Proteomics - Gif (SICaPS)


Publications collaboratives de la plateforme



Artemisinin and its derivatives target mitochondrial c-type cytochromes in yeast and human cells.

Laleve A, Panozzo C, Kühl I, Bourand-Plantefol A, Ostojic J, Sissoko A, Tribouillard-Tanvier D, Cornu D, Burg A, Meunier B, Blondel M, Clain J, Bonnefoy N, Duval R, Dujardin G. Biochim Biophys Acta Mol Cell Res. 2020 May;1867(5):118661. doi: 10.1016/j.bbamcr.2020.118661. Epub 2020 Jan 25.



Ubiquinone Biosynthesis over the Entire O2 Range: Characterization of a Conserved O2-Independent Pathway.

Pelosi L, Vo CD, Abby SS, Loiseau L, Rascalou B, Hajj Chehade M, Faivre B, Goussé M, Chenal C, Touati N, Binet L, Cornu D, Fyfe CD, Fontecave M, Barras F, Lombard M, Pierrel F. mBio. 2019 Jul 9;10(4). pii: e01319-19. doi: 10.1128/mBio.01319-19.


Synthesis of a non-natural glucose-2-phosphate ester able to dupe the acc system of agrobacterium fabrum.

Li SZ, Vigouroux A, Ahmar M, El Sahili A, Soulere l, Sago l, Cornu D, Morera S, Gueneau Y. Org biomol chem. 2019 jan 31;17(5):1090-1096. Doi: 10.1039/c8ob03086c.



Ubiquitylation Dynamics of the Clock Cell Proteome and TIMELESS during a Circadian Cycle.

Szabó Á, Papin C, Cornu D, Chélot E, Lipinszki Z, Udvardy A, Redeker V, Mayor U, Rouyer F. Cell Rep. 2018 May 22;23(8):2273-2282. doi: 10.1016/j.celrep.2018.04.064.


Analysis of DNAs associated with coconut foliar decay disease implicates a unique single-stranded DNA virus representing a new taxon. Gronenborn B, Randles JW, Knierim D, Barrière Q, Vetten HJ, Warthmann N, Cornu D, Sileye T, Winter S, Timchenko T. Sci Rep. 2018 Apr 9;8(1):5698. doi: 10.1038/s41598-018-23739-y.


Deciphering the reading of the genetic code by near-cognate tRNA. Blanchet S, Cornu D, Hatin I, Grosjean H, Bertin P, Namy O. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3018-3023. doi: 10.1073/pnas.1715578115. Epub 2018 Mar 5.


Factors influencing readthrough therapy for frequent cystic fibrosis premature termination codons. Pranke I, Bidou L, Martin N, Blanchet S, Hatton A, Karri S, Cornu D, Costes B, Chevalier B, Tondelier D, Girodon E, Coupet M, Edelman A, Fanen P, Namy O, Sermet-Gaudelus I, Hinzpeter A. ERJ Open Res. 2018 Feb 23;4(1). pii: 00080-2017. doi: 10.1183/23120541.00080-2017. eCollection 2018 Jan. Erratum in: ERJ Open Res. 2018 Jul 13;4(3):.


Interplay between Selenium Levels and Replicative Senescence in WI-38 Human Fibroblasts: A Proteomic Approach. Hammad G, Legrain Y, Touat-Hamici Z, Duhieu S, Cornu D, Bulteau AL, Chavatte L. Antioxidants (Basel). 2018 Jan 20;7(1). pii: E19. doi: 10.3390/antiox7010019.



Power of protein/tRNA functional assembly against aberrant aggregation. Bou-Nader C, Pecqueur L, Cornu D, Lombard M, Dezi M, Nicaise M, Velours C, Fontecave M, Hamdane D. Phys Chem Chem Phys. 2017 Oct 25;19(41):28014-28027. doi: 10.1039/c7cp05599d


Enzyme Activation with a Synthetic Catalytic Co-enzyme Intermediate: Nucleotide Methylation by Flavoenzymes. Bou-Nader C, Cornu D, Guerineau V, Fogeron T, Fontecave M, Hamdane D. Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12523-12527. doi: 10.1002/anie.201706219. Epub 2017 Sep 5.


The UbiK protein is an accessory factor necessary for bacterial ubiquinone (UQ) biosynthesis and forms a complex with the UQ biogenesis factor UbiJ.

Loiseau L, Fyfe C, Aussel L, Hajj Chehade M, Hernández SB, Faivre B, Hamdane D, Mellot-Draznieks C, Rascalou B, Pelosi L, Velours C, Cornu D, Lombard M, Casadesús J, Pierrel F, Fontecave M, Barras F. J Biol Chem. 2017 Jul 14;292(28):11937-11950. doi: 10.1074/jbc.M117.789164. Epub 2017 May 30.



Functional interplay between Mediator and TFIIB in preinitiation complex assembly in relation to promoter architecture.

Eychenne T, Novikova E, Barrault MB, Alibert O, Boschiero C, Peixeiro N, Cornu D, Redeker V, Kuras L, Nicolas P, Werner M, Soutourina J.

