Bacteriophage T5

Exploring how bacteriophage T5 takes over host functions and how the viral particle self-assembles in bacteria:
A fundamental research approach for the development of new biotechnological tools

Overview

The bacteriophage T5 is a virulent virus that infects the Gram-negative bacteria Escherichia coli. Many original features of T5 make it an attractive model to understand fundamental aspects of host takeover and viral particle assembly. These two lines of research open perspectives to develop new biotechnological tools.

Topics

team

Pascale BOULANGER

Group Leader

Research Director

Ombeline ROSSIER

Researcher

Müge SENARISOY

Researcher

Madalena RENOUARD

Technician

Nicolas DUCROT

PhD student

Raphaël VATIN

Intern Student

Charlène BEILLON

Master Intern

Former members and Alumni

Lucienne Letellier (Emeritus DR1 CNRS)

Luis Ramirez-Chamorro (PhD 2016-2020)

Léo Zangelmi (PhD 2015-2018)

Émeline Vernhes (PhD 2013 -2016)

Olivier Preux (PhD 2009 -2012)

Alexis Huet (Post-Doc 2008 – 2010)

Collaborations and networks

  • Alexis Huet and James Conway (University of Pittsburgh): structure and assembly of T5 Capsid by Cryo-electron microcopy approaches
  • Cecile Breyton (IBS Grenoble): structure of T5 tail and mechanism of T5 DNA transfer through the bacterial envelope
  • Christophe Masselon (IRIG, CEA Grenoble) and Sebastien Hentz (LETI, CEA Grenoble): analysis of T5 capsid by proteomic and NEMS mass spectrometry approaches
  • Mireille Ansaldi (LCB Marseille) and Herman van Tilbeurgh (I2BC, Gif sur Yvette): partners of the ANR TakeoverBac (ANR-17-CE11-0038)

The team is a member of the French Phage network   

External funding

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