Transcription regulation
in the malaria parasite

Publications

Santos, Joana M., Chloé Oudinet, Lisa Schöne, Audrey Dauba, and Ahmed Amine Khamlichi. 2019. “Essential Role of the Initial Activation Signal in Isotype Selection upon Deletion of a Transcriptionally Committed Promoter.” Scientific Reports 9 (1): 18543. https://doi.org/10.1038/s41598-019-54929-x.
Santos, Joana M., Fatima-Zohra Braikia, Chloé Oudinet, Audrey Dauba, and Ahmed Amine Khamlichi. 2019. “Two Modes of Cis-Activation of Switch Transcription by the IgH Superenhancer.” Proceedings of the National Academy of Sciences 116 (29): 14708–13. https://doi.org/10.1073/pnas.1902250116.
Oudinet, Chloé, Fatima-Zohra Braikia, Audrey Dauba, Joana M. Santos, and Ahmed Amine Khamlichi. 2019. “Developmental Regulation of DNA Cytosine Methylation at the Immunoglobulin Heavy Chain Constant Locus.” PLOS Genetics 15 (2): e1007930. https://doi.org/10.1371/journal.pgen.1007930.
Santos, Joana M., Fatima-Zohra Braikia, Chloé Oudinet, Dania Haddad, Caroline Conte, Audrey Dauba, and Ahmed Amine Khamlichi. 2018. “Duplication of a Germline Promoter Downstream of the IgH 3′ Regulatory Region Impairs Class Switch Recombination.” Scientific Reports 8 (1): 9164. https://doi.org/10.1038/s41598-018-27448-4.
Santos, Joana Mendonca, Gabrielle Josling, Philipp Ross, Preeti Joshi, Lindsey Orchard, Tracey Campbell, Ariel Schieler, Ileana M. Cristea, and Manuel Llinás. 2017. “Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor.” Cell Host & Microbe 21 (6): 731-741.e10. https://doi.org/10.1016/j.chom.2017.05.006.
Cobbold, Simon A., Joana M. Santos, Alejandro Ochoa, David H. Perlman, and Manuel Llinás. 2016. “Proteome-Wide Analysis Reveals Widespread Lysine Acetylation of Major Protein Complexes in the Malaria Parasite.” Scientific Reports 6 (1): 19722. https://doi.org/10.1038/srep19722.
Mueller, Christina, Natacha Klages, Damien Jacot, Joana M. Santos, Ana Cabrera, Tim W. Gilberger, Jean-François Dubremetz, and Dominique Soldati-Favre. 2013. “The Toxoplasma Protein ARO Mediates the Apical Positioning of Rhoptry Organelles, a Prerequisite for Host Cell Invasion.” Cell Host & Microbe 13 (3): 289–301. https://doi.org/10.1016/j.chom.2013.02.001.
Cabrera, Ana, Susann Herrmann, Dominik Warszta, Joana M. Santos, Arun T. John Peter, Maya Kono, Sandra Debrouver, et al. 2012. “Dissection of Minimal Sequence Requirements for Rhoptry Membrane Targeting in the Malaria Parasite.” Traffic 13 (10): 1335–50. https://doi.org/10.1111/j.1600-0854.2012.01394.x.
Santos, Joana M., David J. P. Ferguson, Michael J. Blackman, and Dominique Soldati-Favre. 2011. “Intramembrane Cleavage of AMA1 Triggers Toxoplasma to Switch from an Invasive to a Replicative Mode.” Science 331 (6016): 473–77. https://doi.org/10.1126/science.1199284.
Sheiner, Lilach, Joana M. Santos, Natacha Klages, Fabiola Parussini, Noelle Jemmely, Nikolas Friedrich, Gary E. Ward, and Dominique Soldati-Favre. 2010. “Toxoplasma Gondii Transmembrane Microneme Proteins and Their Modular Design.” Molecular Microbiology 77 (4): 912–29. https://doi.org/10.1111/j.1365-2958.2010.07255.x.
Friedrich, Nikolas, Joana M. Santos, Yan Liu, Angelina S. Palma, Ester Leon, Savvas Saouros, Makoto Kiso, et al. 2010. “Members of a Novel Protein Family Containing Microneme Adhesive Repeat Domains Act as Sialic Acid-Binding Lectins during Host Cell Invasion by Apicomplexan Parasites *.” Journal of Biological Chemistry 285 (3): 2064–76. https://doi.org/10.1074/jbc.M109.060988.
Kelly, Bridie A., Stuart J. Neil, Áine McKnight, Joana M. Santos, Photini Sinnis, Edward R. Jack, David A. Middleton, and Curtis B. Dobson. 2007. “Apolipoprotein E-Derived Antimicrobial Peptide Analogues with Altered Membrane Affinity and Increased Potency and Breadth of Activity.” The FEBS Journal 274 (17): 4511–25. https://doi.org/10.1111/j.1742-4658.2007.05981.x.
Singh, Suprita, Joana M. Santos, Lindsey M. Orchard, Naomi Yamada, Riëtte van Biljon, Heather J. Painter, Shaun Mahony, and Manuel Llinás. 2021. “The PfAP2-G2 Transcription Factor Is a Critical Regulator of Gametocyte Maturation.” Molecular Microbiology 115 (5): 1005–24. https://doi.org/10.1111/mmi.14676.

