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Ishigami, Kota, Seonghan Jang, Aoba Yoshioka, et al. 2026. “A Trojan Horse Pathogen Breaking through Partner-Choice Barriers in the Insect Gut.” Proceedings of the National Academy of Sciences of the United States of America 123 (18): e2533244123. https://doi.org/10.1073/pnas.2533244123.
Diallinas, George, and Claudio Scazzocchio. 2026. “A 60-Year Journey with a Fungal Transporter: From Classical Genetics to Functional, Structural, and Evolutionary Insights.” Microbiology and Molecular Biology Reviews: MMBR, April 27, e0036425. https://doi.org/10.1128/mmbr.00364-25.
Julien, Manon, Sophie Zinn-Justin, and Francois-Xavier Theillet. 2026. “Advanced NMR Characterization and Sensitive Detection of Isoaspartate in Proteins.” Analytical Chemistry, ahead of print, April 21. https://doi.org/10.1021/acs.analchem.5c07290.
Arnaiz, Olivier, Frédéric Guérin, Arnaud Couloux, et al. 2026. “The Tiny Germline Chromosomes of Paramecium Aurelia Have an Exceptionally High Recombination Rate and Are Capped by a New Class of Helitrons.” BMC Biology 24 (1): 99. https://doi.org/10.1186/s12915-026-02584-w.
Malesinski, Soazig, André Vidal-Meireles, Eve Giovannetti, et al. 2026. “Acclimation of Photosynthesis to the Environment 1 Acts as a Copper-Binding Superoxide Detoxification Enzyme.” Nature Communications, ahead of print, April 15. https://doi.org/10.1038/s41467-026-71893-z.
Balan, Thomas, Mélanie Bazin-Gélis, Marc Guérineau, et al. 2026. “A Developmental Condensin I Complex Assists the Paramecium PiggyMac Domesticated Transposase during Programmed DNA Elimination.” Nucleic Acids Research 54 (7): gkag351. https://doi.org/10.1093/nar/gkag351.
Agnoli, Kirsty, Anugraha Mathew, Stefano Gualdi, et al. 2026. “Identifying Phenotypic and Genetic Traits for Assessing Pathogenic Potential and Biocontrol Capacity in Burkholderia Sensu Lato Strains.” The ISME Journal, April 10, wrag081. https://doi.org/10.1093/ismejo/wrag081.
Gamet, Antoine, Ismaila Ciss, Arthur Courtois, et al. 2026. “Total Synthesis of Photoswitchable Latrunculin B Enables Reversible Control of Actin Polymerization and Cell Migration.” Journal of the American Chemical Society, ahead of print, April 8. https://doi.org/10.1021/jacs.5c17295.
Corroyer-Dulmont, Simon, Audrey Labarde, Vojtěch Pražák, et al. 2026. “Subcellular Reorganization upon Phage Infection Reveals Stepwise Assembly of Viral Particles from Membrane-Associated Precursors.” Nature Communications, ahead of print, April 2. https://doi.org/10.1038/s41467-026-71181-w.
Moris, Arnaud, Emiliano Ricci, and Olivier Namy. 2026. “[HIV-1 translational inventory reveals about a hundred of alternative ORFs and new antigens].” Medecine Sciences: M/S 42 (4): 346–49. https://doi.org/10.1051/medsci/2026051.