I2BC publishes 150
articles and reviews a year
Latest Publications
3888256
i2bc
1
chicago-author-date
10
date
desc
year
4613
https://www.i2bc.paris-saclay.fr/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22G9BYRPDS%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bo%5Cu00ebffard-Dosierre%20et%20al.%22%2C%22parsedDate%22%3A%222026-12-31%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBo%26%23xEB%3Bffard-Dosierre%2C%20Liza%2C%20Camille%20Dagallier%2C%20G%26%23xE9%3Braldine%20Eudier%2C%20et%20al.%202026.%20%26%23x201C%3BNMR%20Detects%20Clustering%20and%20Ultra-Weak%20Excipient%20Interactions%20Governing%20Monoclonal%20Antibody%20Viscosity%20in%20Formulation-Relevant%20Conditions.%26%23x201D%3B%20%26lt%3Bi%26gt%3BmAbs%26lt%3B%5C%2Fi%26gt%3B%2018%20%281%29%3A%202685366.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F19420862.2026.2685366%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F19420862.2026.2685366%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22NMR%20detects%20clustering%20and%20ultra-weak%20excipient%20interactions%20governing%20monoclonal%20antibody%20viscosity%20in%20formulation-relevant%20conditions%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liza%22%2C%22lastName%22%3A%22Bo%5Cu00ebffard-Dosierre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Camille%22%2C%22lastName%22%3A%22Dagallier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00e9raldine%22%2C%22lastName%22%3A%22Eudier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vasco%22%2C%22lastName%22%3A%22Filipe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Atifa%22%2C%22lastName%22%3A%22Badar-Majeed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sol%5Cu00e8ne%22%2C%22lastName%22%3A%22Fraumont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Zinn-Justin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francois-Xavier%22%2C%22lastName%22%3A%22Theillet%22%7D%5D%2C%22abstractNote%22%3A%22High-concentration%20formulations%20of%20monoclonal%20antibodies%20%28mAbs%29%20are%20required%20for%20subcutaneous%20administration%20but%20are%20frequently%20challenging%20to%20develop%20due%20to%20elevated%20viscosity%20and%20colloidal%20instability.%20These%20properties%20are%20governed%20by%20mAb-mAb%20interactions%20that%20are%20regulated%20by%20additional%20mAb-excipient%20interactions.%20These%20ultra-weak%20interactions%20remain%20difficult%20to%20characterize%20using%20conventional%20techniques.%20Here%2C%20we%20combined%20nuclear%20magnetic%20resonance%20%28NMR%29%20spectroscopy%20with%20rheometry%20and%20dynamic%20light%20scattering%20to%20investigate%20mAb%20interactions%20under%20formulation-relevant%20conditions.%20Rheological%20measurements%20showed%20that%2C%20in%20the%20case%20of%20the%20chosen%20mAb%2C%20the%20excipients%20arginine%20and%20lysine%20strongly%20reduce%20the%20macroscopic%20viscosity%2C%20whereas%20other%20excipients%20display%20a%20moderate%20effect%20by%20themselves.%20Characterization%20of%20the%20mAb%20oligomeric%20state%20by%201H%20NMR%20confirmed%20that%20arginine%20and%20lysine%20are%20the%20most%20efficient%20at%20reducing%20mAb%20self-assembly%2C%20while%20proline%20and%20glycine%20promote%20clustering.%20Interactions%20between%20mAb%20and%20excipients%20were%20first%20analyzed%20by%20measuring%20excipient%20diffusion%20coefficients%2C%20but%20these%20are%20only%20weakly%20affected%20by%20the%20addition%20of%20concentrated%20mAb.%20The%20mAb-excipient%20interactions%20were%20further%20detected%20by%20measuring%20excipient%201H%20and%2013C%20chemical%20shifts%2C%20mAb-excipient%20saturation%20transfers%2C%20and%20excipient%201H%20transverse%20relaxation%20rates.%20These%20experiments%20provided%20complementary%20information%20on%20excipient%20interactions%20with%20the%20different%20mAb%20oligomers.%20Lysine%20was%20identified%20as%20the%20best%20mAb%20binder.%20However%2C%20several%20excipients%20such%20as%20sucrose%20that%20do%20not%20reduce%20the%20macroscopic%20viscosity%20also%20bind%20to%20concentrated%20mAb%2C%20highlighting%20that%20excipient%20binding%20can%20have%20various%20consequences%20on%20the%20transient%20interactions%20between%20mAb%20species.%20Altogether%2C%20this%20work%20proposes%20a%20powerful%20NMR%20pipeline%20to%20dissect%20ultra-weak%20molecular%20interactions%20that%20govern%20viscosity%20and%20developability%20in%20therapeutic%20antibody%20formulations.%22%2C%22date%22%3A%222026-12-31%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1080%5C%2F19420862.2026.2685366%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%2242272436%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221942-0870%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-06-12T07%3A26%3A39Z%22%7D%7D%2C%7B%22key%22%3A%2247CHKPME%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Toukabri%20et%20al.