Nuclear enveloppe,
Telomeres and DNA repair


Audoynaud, Charlotte, Kamila Schirmeisen, Anissia Ait Saada, Armelle Gesnik, Paloma Fernández-Varela, Virginie Boucherit, Virginie Ropars, et al. 2023. “RNA:DNA Hybrids from Okazaki Fragments Contribute to Establish the Ku-Mediated Barrier to Replication-Fork Degradation.” Molecular Cell, February, S1097-2765(23)00106-5.
Marcelot, Agathe, Sophie Zinn-Justin, and Philippe Cuniasse. 2022. “The Conformation of the Intrinsically Disordered N-Terminal Region of Barrier-to-Autointegration Factor (BAF) Is Regulated by PH and Phosphorylation.” Journal of Molecular Biology, November, 167888.
Janssen, Anne, Agathe Marcelot, Sophia Breusegem, Pierre Legrand, Sophie Zinn-Justin, and Delphine Larrieu. 2022. “The BAF A12T Mutation Disrupts Lamin A/C Interaction, Impairing Robust Repair of Nuclear Envelope Ruptures in Nestor–Guillermo Progeria Syndrome Cells.” Nucleic Acids Research, August, gkac726.
Cartwright, Tyrell N., Rebecca J. Harris, Stephanie K. Meyer, Aye M. Mon, Nikolaus A. Watson, Cheryl Tan, Agathe Marcelot, et al. 2022. “Dissecting the Roles of Haspin and VRK1 in Histone H3 Phosphorylation during Mitosis.” Scientific Reports 12 (1): 11210.
Laroche, Adrien, Maria Lucia Orsini Delgado, Benjamin Chalopin, Philippe Cuniasse, Steven Dubois, Raphaël Sierocki, Fabrice Gallais, et al. 2022. “Deep Mutational Engineering of Broadly-Neutralizing Nanobodies Accommodating SARS-CoV-1 and 2 Antigenic Drift.” MAbs 14 (1): 2076775.
Theillet, Francois-Xavier. 2022. “In-Cell Structural Biology by NMR: The Benefits of the Atomic Scale.” Chemical Reviews, March.
Pieri, Laura, Fengbin Wang, Ana-Andreea Arteni, Matthijn Vos, Jean-Marie Winter, Marie-Hélène Le Du, Franck Artzner, et al. 2022. “Atomic Structure of Lanreotide Nanotubes Revealed by Cryo-EM.” Proceedings of the National Academy of Sciences 119 (4).
Charbonnier, Jean Baptiste. 2022. “Tandem Regulation of MutS Activity by ATP and DNA during MMR Initiation.” Nature Structural & Molecular Biology, January, 1–3.
Masella, Michel, Alina Crudu, and Fabien Léonforté. 2021. “Hybrid Polarizable Simulations of a Conventional Hydrophobic Polyelectrolyte. Toward a Theoretical Tool for Green Science Innovation.” The Journal of Chemical Physics 155 (11): 114903.
Roch, Benoit, Vincent Abramowski, Olivier Etienne, Stefania Musilli, Pierre David, Jean-Baptiste Charbonnier, Isabelle Callebaut, François D. Boussin, and Jean-Pierre de Villartay. 2021. “A XRCC4 Mutant Mouse, a Model for Human X4 Syndrome, Reveals Interplays with Xlf, PAXX, and ATM in Lymphoid Development.” ELife 10 (September): e69353.
Etourneaud, Laure, Angela Moussa, Emilie Rass, Diane Genet, Simon Willaume, Caroline Chabance-Okumura, Paul Wanschoor, et al. 2021. “Lamin B1 Sequesters 53BP1 to Control Its Recruitment to DNA Damage.” Science Advances 7 (35): eabb3799.
Chaplin, Amanda K., Steven W. Hardwick, Antonia Kefala Stavridi, Christopher J. Buehl, Noah J. Goff, Virginie Ropars, Shikang Liang, et al. 2021. “Cryo-EM of NHEJ Supercomplexes Provides Insights into DNA Repair.” Molecular Cell 81 (16): 3400-3409.e3.
Porro, Antonio, Mohiuddin Mohiuddin, Christina Zurfluh, Vincent Spegg, Jingqi Dai, Florence Iehl, Virginie Ropars, et al. 2021. “FAN1-MLH1 Interaction Affects Repair of DNA Interstrand Cross-Links and Slipped-CAG/CTG Repeats.” Science Advances 7 (31): eabf7906.