Genes Dev. 2016 Sep 15;30(18):2119-2132. Epub 2016 Sep 29.


An histidine covalent receptor and butenolide complex mediates strigolactone perception.

de Saint Germain A, Clavé G, Badet-Denisot MA, Pillot JP, Cornu D, Le Caer JP, Burger M, Pelissier F, Retailleau P, Turnbull C, Bonhomme S, Chory J, Rameau C, Boyer FD. Nat Chem Biol. 2016 Oct;12(10):787-794. doi: 10.1038/nchembio.2147. Epub 2016 Aug 1.


A chemical chaperone induces inhomogeneous conformational changes in flexible proteins.

Hamdane D, Velours C, Cornu D, Nicaise M, Lombard M, Fontecave M. Phys Chem Chem Phys. 2016 Jul 27;18(30):20410-21. doi: 10.1039/c6cp03635j.


Identification of protein interfaces within the multi-aminoacyl-tRNA synthetase complex: the case of lysyl-tRNA synthetase and the scaffold protein p38.

Rémion A, Khoder-Agha F, Cornu D, Argentini M, Redeker V, Mirande M. FEBS Open Bio. 2016 May 25;6(7):696-706. doi: 10.1002/2211-5463.12074. eCollection 2016 Jul.


Targeted Delivery of Amoxicillin to C. trachomatis by the Transferrin Iron Acquisition Pathway.

Hai J, Serradji N, Mouton L, Redeker V, Cornu D, El Hage Chahine JM, Verbeke P, Hémadi M. PLoS One. 2016 Feb 26;11(2):e0150031. doi: 10.1371/journal.pone.0150031. eCollection 2016.


SAFER, an Analysis Method of Quantitative Proteomic Data, Reveals New Interactors of the C. elegans Autophagic Protein LGG-1.

Yi Z, Manil-Ségalen M, Sago L, Glatigny A, Redeker V, Legouis R, Mucchielli-Giorgi MH. J Proteome Res. 2016 May 6;15(5):1515-23. doi: 10.1021/acs.jproteome.5b01158. Epub 2016 Apr 6.


Evidence for new C-terminally truncated variants of α- and β-tubulins.

Aillaud C, Bosc C, Saoudi Y, Denarier E, Peris L, Sago L, Taulet N, Cieren A, Tort O, Magiera MM, Janke C, Redeker V, Andrieux A, Moutin MJ. Mol Biol Cell. 2016 Feb 15;27(4):640-53. doi: 10.1091/mbc.E15-03-0137. Epub 2016 Jan 6.



Mediator independently orchestrates multiple steps of preinitiation complex assembly in vivo.

Eyboulet F, Wydau-Dematteis S, Eychenne T, Alibert O, Neil H, Boschiero C, Nevers MC, Volland H, Cornu D, Redeker V, Werner M, Soutourina J. Nucleic Acids Res. 2015 Oct 30;43(19):9214-31. doi: 10.1093/nar/gkv782. Epub 2015 Aug 3.


Flavin-Protein Complexes: Aromatic Stacking Assisted by a Hydrogen Bond.

Hamdane D, Bou-Nader C, Cornu D, Hui-Bon-Hoa G, Fontecave M. Biochemistry. 2015 Jul 21;54(28):4354-64. doi: 10.1021/acs.biochem.5b00501. Epub 2015 Jul 8.


Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols.

Parent A, Elduque X, Cornu D, Belot L, Le Caer JP, Grandas A, Toledano MB, D’Autréaux B. Nat Commun. 2015 Jan 19;6:5686. doi: 10.1038/ncomms6686.





Publications protéomiques des équipes d’adossement



Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs.

Shrivastava AN, Bousset L, Renner M, Redeker V, Savistchenko J, Triller A, Melki R. Biophys J. 2020 Jan 28. pii: S0006-3495(20)30069-2. doi: 10.1016/j.bpj.2020.01.022.


NatB-Mediated N-Terminal Acetylation Affects Growth and Biotic Stress Responses.

Huber MBienvenut WV, Linster E, Stephan IArmbruster LSticht CLayer D, Lapouge K, Meinnel TSinning IGiglione CHell R, Wirtz M. Plant Physiol. 2020 Feb;182(2):792-806. doi: 10.1104/pp.19.00792. Epub 2019 Nov 19.



Clustering of Tau fibrils impairs the synaptic composition of α3-Na+/K+-ATPase and AMPA receptors.

Shrivastava AN, Redeker V, Pieri L, Bousset L, Renner M, Madiona K, Mailhes-Hamon C, Coens A, Buée L, Hantraye P, Triller A, Melki R. EMBO J. 2019 Feb 1;38(3). pii: e99871. doi: 10.15252/embj.201899871. Epub 2019 Jan 10.




Structural and genomic decoding of human and plant myristoylomes reveals a definitive recognition pattern.

