicomplexan Parasites.” Frontiers in Parasitology 2. https://www.frontiersin.org/articles/10.3389/fpara.2023.1103772.

Shenoy, Jayakrishna, Alons Lends, Mélanie Berbon, Muhammed Bilal, Nadia El Mammeri, Mathilde Bertoni, Ahmad Saad, et al. 2023. “Structural Polymorphism of the Low-Complexity C-Terminal Domain of TDP-43 Amyloid Aggregates Revealed by Solid-State NMR.” Frontiers in Molecular Biosciences 10:1148302. https://doi.org/10.3389/fmolb.2023.1148302.

Marcelot, Agathe, Sophie Zinn-Justin, and Philippe Cuniasse. 2022. “The Conformation of the Intrinsically Disordered N-Terminal Region of Barrier-to-Autointegration Factor (BAF) Is Regulated by PH and Phosphorylation.” Journal of Molecular Biology, November, 167888. https://doi.org/10.1016/j.jmb.2022.167888.

Theillet, Francois-Xavier, and Enrico Luchinat. 2022. “In-Cell NMR: Why and How?” Progress in Nuclear Magnetic Resonance Spectroscopy 132–133 (October):1–112. https://doi.org/10.1016/j.pnmrs.2022.04.002.

Janssen, Anne, Agathe Marcelot, Sophia Breusegem, Pierre Legrand, Sophie Zinn-Justin, and Delphine Larrieu. 2022. “The BAF A12T Mutation Disrupts Lamin A/C Interaction, Impairing Robust Repair of Nuclear Envelope Ruptures in Nestor–Guillermo Progeria Syndrome Cells.” Nucleic Acids Research, August, gkac726. https://doi.org/10.1093/nar/gkac726.

Cartwright, Tyrell N., Rebecca J. Harris, Stephanie K. Meyer, Aye M. Mon, Nikolaus A. Watson, Cheryl Tan, Agathe Marcelot, et al. 2022. “Dissecting the Roles of Haspin and VRK1 in Histone H3 Phosphorylation during Mitosis.” Scientific Reports 12 (1): 11210. https://doi.org/10.1038/s41598-022-15339-8.

Laroche, Adrien, Maria Lucia Orsini Delgado, Benjamin Chalopin, Philippe Cuniasse, Steven Dubois, Raphaël Sierocki, Fabrice Gallais, et al. 2022. “Deep Mutational Engineering of Broadly-Neutralizing Nanobodies Accommodating SARS-CoV-1 and 2 Antigenic Drift.” MAbs 14 (1): 2076775. https://doi.org/10.1080/19420862.2022.2076775.

Theillet, Francois-Xavier. 2022. “In-Cell Structural Biology by NMR: The Benefits of the Atomic Scale.” Chemical Reviews, March. https://doi.org/10.1021/acs.chemrev.1c00937.

Pieri, Laura, Fengbin Wang, Ana-Andreea Arteni, Matthijn Vos, Jean-Marie Winter, Marie-Hélène Le Du, Franck Artzner, et al. 2022. “Atomic Structure of Lanreotide Nanotubes Revealed by Cryo-EM.” Proceedings of the National Academy of Sciences 119 (4). https://doi.org/10.1073/pnas.2120346119.

Charbonnier, Jean Baptiste. 2022. “Tandem Regulation of MutS Activity by ATP and DNA during MMR Initiation.” Nature Structural & Molecular Biology, January, 1–3. https://doi.org/10.1038/s41594-021-00713-3.

Masella, Michel, Alina Crudu, and Fabien Léonforté. 2021. “Hybrid Polarizable Simulations of a Conventional Hydrophobic Polyelectrolyte. Toward a Theoretical Tool for Green Science Innovation.” The Journal of Chemical Physics 155 (11): 114903. https://doi.org/10.1063/5.0056508.

Roch, Benoit, Vincent Abramowski, Olivier Etienne, Stefania Musilli, Pierre David, Jean-Baptiste Charbonnier, Isabelle Callebaut, François D. Boussin, and Jean-Pierre de Villartay. 2021. “A XRCC4 Mutant Mouse, a Model for Human X4 Syndrome, Reveals Interplays with Xlf, PAXX, and ATM in Lymphoid Development.” ELife 10 (September):e69353. https://doi.org/10.7554/eLife.69353.

