Function and architecture
of macromolecular assemblies

Presentation

The FAAM team is studying the mechanisms involved in biological processes at the molecular level using structural and biochemical techniques. We apply X-ray crystallography and cryo-EM to analyse the atomic structure of target proteins and complexes and also use SAXS to study the conformation of these complexes in solution. The team is focusing on the assembly of protein complexes involved in a variety of cellular processes. The team’s main research projects concern genome replication and the cell-cell communication in bacteria, maturation of tRNAs and avirulence proteins produced by pathogenic fungi. In addition, our expertise in cloning, protein expression, purification and determination of 3D structures is exploited to carry out a considerable number of collaborative projects.

Research Projects

Methodologies

Team

Team Leader

Pr-UPSaclay

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Pr-UPSaclay
PI

MdC-Sorbonne-Université

MdC-UPSaclay

T-UPSaclay

PhD student

Training

  • Sylvie Nessler
  • Bruno Collinet
  • Dominique Liger
  • Karine Blondeau
  • Herman Van Tilbeurgh

Click on the Professor 's name to see the trainings

L1 Organisation moléculaire du vivant (SorbonneUniversité https://sciences.sorbonne-universite.fr/formation-sciences/licences/cycle-dintegration-l1/portail-sciences-de-la-nature)

 

L1 PASS disciplinaire biologie (SorbonneUniversité https://sante.sorbonne-universite.fr/formations/etudes-medicales/pass-et-las)

 

L3 Biochimie : enzymologie approfondie (SorbonneUniversité http://www.licence.sdv.upmc.fr/fr/pdf/2020-2021/fiches/LU3SV513.pdf)

 

M1 Structure, assemblage et ingénierie des protéines (SorbonneUniversité https://sciences.sorbonne-universite.fr/sites/default/files/media/2019-11/mu4bm134.pdf)

 

M2 Biochimie et génétique de l’ARN (SorbonneUniversité http://www.master.bmc.sorbonne-universite.fr/fr/master-2/genetique-epigenetique/m2-biochimie-genetique-de-l-arn-bga.html)

 

L3 parcours Interface Biologie-Chimie (iBC) : https://ecole-universitaire-paris-saclay.fr/formation/licence/sciences-de-la-vie/l3-interface-biologie-chimie

 

L3 parcours Biologie des Organismes et Écologie (BOE) : https://ecole-universitaire-paris-saclay.fr/formation/licence/sciences-de-la-vie/l3-biologie-des-organismes-et-ecologie-0

 

Master Biologie santé : https://www.universite-paris-saclay.fr/formation/master/biologie-sante

 

M1 Life Sciences and Health - International Track : https://www.universite-paris-saclay.fr/formation/master/biologie-sante/m1-life-sciences-and-health-international-track-france

 

M1 Biologie-Santé - Plateforme Biochimie et biotechnologies : https://www.universite-paris-saclay.fr/formation/master/biologie-sante/m1-biologie-sante-plateforme-biochimie-et-biotechnologies-site-evry

 

M2 Ingénierie et Chimie des Biomolécules : https://www.universite-paris-saclay.fr/formation/master/chimie/m2-ingenierie-et-chimie-des-biomolecules

Latest publications

You can find the latest publications at the end of each specific research projects page. 

For all the publications of the Team click on the button below.

External fundings

ANR-15-CE12-0003-01 (sRNA-Fit, 2017-2021)
ANR-19-CE12-0006-01 (RRARE, 2019-2023)].

AMR 2021
ANTIBIORESISTANCE: COMPRENDRE, INNOVER, AGIR

Project title
Narrow spectrum antibiotics to fight the emergence of bacterial resistance

Scientific coordinator : ARTHUR, Michel, DR1 INSERM, Université de Paris

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