Castrec B, Dian C, Ciccone S, Ebert CL, Bienvenut WV, Le Caer JP, Steyaert JM, Giglione C, Meinnel T. Nat Chem Biol. 2018 Jul;14(7):671-679. doi: 10.1038/s41589-018-0077-5. Epub 2018 Jun 11.




The C-terminal residue of phage Vp16 PDF, the smallest peptide deformylase, acts as an offset element locking the active conformation.

Grzela R, Nusbaum J, Fieulaine S, Lavecchia F, Bienvenut WV, Dian C, Meinnel T, Giglione C. Sci Rep. 2017 Sep 8;7(1):11041. doi: 10.1038/s41598-017-11329-3.


EnCOUNTer: a parsing tool to uncover the mature N-terminus of organelle-targeted proteins in complex samples.

Bienvenut WV, Scarpelli JP, Dumestier J, Meinnel T, Giglione C. BMC Bioinformatics. 2017 Mar 20;18(1):182. doi: 10.1186/s12859-017-1595-y.


SILProNAQ: A Convenient Approach for Proteome-Wide Analysis of Protein N-Termini and N-Terminal Acetylation Quantitation.

Bienvenut WV, Giglione C, Meinnel T. Methods Mol Biol. 2017;1574:17-34. doi: 10.1007/978-1-4939-6850-3_3.



Data in support of the identification of neuronal and astrocyte proteins interacting with extracellularly applied oligomeric and fibrillar α-synuclein assemblies by mass spectrometry.

Shrivastava AN, Redeker V, Fritz N, Pieri L, Almeida LG, Spolidoro M, Liebmann T, Bousset L, Renner M, Léna C, Aperia A, Melki R, Triller A. Data Brief. 2016 Feb 12;7:221-8. doi: 10.1016/j.dib.2016.02.018. eCollection 2016 Jun


Cellular response of human neuroblastoma cells to α-synuclein fibrils, the main constituent of Lewy bodies.

Pieri L, Chafey P, Le Gall M, Clary G, Melki R, Redeker V. Biochim Biophys Acta. 2016 Jan;1860(1 Pt A):8-19. doi: 10.1016/j.bbagen.2015.10.007. Epub 2015 Oct 22.


MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state.

Frottin F, Bienvenut WV, Bignon J, Jacquet E, Vaca Jacome AS, Van Dorsselaer A, Cianferani S, Carapito C, Meinnel T, Giglione C.

Oncotarget. 2016 Sep 27;7(39):63306-63323. doi: 10.18632/oncotarget.11216.



α-synuclein assemblies sequester neuronal α3-Na+/K+-ATPase and impair Na+ gradient.

Shrivastava AN, Redeker V, Fritz N, Pieri L, Almeida LG, Spolidoro M, Liebmann T, Bousset L, Renner M, Léna C, Aperia A, Melki R, Triller A.NEMBO J. 2015 Oct 1;34(19):2408-23. doi: 10.15252/embj.201591397. Epub 2015 Aug 31.


The 26S Proteasome Degrades the Soluble but Not the Fibrillar Form of the Yeast Prion Ure2p In Vitro.

Wang K, Redeker V, Madiona K, Melki R, Kabani M.NPLoS One. 2015 Jun 26;10(6):e0131789. doi: 10.1371/journal.pone.0131789. Collection 2015.


A novel bio-orthogonal cross-linker for improved protein/protein interaction analysis.

Nury C, Redeker V, Dautrey S, Romieu A, van der Rest G, Renard PY, Melki R, Chamot-Rooke J.NAnal Chem. 2015 Feb 3;87(3):1853-60. doi: 10.1021/ac503892c. Epub 2015 Jan 12.


Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis.

Linster E, Stephan I, Bienvenut WV, Maple-Grødem J, Myklebust LM, Huber M, Reichelt M, Sticht C, Møller SG, Meinnel T, Arnesen T, Giglione C, Hell R, Wirtz M. Nat Commun. 2015 Jul 17;6:7640. doi: 10.1038/ncomms8640.


Proteome-wide analysis of the amino terminal status of Escherichia coli proteins at the steady-state and upon deformylation inhibition.

Bienvenut WV, Giglione C, Meinnel T.

Proteomics. 2015 Jul;15(14):2503-18. doi: 10.1002/pmic.201500027.


Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis.

Xu F, Huang Y, Li L, Gannon P, Linster E, Huber M, Kapos P, Bienvenut W, Polevoda B, Meinnel T, Hell R, Giglione C, Zhang Y, Wirtz M, Chen S, Li X. Plant Cell. 2015 May;27(5):1547-62. doi: 10.1105/tpc.15.00173. Epub 2015 May 12.


Molecular identification and functional characterization of the first Nα-acetyltransferase in plastids by global acetylome profiling.

Dinh TV, Bienvenut WV, Linster E, Feldman-Salit A, Jung VA, Meinnel T, Hell R, Giglione C, Wirtz M. Proteomics. 2015 Jul;15(14):2426-35. doi: 10.1002/pmic.201500025. Epub 2015 Jun 18.


Scroll to Top