Ghouil, Rania, Simona Miron, Lieke Koornneef, Jasper Veerman, Maarten W. Paul, Marie-Hélène Le Du, Esther Sleddens-Linkels, et al. 2021. “BRCA2 Binding through a Cryptic Repeated Motif to HSF2BP Oligomers Does Not Impact Meiotic Recombination.” Nature Communications 12 (1): 4605.
Julien, Manon, Rania Ghouil, Ambre Petitalot, Sandrine M. Caputo, Aura Carreira, and Sophie Zinn-Justin. 2021. “Intrinsic Disorder and Phosphorylation in BRCA2 Facilitate Tight Regulation of Multiple Conserved Binding Events.” Biomolecules 11 (7): 1060.
Dai, Jingqi, Aurore Sanchez, Céline Adam, Lepakshi Ranjha, Giordano Reginato, Pierre Chervy, Carine Tellier-Lebegue, et al. 2021. “Molecular Basis of the Dual Role of the Mlh1-Mlh3 Endonuclease in MMR and in Meiotic Crossover Formation.” Proceedings of the National Academy of Sciences of the United States of America 118 (23): e2022704118.
Roisné-Hamelin, Florian, Sabrina Pobiega, Kévin Jézéquel, Simona Miron, Jordane Dépagne, Xavier Veaute, Didier Busso, et al. 2021. “Mechanism of MRX Inhibition by Rif2 at Telomeres.” Nature Communications 12 (1): 2763.
Marcelot, Agathe, Ambre Petitalot, Virginie Ropars, Marie-Hélène Le Du, Camille Samson, Stevens Dubois, Guillaume Hoffmann, et al. 2021. “Di-Phosphorylated BAF Shows Altered Structural Dynamics and Binding to DNA, but Interacts with Its Nuclear Envelope Partners.” Nucleic Acids Research 49 (7): 3841–55.
Ehlén, Åsa, Gaetana Sessa, Sophie Zinn-Justin, and Aura Carreira. 2021. “The Phospho-Dependent Role of BRCA2 on the Maintenance of Chromosome Integrity.” Cell Cycle (Georgetown, Tex.) 20 (8): 731–41.
Öz, Robin, Jing L. Wang, Raphael Guerois, Gaurav Goyal, Sriram Kk, Virginie Ropars, Rajhans Sharma, et al. 2021. “Dynamics of Ku and Bacterial Non-Homologous End-Joining Characterized Using Single DNA Molecule Analysis.” Nucleic Acids Research, February.
Aissaoui, Nesrine, Josephine Lai-Kee-Him, Allan Mills, Nathalie Declerck, Zakia Morichaud, Konstantin Brodolin, Sonia Baconnais, et al. 2021. “Modular Imaging Scaffold for Single-Particle Electron Microscopy.” ACS Nano, February.
Gontier, Amandine, Paloma F. Varela, Clément Nemoz, Virginie Ropars, Magali Aumont-Nicaise, Michel Desmadril, and Jean-Baptiste Charbonnier. 2021. “Measurements of Protein-DNA Complexes Interactions by Isothermal Titration Calorimetry (ITC) and Microscale Thermophoresis (MST).” Methods in Molecular Biology (Clifton, N.J.) 2247: 125–43.
Rahman, Md Maminur, Mohiuddin Mohiuddin, Islam Shamima Keka, Kousei Yamada, Masataka Tsuda, Hiroyuki Sasanuma, Jessica Andreani, et al. 2020. “Genetic Evidence for the Involvement of Mismatch Repair Proteins, PMS2 and MLH3, in a Late Step of Homologous Recombination.” The Journal of Biological Chemistry 295 (51): 17460–75.
Verzini, Silvia, Maliha Shah, Francois-Xavier Theillet, Adam Belsom, Jan Bieschke, Erich E. Wanker, Juri Rappsilber, Andres Binolfi, and Philipp Selenko. 2020. “Megadalton-Sized Dityrosine Aggregates of α-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics.” Journal of Molecular Biology 432 (24): 166689.
Sanchez, Aurore, Céline Adam, Felix Rauh, Yann Duroc, Lepakshi Ranjha, Bérangère Lombard, Xiaojing Mu, et al. 2020. “Exo1 Recruits Cdc5 Polo Kinase to MutLγ to Ensure Efficient Meiotic Crossover Formation.” Proceedings of the National Academy of Sciences of the United States of America 117 (48): 30577–88.
