Our team combines experimental and computational strategies to unravel the molecular bases underlying the dynamic assembly of specific protein interaction networks. Focused on the complexes involved in maintaining genome integrity, we characterize the structure of the complexes, develop new methods for the prediction of their conformations and design inhibitory compounds capable of disrupting these interactions.
Our projects aim at unravelling how these physical interactions ensure proper cross-talks between cell machineries and signaling pathways enabling cells to resist to specific stresses. We focus on protein machineries involved in modulating the establishment of epigenetic information and acting in recombination processes.