%22%2C%22parsedDate%22%3A%222026-12%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BToukabri%2C%20Hasna%2C%20Christophe%20Buisson%2C%20Yves%20Le%20Vern%2C%20Alix%20Sausset%2C%20Micka%26%23xEB%3Bl%20Bourge%2C%20and%20Leyla%20Slamti.%202026.%20%26%23x201C%3BFACS-Based%20Isolation%20and%20Recovery%20of%20Physiologically%20Distinct%20Bacterial%20Subpopulations%20from%20Infected%20Insect%20Hosts.%26%23x201D%3B%20%26lt%3Bi%26gt%3BMethodsX%26lt%3B%5C%2Fi%26gt%3B%2017%20%28December%29%3A%20104194.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.mex.2026.104194%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.mex.2026.104194%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22FACS-based%20isolation%20and%20recovery%20of%20physiologically%20distinct%20bacterial%20subpopulations%20from%20infected%20insect%20hosts%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hasna%22%2C%22lastName%22%3A%22Toukabri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Buisson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yves%20Le%22%2C%22lastName%22%3A%22Vern%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alix%22%2C%22lastName%22%3A%22Sausset%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Micka%5Cu00ebl%22%2C%22lastName%22%3A%22Bourge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leyla%22%2C%22lastName%22%3A%22Slamti%22%7D%5D%2C%22abstractNote%22%3A%22Phenotypic%20heterogeneity%20is%20often%20encountered%20during%20infection%20but%20remains%20challenging%20to%20investigate%20in%20vivo.%20Here%2C%20using%20the%20entomopathogenic%20spore-former%20Bacillus%20thuringiensis%20with%20the%20Galleria%20mellonella%20insect%20larva%20infection%20model%20and%20Fluorescence-Activated%20Cell%20Sorting%20%28FACS%29%2C%20we%20present%20a%20workflow%20that%20enables%20the%20isolation%20of%20bacterial%20subpopulations%20in%20distinct%20physiological%20states%2C%20directly%20from%20infected%20hosts%2C%20for%20downstream%20characterization.%20Host-derived%20debris%20and%20the%20low%20bacterial%20recovery%20after%20sorting%20represent%20major%20limitations%20of%20in%20vivo-derived%20FACS%20approaches.%20By%20combining%20pre-sorting%20filtration%2C%20optimized%20FACS%20parameters%2C%20and%20post-sorting%20processing%2C%20the%20workflow%20minimizes%20host-derived%20contamination%20while%20preserving%20bacterial%20viability%20and%20physiological%20integrity.%20The%20recovered%20subpopulations%20are%20suitable%20for%20a%20wide%20range%20of%20downstream%20characterization%2C%20including%20reinfection%20experiments%2C%20tolerance%20assays%2C%20infection%20cycle%20studies%20and%20competition%20assays.%20As%20an%20illustrative%20application%2C%20we%20used%20this%20method%20on%20larvae%20infected%20with%20a%20strain%20harboring%20a%20fluorescent%20reporter%20that%20marks%20cells%20irreversibly%20committed%20to%20sporulation.%20Sporulating%20and%20non-sporulating%20bacteria%20recovered%20from%20the%20insects%20were%20successfully%20separated%20and%20subsequently%20used%20in%20reinfection%20experiments.%20%5Cu2022%20Isolation%20of%20physiologically%20distinct%20bacterial%20subpopulations%20directly%20from%20infected%20insect%20hosts%20%5Cu2022%20FACS-based%20separation%20of%20bacterial%20subpopulations%20using%20fluorescent%20reporters%20%5Cu2022%20Recovery%20of%20viable%20sorted%20bacterial%20populations%20for%20downstream%20characterization.%22%2C%22date%22%3A%222026-12%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.mex.2026.104194%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%2242898643%22%2C%22PMCID%22%3A%22PMC13677978%22%2C%22ISSN%22%3A%222215-0161%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-10-21T09%3A51%3A49Z%22%7D%7D%2C%7B%22key%22%3A%22Q4DZ3WS5%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Elfarkouchi%20et%20al.%22%2C%22parsedDate%22%3A%222026-11-02%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BElfarkouchi%2C%20Abir%2C%20Arthur%20Vitard%2C%20L%26%23xE9%3Ba%20Mammri%2C%20et%20al.%202026.%20%26%23x201C%3BA%20Structural%20Model%20for%20the%20Autoinhibition%20of%20the%20%26%23x3B3%3B-TuRC-Activating%20CM1%20Domain.%26%23x201D%3B%20%26lt%3Bi%26gt%3BThe%20Journal%20of%20Cell%20Biology%26lt%3B%5C%2Fi%26gt%3B%20225%20%2811%29%3A%20e202605160.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1083%5C%2Fjcb.202605160%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1083%5C%2Fjcb.202605160%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20structural%20model%20for%20the%20autoinhibition%20of%20the%20%5Cu03b3-TuRC-activating%20CM1%20domain%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abir%22%2C%22lastName%22%3A%22Elfarkouchi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arthur%22%2C%22lastName%22%3A%22Vitard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L%5Cu00e9a%22%2C%22lastName%22%3A%22Mammri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%5Cu00e9bastien%22%2C%22lastName%22%3A%22Brier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lola%22%2C%22lastName%22%3A%22Tanneur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00e9cile%22%2C%22lastName%22%3A%22Hu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lien%22%2C%22lastName%22%3A%22Thureau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Joly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francoise%22%2C%22lastName%22%3A%22Ochsenbein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%20T.