Kelly B. A., Neil S. J., McKnight A., Santos J. M., Sinnis P., Jack E. R., Middleton D. A. and Dobson C. B. (2007) Apolipoprotein E-derived anti-microbial peptide analogues with altered membrane affinity and increased potency and breadth of activity. FEBS J 274, 4511-25

 

Friedrich N., Santos J. M., Liu Y., Palma A. S., Leon E., Saouros S., Kiso M., Blackman M. J., Matthews S., Feizi T., Soldati-Favre D. (2009) Members of a novel protein family containing MAR domains act as sialic acid-binding lectins during host cell invasion by apicomplexan parasites. J Biol Chem 285, 2064-76

Santos J. M.*, Sheiner L., Klages N., Jemmely N., Friedrich N., Soldati-Favre D. (2010) Toxoplasma transmembrane microneme proteins and their modular design. Mol Microbiol. 77, 912-29

 

Santos J. M., Ferguson D. J., Blackman M. J., Soldati-Favre D. (2011) Intramembrane cleavage of AMA1 switches Toxoplasma from an invasive to a replicative mode. Science 331, 473-7

 

Cabrera A., Herrmann S., Warszta D., Santos J. M., Peter A. J., Kono M., Debrouver S., Jacobs T., Spielmann T., Ungermann C., Soldati-Favre D., Gilberger T. W. (2012) Dissection of minimal sequence requirements for rhoptry membrane targeting in the malaria parasite. Traffic 13, 1335-50

 

Mueller C., Klages N., Jacot D., Santos J. M., Cabrera A., Gilberger T. W., Dubremetz J. F., Soldati D. (2013) The Toxoplasma Protein ARO Mediates the Apical Positioning of Rhoptry Organelles, a Prerequisite for Host Cell Invasion. Cell Host & Microbe 13, 289-301

 

Cobbold S. A., Santos J. M., Ochoa A., Perlman D. H., Llinás M. (2016) Proteome-wide analysis reveals widespread lysine acetylation regulating major protein complexes and the family of ApiAP2 DNA-binding proteins in the malaria parasite. Sci Rep 6, 19722

 

Santos J. M., Josling G., Ross P., Joshi P., Orchard L, Campbell T., Schieler A., Cristea I. M., Llinás M. (2017) Red Blood Cell Invasion by the Malaria Parasite is Coordinated by the PfAP2-I Transcription Factor. Cell Host & Microbe 21, 731-41

 

Santos J. M., Braikia F-Z., Oudinet C., Dauba A., Conte C., Khamlichi A.A. (2018) Duplication of a germline promoter downstream of the IgH 3’RR enhancer impairs class switch recombination. Sci Rep 8, 9164

 

Oudinet C., Braikia F-Z., Dauba A., Santos J. M., Khamlichi A.A. (2019) Developmental regulation of DNA cytosine methylation at the immunoglobulin heavy chain constant locus. PLOS Genetics 15: e1007930

 

Santos J. M., Braikia F-Z., Oudinet C., Dauba A., Khamlichi A.A. (2019) Two modes of cis-activation of switch transcription by the IgH superenhancer. PNAS 116: 201902250

 

Santos J. M., Schöne L., Oudinet C., Dauba A., Khamlichi A.A. (2019) Essential role of the initial activation signal in isotype selection upon deletion of a transcriptionally committed promoter. Sci Rep 9

Singh S., Santos J. M., Orchard L, Yamada N., van Biljon R., Painter H., Mahony S., Llinás M. (2020) The PfAP2-G2 transcription factor is a critical regulator of gametocyte formation. Mol Micro

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