Cannavo, Elda, Aurore Sanchez, Roopesh Anand, Lepakshi Ranjha, Jannik Hugener, Céline Adam, Ananya Acharya, et al. 2020. “Regulation of the MLH1–MLH3 Endonuclease in Meiosis.” Nature 586 (7830): 618–22.
Bodor, Andrea, Jens D. Haller, Chafiaa Bouguechtouli, Francois-Xavier Theillet, Laszlo Nyitray, and Burkhard Luy. 2020. “Power of Pure Shift H Alpha C Alpha Correlations: A Way to Characterize Biomolecules under Physiological Conditions.” Analytical Chemistry 92 (18): 12423–28.
Aráoz, Rómulo, Paul Barnes, Véronique Séchet, Muriel Delepierre, Sophie Zinn-Justin, Jordi Molgó, Armen Zakarian, Philipp Hess, and Denis Servent. 2020. “Cyclic Imine Toxins Survey in Coastal European Shellfish Samples: Bioaccumulation and Mode of Action of 28-O-Palmitoyl Ester of Pinnatoxin-G. First Report of Portimine-A Bioaccumulation.” Harmful Algae 98 (September): 101887.
Marcelot, Agathe, Howard J. Worman, and Sophie Zinn-Justin. 2020. “Protein Structural and Mechanistic Basis of Progeroid Laminopathies.” The FEBS Journal, August.
Lallemand, François, Sophie Vacher, Leanne de Koning, Ambre Petitalot, Adrien Briaux, Keltouma Driouch, Céline Callens, et al. 2020. “The High Protein Expression of FOXO3, but Not That of FOXO1, Is Associated with Markers of Good Prognosis.” Scientific Reports 10 (1): 6920.
Ehlén, Åsa, Charlotte Martin, Simona Miron, Manon Julien, François-Xavier Theillet, Virginie Ropars, Gaetana Sessa, et al. 2020. “Proper Chromosome Alignment Depends on BRCA2 Phosphorylation by PLK1.” Nature Communications 11 (1): 1819.
Lafosse, Marine, Elise Cartier, Kathleen Solmont, Julie Rivollier, Djamille Azazna, Pierre Thuéry, Yves Boulard, et al. 2020. “Clickable Bambusurils to Access Multivalent Architectures.” Organic Letters 22 (8): 3099–3103.
Lambert, Sarah, Valerie Borde, Jean-Baptiste Charbonnier, Francoise Dantzer, Olivier Espeli, Josee Guirouilh-Barbat, Bertrand Llorente, Gaelle Legube, Marie-Noelle Prioleau, and Pablo Radicella. 2020. “From molecular mechanisms to clinical applications. The essentials of the Replication- Repair-Recombination 2019 Symposium.” Bulletin Du Cancer 107 (2): 283–87.
Acher, Eleonor, Michel Masella, Valerie Vallet, and Florent Real. 2020. “Properties of the Tetravalent Actinide Series in Aqueous Phase from a Microscopic Simulation Self-Consistent Engine.” Physical Chemistry Chemical Physics 22 (4): 2343–50.
Guyot, Anne-Cécile, Charlotte Leuxe, Clémence Disdier, Nassima Oumata, Narciso Costa, Gwenaëlle Le Roux, Paloma Fernandez-Varela, et al. 2020. “A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging Mice and Tau Pathology Treatment.” Scientific Reports 10 (1): 1143.
Julien, Manon, Simona Miron, Aura Carreira, François-Xavier Theillet, and Sophie Zinn-Justin. 2020. “1H, 13C and 15N Backbone Resonance Assignment of the Human BRCA2 N-Terminal Region.” Biomolecular NMR Assignments 14 (1): 79–85.
Zinke, Maximilian, Katrin A. A. Sachowsky, Carl Öster, Sophie Zinn-Justin, Raimond Ravelli, Gunnar F. Schröder, Michael Habeck, and Adam Lange. 2020. “Architecture of the Flexible Tail Tube of Bacteriophage SPP1.” Nature Communications 11 (1): 5759.