%22%2C%22lastName%22%3A%22Conduit%22%7D%5D%2C%22abstractNote%22%3A%22Microtubule%20nucleation%20by%20%5Cu03b3-tubulin%20ring%20complexes%20%28%5Cu03b3-TuRCs%29%20must%20be%20spatiotemporally%20controlled%20to%20avoid%20major%20cell%20division%20errors.%20%5Cu03b3-TuRCs%20are%20activated%20by%20the%20centrosome-specific%20binding%20of%20a%20highly%20conserved%20centrosomin%20motif%201%20%28CM1%29%20domain%2C%20but%20how%20binding%20is%20prevented%20in%20the%20cytosol%20remains%20unclear.%20We%20provide%20the%20first%20structural%20explanation%20for%20CM1%20autoinhibition%2C%20revealing%20that%20stable%20intramolecular%20interactions%20mediate%20cooperative%20folding%20to%20block%20%5Cu03b3-TuRC-binding%20interfaces.%20Using%20various%20structural%20approaches%2C%20we%20show%20that%20CM1%20forms%20a%20conserved%20dimeric%20coiled-coil%20hairpin%20that%20sequesters%20a%20key%20phenylalanine%20residue%20essential%20for%20%5Cu03b3-TuRC%20binding.%20This%20appears%20sufficient%20for%20autoinhibition%20in%20humans%2C%20but%20in%20flies%20autoinhibition%20requires%20the%20association%20of%20an%20upstream%20CM1%20autoinhibition%20%28CAI%29%20domain%2C%20which%20forms%20a%204-helix%20dimer%20that%20covers%20the%20opposite%20phenylalanine%20residue%20of%20the%20hairpin%20dimer.%20Collectively%2C%20the%20data%20provide%20the%20first%20structural%20model%20for%20CM1%20autoinhibition%20and%20reveal%20evolutionary%20differences%20across%20species.%22%2C%22date%22%3A%222026-11-02%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1083%5C%2Fjcb.202605160%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%2242814412%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221540-8140%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-10-01T12%3A01%3A26Z%22%7D%7D%2C%7B%22key%22%3A%22FCF6WTDR%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Funke%20et%20al.%22%2C%22parsedDate%22%3A%222026-10-28%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFunke%2C%20Pauline%2C%20Mathilde%20Roth%2C%20Thibaud%20Dieudonn%26%23xE9%3B%2C%20and%20Guillaume%20Lenoir.%202026.%20%26%23x201C%3BRecent%20Advances%20in%20Understanding%20the%20Regulatory%20Mechanisms%20of%20P4-ATPase%20Lipid%20Flippases.%26%23x201D%3B%20%26lt%3Bi%26gt%3BBiochemical%20Society%20Transactions%26lt%3B%5C%2Fi%26gt%3B%2054%20%2810%29%3A%201407%26%23x2013%3B17.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1042%5C%2FBST20260203%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1042%5C%2FBST20260203%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Recent%20advances%20in%20understanding%20the%20regulatory%20mechanisms%20of%20P4-ATPase%20lipid%20flippases%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pauline%22%2C%22lastName%22%3A%22Funke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathilde%22%2C%22lastName%22%3A%22Roth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thibaud%22%2C%22lastName%22%3A%22Dieudonn%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Lenoir%22%7D%5D%2C%22abstractNote%22%3A%22P4-ATPases%20establish%20and%20maintain%20transbilayer%20lipid%20asymmetry%20in%20eukaryotic%20membranes%20by%20transporting%20phospholipids%20from%20the%20exoplasmic%20to%20the%20cytosolic%20membrane%20leaflet%20at%20the%20expense%20of%20ATP%20hydrolysis.%20In%20recent%20years%2C%20biochemical%20analysis%20together%20with%20an%20increasing%20number%20of%20cryo-electron%20microscopy%20structures%20has%20substantially%20increased%20our%20understanding%20of%20the%20lipid%20transport%20cycle%20and%20substrate%20recognition%20by%20P4-ATPases.%20However%2C%20the%20underlying%20molecular%20mechanism%20governing%20P4-ATPase%20activation%20and%20regulation%20remains%20less%20well%20understood.%20The%20present%20review%20aims%20to%20summarize%20current%20insights%20into%20the%20molecular%20mechanisms%20controlling%20P4-ATPase%20activation%20and%20regulation.%20We%20discuss%20autoinhibition%20by%20N-%20and%20C-terminal%20extensions%2C%20activation%20by%20regulatory%20lipids%2C%20particularly%20phosphoinositides%2C%20regulation%20by%20interacting%20proteins%20including%20small%20GTPases%20and%20guanine%20nucleotide%20exchange%20factors%2C%20and%20post-translational%20modifications%2C%20especially%20phosphorylation.%20Together%2C%20these%20studies%20reveal%20that%20P4-ATPase%20activity%20is%20controlled%20by%20a%20complex%20and%20multilayered%20regulatory%20network%20that%20enables%20precise%20control%20of%20lipid%20transport.