Etourneaud, Laure, Angela Moussa, Emilie Rass, Diane Genet, Simon Willaume, Caroline Chabance-Okumura, Paul Wanschoor, et al. 2021. “Lamin B1 Sequesters 53BP1 to Control Its Recruitment to DNA Damage.” Science Advances 7 (35): eabb3799. https://doi.org/10.1126/sciadv.abb3799.

Chaplin, Amanda K., Steven W. Hardwick, Antonia Kefala Stavridi, Christopher J. Buehl, Noah J. Goff, Virginie Ropars, Shikang Liang, et al. 2021. “Cryo-EM of NHEJ Supercomplexes Provides Insights into DNA Repair.” Molecular Cell 81 (16): 3400-3409.e3. https://doi.org/10.1016/j.molcel.2021.07.005.

Porro, Antonio, Mohiuddin Mohiuddin, Christina Zurfluh, Vincent Spegg, Jingqi Dai, Florence Iehl, Virginie Ropars, et al. 2021. “FAN1-MLH1 Interaction Affects Repair of DNA Interstrand Cross-Links and Slipped-CAG/CTG Repeats.” Science Advances 7 (31): eabf7906. https://doi.org/10.1126/sciadv.abf7906.

Ghouil, Rania, Simona Miron, Lieke Koornneef, Jasper Veerman, Maarten W. Paul, Marie-Hélène Le Du, Esther Sleddens-Linkels, et al. 2021. “BRCA2 Binding through a Cryptic Repeated Motif to HSF2BP Oligomers Does Not Impact Meiotic Recombination.” Nature Communications 12 (1): 4605. https://doi.org/10.1038/s41467-021-24871-6.

Julien, Manon, Rania Ghouil, Ambre Petitalot, Sandrine M. Caputo, Aura Carreira, and Sophie Zinn-Justin. 2021. “Intrinsic Disorder and Phosphorylation in BRCA2 Facilitate Tight Regulation of Multiple Conserved Binding Events.” Biomolecules 11 (7): 1060. https://doi.org/10.3390/biom11071060.

Dai, Jingqi, Aurore Sanchez, Céline Adam, Lepakshi Ranjha, Giordano Reginato, Pierre Chervy, Carine Tellier-Lebegue, et al. 2021. “Molecular Basis of the Dual Role of the Mlh1-Mlh3 Endonuclease in MMR and in Meiotic Crossover Formation.” Proceedings of the National Academy of Sciences of the United States of America 118 (23): e2022704118. https://doi.org/10.1073/pnas.2022704118.

Roisné-Hamelin, Florian, Sabrina Pobiega, Kévin Jézéquel, Simona Miron, Jordane Dépagne, Xavier Veaute, Didier Busso, et al. 2021. “Mechanism of MRX Inhibition by Rif2 at Telomeres.” Nature Communications 12 (1): 2763. https://doi.org/10.1038/s41467-021-23035-w.

Velours, Christophe, Magali Aumont-Nicaise, Stephan Uebel, Patrick England, Adrian Velazquez-Campoy, David Stroebel, Guillaume Bec, et al. 2021. “Correction to: Macromolecular Interactions in Vitro, Comparing Classical and Novel Approaches.” European Biophysics Journal 50 (3): 331–331. https://doi.org/10.1007/s00249-021-01540-6.

Müller-Landau, Hanna, and Paloma Fernández Varela. 2021. “Correction to: Standard Operation Procedure for SwitchSENSE DRX Systems.” European Biophysics Journal 50 (3): 401–401. https://doi.org/10.1007/s00249-021-01549-x.

Müller-Landau, Hanna, and Paloma Fernández Varela. 2021. “Standard Operation Procedure for SwitchSENSE DRX Systems.” European Biophysics Journal: EBJ 50 (3–4): 389–400. https://doi.org/10.1007/s00249-021-01519-3.

Velours, Christophe, Magali Aumont-Nicaise, Stephan Uebel, Patrick England, Adrian Velazquez-Campoy, David Stroebel, Guillaume Bec, et al. 2021. “Macromolecular Interactions in Vitro, Comparing Classical and Novel Approaches.” European Biophysics Journal: EBJ 50 (3–4): 313–30. https://doi.org/10.1007/s00249-021-01517-5.

