Crystallography

X-ray crystallography is one of the most favored techniques for the determination of the atomic structure of proteins, nucleic acids and other molecules. The crystallography facility can provide service and scientific support to clients for their structural biology projects. Workflow for X-ray protein structure determination consists of crystal, diffraction pattern, electron density maps and protein model.

The platform is equipped with several nano-volume pipetting (including Lipidic cubic phase for membrane proteins) and visualization robots, which allow large-scale screening of crystallization conditions at two temperatures (4°C and 19°C). Additionally, the robots facilitate analysis and automated optimization of crystallization conditions for macromolecules. Services provided by the platform include self-service access to crystallization and visualization robots, provision of ready-to-use crystallization kits, and project delivery encompassing structure determination and analysis, including AlphaFold service and model analysis.

The crystallography platform benefits of the proximity of the Synchrotron Soleil and collaborate with the PROXIMA 2 beamline for the development of in situ collected data. 

It is IBiSA labeled (Biology Health and Agronomy Infrastructures) and has the support of the “French Infrastructure for Integrated Structural Biology” (FRISBI). It is open to the entire scientific community including academia and industry.

The platform belongs to Яéciprocs (Réseau des Chercheurs et Ingénieurs Professionnels de la Cristallographie Structurale)