%20Future%20studies%20combining%20structural%2C%20biochemical%2C%20and%20cellular%20approaches%20will%20be%20essential%20to%20elucidate%20how%20these%20mechanisms%20cooperate%20to%20maintain%20membrane%20lipid%20homeostasis%20and%20support%20diverse%20cellular%20functions.%22%2C%22date%22%3A%222026-10-28%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1042%5C%2FBST20260203%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%2242831388%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221470-8752%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-10-06T08%3A56%3A45Z%22%7D%7D%2C%7B%22key%22%3A%223R2BED6N%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Martin%20and%20Fiorucci%22%2C%22parsedDate%22%3A%222026-10-20%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMartin%2C%20Guillaume%20T.%2C%20and%20Anne-Sophie%20Fiorucci.%202026.%20%26%23x201C%3BThe%20Heat%20Is%20on%20for%20Plant%20Nitrogen%20Nutrition.%26%23x201D%3B%20%26lt%3Bi%26gt%3BTrends%20in%20Plant%20Science%26lt%3B%5C%2Fi%26gt%3B%2C%20October%2020%2C%20S1360-1385%2826%2900304-3.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.tplants.2026.09.010%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.tplants.2026.09.010%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20heat%20is%20on%20for%20plant%20nitrogen%20nutrition%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%20T.%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Sophie%22%2C%22lastName%22%3A%22Fiorucci%22%7D%5D%2C%22abstractNote%22%3A%22Global%20warming%20leads%20to%20increased%20average%20atmospheric%20temperatures%2C%20which%20will%20inevitably%20have%20an%20impact%20on%20plant%20growth%20and%20crop%20yields.%20It%20is%20essential%20to%20understand%20how%20plant%20nutrition%20will%20be%20affected%20by%20elevated%20temperatures.%20Nitrogen%20is%20one%20of%20the%20major%20mineral%20nutrients%2C%20and%20its%20uptake%20is%20enhanced%20during%20the%20light%20period%2C%20peaking%20at%20the%20day%5C%2Fnight%20transition%2C%20whereas%20its%20storage%2C%20especially%20in%20the%20form%20of%20nitrate%20%28NO3-%29%2C%20is%20favoured%20in%20the%20dark.%20Given%20the%20overlap%20between%20light%20and%20temperature%20responses%2C%20we%20review%20the%20interaction%20between%20nitrogen%20nutrition%20and%20light%20responses%20and%20place%20this%20in%20the%20context%20of%20new%20findings%20on%20temperature%20sensing.%20We%20also%20suggest%20new%20hypotheses%20on%20the%20potential%20links%20between%20temperature%20and%20NO3-%20homeostasis.%22%2C%22date%22%3A%222026-10-20%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.tplants.2026.09.010%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%2242901853%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221878-4372%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-10-21T09%3A49%3A51Z%22%7D%7D%2C%7B%22key%22%3A%22YJWY6RXP%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Llansola-Portoles%20et%20al.%22%2C%22parsedDate%22%3A%222026-10-16%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLlansola-Portoles%2C%20Manuel%20J.%2C%20James%20Sturgis%2C%20Andrew%20Gall%2C%20et%20al.%202026.%20%26%23x201C%3BThe%20Vibronic%20Landscape%20of%20Excitons%20in%20Photosynthetic%20Antennae.%26%23x201D%3B%20%26lt%3Bi%26gt%3BPhysical%20Chemistry%20Chemical%20Physics%3A%20PCCP%26lt%3B%5C%2Fi%26gt%3B%2C%20ahead%20of%20print%2C%20October%2016.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1039%5C%2Fd6cp02540d%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1039%5C%2Fd6cp02540d%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20vibronic%20landscape%20of%20excitons%20in%20photosynthetic%20antennae%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manuel%20J.%22%2C%22lastName%22%3A%22Llansola-Portoles%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%22%2C%22lastName%22%3A%22Sturgis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Gall%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juan%20J.%22%2C%22lastName%22%3A%22Romero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20A.%22%2C%22lastName%22%3A%22Pascal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leonas%22%2C%22lastName%22%3A%22Valkunas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Robert%22%7D%5D%2C%22abstractNote%22%3A%22Light%20harvesting%20and%20excitation%20energy%20transfer%20in%20photosynthesis%20generally%20involve%20chlorophyll%20molecules%20held%20by%20their%20host%20proteins%20at%20short%20distances%20from%20each%20other%2C%20resulting%20in%20excitonic%20coupling.%20The%20transfer%20of%20excitation%20energy%20to%20the%20reaction%20centres%20consists%20of%20exciton%20migration%20and%20relaxation%20within%20and%20between%20photosynthetic%20proteins.%20The%20dynamics%20of%20this%20process%20depend%20on%20excitonic%20coupling%20between%20the%20pigments%2C%20on%20the%20energy%20gaps%20and%20reorganisation%20energies%20of%20the%20excited%20states%20involved%2C%20on%20the%20disorder%20imposed%20by%20the%20proteins%2C%20and%20on%20the%20vibrational%20modes%20resonant%20with%20these%20gaps.