Alik, Ania, Chafiaa Bouguechtouli, Manon Julien, Wolfgang Bermel, Rania Ghouil, Sophie Zinn-Justin, and Francois-Xavier Theillet. 2020. “Sensitivity-Enhanced C-13-NMR Spectroscopy for Monitoring Multisite Phosphorylation at Physiological Temperature and PH.” Angewandte Chemie-International Edition 59 (26): 10411–15.
Shenoy, Jayakrishna, Nadia El Mammeri, Antoine Dutour, Melanie Berbon, Ahmad Saad, Alons Lends, Estelle Morvan, et al. 2020. “Structural Dissection of Amyloid Aggregates of TDP-43 and Its C-Terminal Fragments TDP-35 and TDP-16.” Febs Journal 287 (12): 2449–67.
Julien, Manon, Chafiaa Bouguechtouli, Ania Alik, Rania Ghouil, Sophie Zinn-Justin, and François-Xavier Theillet. 2020. “Multiple Site-Specific Phosphorylation of IDPs Monitored by NMR.” Methods in Molecular Biology (Clifton, N.J.) 2141: 793–817.
Damke, Prashant P., Anne Marie Di Guilmi, Paloma Fernández Varela, Christophe Velours, Stéphanie Marsin, Xavier Veaute, Mérick Machouri, et al. 2019. “Identification of the Periplasmic DNA Receptor for Natural Transformation of Helicobacter Pylori.” Nature Communications 10 (1): 5357.
Bakail, May, Albane Gaubert, Jessica Andreani, Gwenaëlle Moal, Guillaume Pinna, Ekaterina Boyarchuk, Marie-Cécile Gaillard, et al. 2019. “Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1.” Cell Chemical Biology 26 (11): 1573-1585.e10.
Houriez, Céline, Florent Réal, Valérie Vallet, Michael Mautner, and Michel Masella. 2019. “Ion Hydration Free Energies and Water Surface Potential in Water Nano Drops: The Cluster Pair Approximation and the Proton Hydration Gibbs Free Energy in Solution.” The Journal of Chemical Physics 151 (17): 174504.
Frit, Philippe, Virginie Ropars, Mauro Modesti, Jean-Baptiste Charbonnier, and Patrick Calsou. 2019. “Plugged into the Ku-DNA Hub: The NHEJ Network.” Progress in Biophysics and Molecular Biology 147 (October): 62–76.
Essawy, Nada, Camille Samson, Ambre Petitalot, Sophie Moog, Anne Bigot, Isaline Herrada, Agathe Marcelot, Ana-Andreea Arteni, Catherine Coirault, and Sophie Zinn-Justin. 2019. “An Emerin LEM-Domain Mutation Impairs Cell Response to Mechanical Stress.” Cells 8 (6): 570.
Roos-Weil, Damien, Camille Decaudin, Marine Armand, Veronique Della-Valle, Mboyba K. Diop, Hussein Ghamlouch, Virginie Ropars, et al. 2019. “A Recurrent Activating Missense Mutation in Waldenstrom Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation.” Cancer Discovery 9 (6): 796–811.
Lisboa, Johnny, Louisa Celmal, Dyana Sanchez, Mathilde Marquis, Jessica Andreani, Raphael Guerois, Francoise Ochsenbein, et al. 2019. “The C-Terminal Domain of HpDprA Is a DNA-Binding Winged Helix Domain That Does Not Bind Double-Stranded DNA.” Febs Journal 286 (10): 1941–58.
Real, Florent, Valerie Vallet, and Michel Masella. 2019. “Improving the Description of Solvent Pairwise Interactions Using Local Solute/Solvent Three-Body Functions. The Case of Halides and Carboxylates in Aqueous Environment.” Journal of Computational Chemistry 40 (11): 1209–18.
Petitalot, Ambre, Elodie Dardillac, Eric Jacquet, Naima Nhiri, Josee Guirouilh-Barbat, Patrick Julien, Isslam Bouazzaoui, et al. 2019. “Combining Homologous Recombination and Phosphopeptide-Binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk.” Molecular Cancer Research 17 (1): 54–69.
Samson, Camille, Ambre Petitalot, Florian Celli, Isaline Herrada, Virginie Ropars, Marie-Helene Le Du, Naima Nhiri, et al. 2018. “Structural Analysis of the Ternary Complex between Lamin A/C, BAF and Emerin Identifies an Interface Disrupted in Autosomal Recessive Progeroid Diseases.” Nucleic Acids Research 46 (19): 10460–73.
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