Marcelot, Agathe, Ambre Petitalot, Virginie Ropars, Marie-Hélène Le Du, Camille Samson, Stevens Dubois, Guillaume Hoffmann, et al. 2021. “Di-Phosphorylated BAF Shows Altered Structural Dynamics and Binding to DNA, but Interacts with Its Nuclear Envelope Partners.” Nucleic Acids Research 49 (7): 3841–55. https://doi.org/10.1093/nar/gkab184.

Ehlén, Åsa, Gaetana Sessa, Sophie Zinn-Justin, and Aura Carreira. 2021. “The Phospho-Dependent Role of BRCA2 on the Maintenance of Chromosome Integrity.” Cell Cycle (Georgetown, Tex.) 20 (8): 731–41. https://doi.org/10.1080/15384101.2021.1892994.

Öz, Robin, Jing L. Wang, Raphael Guerois, Gaurav Goyal, Sriram Kk, Virginie Ropars, Rajhans Sharma, et al. 2021. “Dynamics of Ku and Bacterial Non-Homologous End-Joining Characterized Using Single DNA Molecule Analysis.” Nucleic Acids Research, February. https://doi.org/10.1093/nar/gkab083.

Aissaoui, Nesrine, Josephine Lai-Kee-Him, Allan Mills, Nathalie Declerck, Zakia Morichaud, Konstantin Brodolin, Sonia Baconnais, et al. 2021. “Modular Imaging Scaffold for Single-Particle Electron Microscopy.” ACS Nano, February. https://doi.org/10.1021/acsnano.0c05113.

Zahid, Sayma, Murielle Seif El Dahan, Florence Iehl, Paloma Fernandez-Varela, Marie-Helene Le Du, Virginie Ropars, and Jean Baptiste Charbonnier. 2021. “The Multifaceted Roles of Ku70/80.” International Journal of Molecular Sciences 22 (8): 4134. https://doi.org/10.3390/ijms22084134.

Gontier, Amandine, Paloma F. Varela, Clément Nemoz, Virginie Ropars, Magali Aumont-Nicaise, Michel Desmadril, and Jean-Baptiste Charbonnier. 2021. “Measurements of Protein-DNA Complexes Interactions by Isothermal Titration Calorimetry (ITC) and Microscale Thermophoresis (MST).” Methods in Molecular Biology (Clifton, N.J.) 2247:125–43. https://doi.org/10.1007/978-1-0716-1126-5_7.

Rahman, Md Maminur, Mohiuddin Mohiuddin, Islam Shamima Keka, Kousei Yamada, Masataka Tsuda, Hiroyuki Sasanuma, Jessica Andreani, et al. 2020. “Genetic Evidence for the Involvement of Mismatch Repair Proteins, PMS2 and MLH3, in a Late Step of Homologous Recombination.” The Journal of Biological Chemistry 295 (51): 17460–75. https://doi.org/10.1074/jbc.RA120.013521.

Verzini, Silvia, Maliha Shah, Francois-Xavier Theillet, Adam Belsom, Jan Bieschke, Erich E. Wanker, Juri Rappsilber, Andres Binolfi, and Philipp Selenko. 2020. “Megadalton-Sized Dityrosine Aggregates of α-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics.” Journal of Molecular Biology 432 (24): 166689. https://doi.org/10.1016/j.jmb.2020.10.023.

Sanchez, Aurore, Céline Adam, Felix Rauh, Yann Duroc, Lepakshi Ranjha, Bérangère Lombard, Xiaojing Mu, et al. 2020. “Exo1 Recruits Cdc5 Polo Kinase to MutLγ to Ensure Efficient Meiotic Crossover Formation.” Proceedings of the National Academy of Sciences of the United States of America 117 (48): 30577–88. https://doi.org/10.1073/pnas.2013012117.

Cannavo, Elda, Aurore Sanchez, Roopesh Anand, Lepakshi Ranjha, Jannik Hugener, Céline Adam, Ananya Acharya, et al. 2020. “Regulation of the MLH1–MLH3 Endonuclease in Meiosis.” Nature 586 (7830): 618–22. https://doi.org/10.1038/s41586-020-2592-2.