%20The%20precise%20structures%20and%20vibrational%20landscapes%20of%20excitons%20are%20thus%20essential%20knowledge%20for%20understanding%20the%20amazing%20efficiency%20of%20photosynthesis.%20In%20this%20work%2C%20we%20characterise%20the%20vibrational%20properties%20of%20excitons%20in%20light-harvesting%20proteins%20from%20purple%20photosynthetic%20bacteria%2C%20which%20indicate%20on%20how%20many%20bacteriochlorophylls%20they%20reside%20and%20suggest%20in%20which%20proportions.%20Vibrational%20spectra%20obtained%20from%20bacteriochlorophylls%20in%20proteins%20generally%20contain%20additional%20vibronic%20contributions%20when%20compared%20to%20isolated%20pigments%2C%20which%20could%20open%20additional%20pathways%20for%20vibrationally%20assisted%20excitation%20energy%20transfer.%20In%20contrast%2C%20the%20absence%20of%20new%20vibronic%20contributions%20in%20the%20spectra%20of%20the%20chlorophyll-containing%20proteins%20studied%20here%20above%20100%20cm-1%20suggests%20that%20in%20these%20complexes%2C%20vibrationally%20assisted%20excitation%20energy%20transfer%20occurs%20through%20the%20vibrational%20modes%20of%20chlorophyll%20molecules%20in%20an%20equilibrium%20configuration.%22%2C%22date%22%3A%222026-10-16%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1039%5C%2Fd6cp02540d%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%2242885246%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221463-9084%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-10-19T08%3A20%3A15Z%22%7D%7D%2C%7B%22key%22%3A%22D8E55VHF%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Michel%20et%20al.%22%2C%22parsedDate%22%3A%222026-10-14%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMichel%2C%20Laurane%2C%20Sophia%20Godel-Pastre%2C%20Narjis%20Ouazzani%2C%20et%20al.%202026.%20%26%23x201C%3BDecoupling%20Photophysical%20Brightness%20and%20Cellular%20Imaging%20Efficiency%20in%204-ANI-Based%20Fluorophores%3A%20The%20Critical%20Role%20of%20Sterically%20Hindered%20N-Substituents.%26%23x201D%3B%20%26lt%3Bi%26gt%3BChembiochem%3A%20A%20European%20Journal%20of%20Chemical%20Biology%26lt%3B%5C%2Fi%26gt%3B%2027%20%2819%29%3A%20e70553.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fcbic.70553%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fcbic.70553%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Decoupling%20Photophysical%20Brightness%20and%20Cellular%20Imaging%20Efficiency%20in%204-ANI-Based%20Fluorophores%3A%20The%20Critical%20Role%20of%20Sterically%20Hindered%20N-Substituents%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurane%22%2C%22lastName%22%3A%22Michel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophia%22%2C%22lastName%22%3A%22Godel-Pastre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Narjis%22%2C%22lastName%22%3A%22Ouazzani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M%5Cu00e9lina%22%2C%22lastName%22%3A%22Fabe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Siham%20El%22%2C%22lastName%22%3A%22Mounquad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Micka%5Cu00ebl%22%2C%22lastName%22%3A%22Bourge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%22%2C%22lastName%22%3A%22Deville-Foillard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Chevalier%22%7D%5D%2C%22abstractNote%22%3A%22In%20this%20article%2C%20we%20report%20the%20screening%20of%20a%20library%20of%20twenty-one%204-ANI-based%20fluorophores%2C%20leading%20to%20the%20identification%20of%20a%20novel%20cycloheptylamine-containing%20derivative%20with%20outstanding%20performance%20for%20cellular%20imaging.%20This%20compound%20exhibits%20fluorescence%20intensities%20more%20than%20tenfold%20higher%20than%20those%20of%20most%20analogs%2C%20enabling%20its%20use%20at%20submicromolar%20concentrations%20with%20minimal%20perturbation%20of%20cellular%20function.%20Beyond%20this%20lead%20discovery%2C%20our%20results%20highlight%20a%20critical%20disconnect%20between%20photophysical%20properties%20in%20aqueous%20media%20and%20imaging%20efficiency%20in%20biological%20systems.%20By%20combining%20multiple%20analytical%20techniques%2C%20including%20photophysics%2C%20fluorescence%20microscopy%2C%20and%20flow%20cytometry%20as%20well%20as%20computational%20DFT%20calculations%2C%20we%20demonstrate%20that%20sterically%20hindered%20N-substituents%20play%20a%20critical%20role%20by%20combining%20efficient%20cellular%20uptake%20and%20good%20solubility%2C%20two%20essential%20features%20that%20govern%20probe%20performance%20for%20cell%20imaging.%20These%20findings%20challenge%20the%20conventional%20reliance%20on%20intrinsic%20brightness%20as%20a%20design%20criterion%20and%20emphasize%20the%20necessity%20of%20integrating%20biological%20context%20into%20the%20evaluation%20and%20development%20of%20fluorescent%20imaging%20agents.