Replication and assembly of poxviruses

Being obligatory intracellular parasites, viruses infect a specific host and hijack the cellular machinery to replicate themselves.

With cryo-electron tomography, I aim at investigating virus-host interactions at the molecular resolution and in native state directly inside infected cells.

Our projects aim at elucidating key aspects of poxvirus replication and assembly by focusing on the remodelling of cellular organelles and the 3D reorganization of the intracellular space upon infection.