%22%2C%22date%22%3A%222026-10-14%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1002%5C%2Fcbic.70553%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%2242809585%22%2C%22PMCID%22%3A%22PMC13623105%22%2C%22ISSN%22%3A%221439-7633%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-09-30T13%3A24%3A07Z%22%7D%7D%2C%7B%22key%22%3A%224SSNLNUQ%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pecourneau%20et%20al.%22%2C%22parsedDate%22%3A%222026-10-13%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPecourneau%2C%20Jeremy%2C%20Jimmy%20Richard%2C%20Brigitte%20Meunier%2C%20et%20al.%202026.%20%26%23x201C%3BSynthesis%20and%20Antischistosomal%20Activity%20Profile%20of%20Several%20Sub-Series%20of%20Redox-Active%20Lead%203%26%23x2011%3BBenzylmenadiones%26%23xE5F8%3BInvestigations%20of%20the%20Modes%20of%20Action%20in%20Yeast.%26%23x201D%3B%20%26lt%3Bi%26gt%3BACS%20Omega%26lt%3B%5C%2Fi%26gt%3B%2011%20%2840%29%3A%2061479%26%23x2013%3B95.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1021%5C%2Facsomega.6c06911%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1021%5C%2Facsomega.6c06911%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Synthesis%20and%20Antischistosomal%20Activity%20Profile%20of%20Several%20Sub-Series%20of%20Redox-Active%20Lead%203%5Cu2011Benzylmenadiones%5Cue5f8Investigations%20of%20the%20Modes%20of%20Action%20in%20Yeast%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremy%22%2C%22lastName%22%3A%22Pecourneau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jimmy%22%2C%22lastName%22%3A%22Richard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brigitte%22%2C%22lastName%22%3A%22Meunier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maude%22%2C%22lastName%22%3A%22Dagenais%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00e9cile%22%2C%22lastName%22%3A%22H%5Cu00e4berli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20L.%22%2C%22lastName%22%3A%22Williams%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%22%2C%22lastName%22%3A%22Keiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisabeth%22%2C%22lastName%22%3A%22Davioud-Charvet%22%7D%5D%2C%22abstractNote%22%3A%22Three%20sub-series%20of%203-benzylmenadiones%20were%20discovered%20as%20new%20antischistosomal%20agents.%20The%20most%20potent%20representatives%2C%20called%20schistodiones%2C%20exhibited%20IC50%20values%20%26lt%3B5%20%5Cu03bcM%20against%20larvae%20and%20ex%20vivo%20Schistosoma%20mansoni%20adult%20worms%20and%20moderate%20activity%20per%20os%20in%20the%20S.%20mansoni-infected%20mouse%20model%20in%20vivo.%20We%20synthesized%20the%20putative%203-benzoylmenadione%20metabolites%20of%20the%20most%20active%20compounds%20and%20explored%20the%20possible%20mode%28s%29%20of%20action%20using%20the%20yeast%20model%20and%20the%20recombinant%20drug%20target%20S.%5Cu00a0mansoni%20thioredoxin-glutathione%20reductase.%20Two%20drug%20targets%20were%20identified%20in%20yeast%3A%20the%20yeast%20NADH%20dehydrogenase%20and%20Cox15%2C%20involved%20in%20events%20responsible%20for%20respiratory%20growth%20defect%20in%20yeast%2C%20respectively%3A%20%28i%29%20the%20bioreductive%20activation%20step%20producing%20reactive%20oxygen%20species%20and%20%28ii%29%20the%20heme%20a%20synthase%20inhibition.%20These%20two%20drug%20targets%20are%20discussed%20in%20the%20context%20of%20S.mansoni%20biology%2C%20with%20S.%20mansoni%20thioredoxin-glutathione%20reductase%20redox-cycling%20and%20a%20potential%20source%20of%20oxidative%20stress%20in%20the%20parasite.%22%2C%22date%22%3A%222026-10-13%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1021%5C%2Facsomega.6c06911%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%2242889854%22%2C%22PMCID%22%3A%22PMC13670326%22%2C%22ISSN%22%3A%222470-1343%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-10-19T08%3A21%3A23Z%22%7D%7D%2C%7B%22key%22%3A%226RWAF343%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22K%5Cu00fcbelbeck%20et%20al.%22%2C%22parsedDate%22%3A%222026-10-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BK%26%23xFC%3Bbelbeck%2C%20Tanja%2C%20Anna%20Stastny%2C%20Niklas%20Beumer%2C%20et%20al.%202026.%20%26%23x201C%3BH2A.J%20Is%20an%20Epigenetic%20Driver%20of%20IL-17-Associated%20Inflammation%20in%20TH17%20Cells%20and%20Keratinocytes.%26%23x201D%3B%20%26lt%3Bi%26gt%3BMolecular%20Biomedicine%26lt%3B%5C%2Fi%26gt%3B%207%20%281%29%3A%20199.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs43556-026-00611-4%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs43556-026-00611-4%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22H2A.J%20is%20an%20epigenetic%20driver%20of%20IL-17-associated%20inflammation%20in%20TH17%20cells%20and%20keratinocytes%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tanja%22%2C%22lastName%22%3A%22K%5Cu00fcbelbeck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22Stastny%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niklas%22%2C%22lastName%22%3A%22Beumer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antonia%22%2C%22lastName%22%3A%22Kolb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tanja%22%2C%22lastName%22%3A%22Knopp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Berenice%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dennis%22%2C%22lastName%22%3A%22Fritsche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ana-Marija%22%2C%22lastName%22%3A%22Kulis-Mandic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Klein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariia%22%2C%22lastName%22%3A%22Antipova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bettina%22%2C%22lastName%22%3A%22Mros%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Delacher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ari%22%2C%22lastName%22%3A%22Waisman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carl%22%2C%22lastName%22%3A%22Mann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%20E.%22%2C%22lastName%22%3A%22R%5Cu00fcbe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susanne%22%2C%22lastName%22%3A%22Karbach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bj%5Cu00f6rn%20E.%22%2C%22lastName%22%3A%22Clausen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carsten%22%2C%22lastName%22%3A%22Deppermann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miriam%22%2C%22lastName%22%3A%22Wittmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniela%22%2C%22lastName%22%3A%22Kramer%22%7D%5D%2C%22abstractNote%22%3A%22Psoriasis%20is%20a%20common%20autoinflammatory%20disease%20driven%20by%20excessive%20IL-17%20expression.%20While%20the%20pathomechanism%20of%20the%20disease%20has%20been%20revealed%2C%20epigenetic%20factors%20contributing%20to%20psoriasis%20are%20less%20well%20understood.%20Here%2C%20we%20investigated%20the%20role%20of%20the%20poorly%20studied%20histone%20variant%20H2A.J%20in%20psoriasis.%20We%20found%20that%20H2A.J%20gets%20overexpressed%20in%20the%20skin%20of%20psoriasis%20patients%2C%20with%20even%20non-lesional%20skin%20showing%20increased%20expression%20compared%20to%20the%20skin%20of%20healthy%20donors.%20To%20gain%20mechanistic%20insights%2C%20we%20studied%20mice%20with%20a%20global%20H2A.J%20knockout%20%28KO%29%20and%20found%20them%20to%20be%20partially%20protected%20against%20experimentally%20induced%20psoriasis%2C%20highlighted%20by%20reduced%20immune%20cell%20infiltration%20and%20less%20hyperkeratosis.%20Molecularly%2C%20psoriatic%20skin%20of%20H2A.J%20KO%20mice%20showed%20diminished%20expression%20of%20chemokines%20and%20cytokines%2C%20including%20CXCL1%2C%20CCL3%2C%20and%20IL-17A.%20This%20phenotype%20could%20partially%20be%20explained%20by%20the%20role%20of%20H2A.J%20as%20a%20key%20regulator%20of%20IL-17A-responsive%20genes%20in%20keratinocytes.%20Furthermore%2C%20we%20uncovered%20a%20T-cell-intrinsic%20function%20of%20H2A.J%2C%20which%20specifically%20promoted%20the%20expression%20of%20effector%20molecules%20such%20as%20Il17a%20and%20Il17f%20in%20TH17%20cells.%20Our%20findings%20from%20human%20skin%20and%20murine%20psoriasis%20models%20imply%20that%20H2A.J%20acts%20as%20a%20key%20epigenetic%20regulator%20of%20IL-17-associated%20inflammation%2C%20which%20controls%20the%20%28chronic%29%20activation%20of%20TH17%20cells%20and%20keratinocytes%20in%20psoriasis.%22%2C%22date%22%3A%222026-10-08%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs43556-026-00611-4%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%2242848102%22%2C%22PMCID%22%3A%22PMC13650110%22%2C%22ISSN%22%3A%222662-8651%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-10-12T15%3A03%3A19Z%22%7D%7D%2C%7B%22key%22%3A%22GZDYM4ZI%22%2C%22library%22%3A%7B%22id%22%3A3888256%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bercy%20et%20al.%22%2C%22parsedDate%22%3A%222026-10-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBercy%2C%20Roxanne%2C%20Juan%20J.%20Romero%2C%20Radek%20Litvin%2C%20et%20al.%202026.%20%26%23x201C%3BDistortion-Induced%20Tuning%20of%20Chlorophyll%20a%20Electronic%20Properties%20in%20LHC%20Proteins.%26%23x201D%3B%20%26lt%3Bi%26gt%3BBiochimica%20Et%20Biophysica%20Acta.%20Bioenergetics%26lt%3B%5C%2Fi%26gt%3B%2C%20October%206%2C%20149614.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.bbabio.2026.149614%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.bbabio.2026.149614%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Distortion-induced%20tuning%20of%20chlorophyll%20a%20electronic%20properties%20in%20LHC%20proteins%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roxanne%22%2C%22lastName%22%3A%22Bercy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juan%20J.%22%2C%22lastName%22%3A%22Romero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Radek%22%2C%22lastName%22%3A%22Litvin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Finkelstein-Shapiro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristian%22%2C%22lastName%22%3A%22Ilioaia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20A.%22%2C%22lastName%22%3A%22Pascal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manuel%20J.%22%2C%22lastName%22%3A%22Llansola-Portoles%22%7D%5D%2C%22abstractNote%22%3A%22In%20eukaryotic%20light-harvesting%20complexes%2C%20the%20protein%20host%20tunes%20chlorophyll-a%20%28Chl%20a%29%20site%20energies%20through%20a%20number%20of%20mechanisms%20%28e.g.%20hydrogen%20bonding%3B%20excitonic%5C%2Fcharge-transfer%20%28CT%29%20mixing%29.%20However%2C%20whether%20protein-imposed%20macrocycle%20distortions%20also%20contribute%20to%20fine-tuning%20this%20energy%20remains%20unclear.%20We%20have%20investigated%20three%20Chl%20a-only%20algal%20antennas%20-%20VCP%20%28from%20Nannochloropsis%20oceanica%29%2C%20rVCP%20%28Trachydiscus%20minutus%29%2C%20and%20CLH%20%28Chromera%20velia%29.%20These%20complexes%20show%20distinct%20red-shifted%20absorption%20features%2C%20which%20at%2077%5Cu202fK%20range%20from%20670%5Cu202fnm%20up%20to%20an%20extremely%20red-shifted%20band%20at%20700%5Cu202fnm%20%28rVCP%29.%20By%20analysis%20of%20marker%20bands%20in%20excitation-selective%20resonance%20Raman%20spectra%2C%20we%20have%20determined%20the%20contribution%20of%20%28i%29%20hydrogen%20bonding%20to%20the%20keto%20group%20%281630-1700%5Cu202fcm-1%20region%29%2C%20and%5C%2For%20%28ii%29%20macrocycle%20distortion%20%28bands%20near%201555%20and%201612%5Cu202fcm-1%29%20to%20these%20red-shifts.%20Finally%2C%20the%20absence%20of%20vibrational%20features%20in%20fluorescence%20line-narrowing%20measurements%20for%20the%20reddest%20rVCP%20band%20is%20consistent%20with%20strong%20excitonic%20coupling%2C%20which%20we%20suggest%20is%20at%20the%20origin%20of%20this%20large%20red%20shift.%20Our%20results%20indicate%20that%20tuning%20of%20the%20functional%20properties%20of%20Chl%20a%20antennas%20may%20occur%20via%20distortion%20of%20the%20macrocycle.%22%2C%22date%22%3A%222026-10-06%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.bbabio.2026.149614%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%2242838278%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221879-2650%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-10-07T13%3A48%3A14Z%22%7D%7D%5D%7D
Boëffard-Dosierre, Liza, Camille Dagallier, Géraldine Eudier, et al. 2026. “NMR Detects Clustering and Ultra-Weak Excipient Interactions Governing Monoclonal Antibody Viscosity in Formulation-Relevant Conditions.” mAbs 18 (1): 2685366. https://doi.org/10.1080/19420862.2026.2685366.
Toukabri, Hasna, Christophe Buisson, Yves Le Vern, Alix Sausset, Mickaël Bourge, and Leyla Slamti. 2026. “FACS-Based Isolation and Recovery of Physiologically Distinct Bacterial Subpopulations from Infected Insect Hosts.” MethodsX 17 (December): 104194. https://doi.org/10.1016/j.mex.2026.104194.
Elfarkouchi, Abir, Arthur Vitard, Léa Mammri, et al. 2026. “A Structural Model for the Autoinhibition of the γ-TuRC-Activating CM1 Domain.” The Journal of Cell Biology 225 (11): e202605160. https://doi.org/10.1083/jcb.202605160.
Funke, Pauline, Mathilde Roth, Thibaud Dieudonné, and Guillaume Lenoir. 2026. “Recent Advances in Understanding the Regulatory Mechanisms of P4-ATPase Lipid Flippases.” Biochemical Society Transactions 54 (10): 1407–17. https://doi.org/10.1042/BST20260203.
Martin, Guillaume T., and Anne-Sophie Fiorucci. 2026. “The Heat Is on for Plant Nitrogen Nutrition.” Trends in Plant Science, October 20, S1360-1385(26)00304-3. https://doi.org/10.1016/j.tplants.2026.09.010.
Llansola-Portoles, Manuel J., James Sturgis, Andrew Gall, et al. 2026. “The Vibronic Landscape of Excitons in Photosynthetic Antennae.” Physical Chemistry Chemical Physics: PCCP, ahead of print, October 16. https://doi.org/10.1039/d6cp02540d.
Michel, Laurane, Sophia Godel-Pastre, Narjis Ouazzani, et al. 2026. “Decoupling Photophysical Brightness and Cellular Imaging Efficiency in 4-ANI-Based Fluorophores: The Critical Role of Sterically Hindered N-Substituents.” Chembiochem: A European Journal of Chemical Biology 27 (19): e70553. https://doi.org/10.1002/cbic.70553.
Pecourneau, Jeremy, Jimmy Richard, Brigitte Meunier, et al. 2026. “Synthesis and Antischistosomal Activity Profile of Several Sub-Series of Redox-Active Lead 3‑BenzylmenadionesInvestigations of the Modes of Action in Yeast.” ACS Omega 11 (40): 61479–95. https://doi.org/10.1021/acsomega.6c06911.
Kübelbeck, Tanja, Anna Stastny, Niklas Beumer, et al. 2026. “H2A.J Is an Epigenetic Driver of IL-17-Associated Inflammation in TH17 Cells and Keratinocytes.” Molecular Biomedicine 7 (1): 199. https://doi.org/10.1186/s43556-026-00611-4.
Bercy, Roxanne, Juan J. Romero, Radek Litvin, et al. 2026. “Distortion-Induced Tuning of Chlorophyll a Electronic Properties in LHC Proteins.” Biochimica Et Biophysica Acta. Bioenergetics, October 6, 149614. https://doi.org/10.1016/j.bbabio.2026.149614.