Molecular Microbiology
of Actinobacteria

Our team is interested in the specialized metabolism of Actinobacteria

Specialized metabolites are small organic molecules produced by plants and micro-organisms. As opposed to primary metabolites, specialized metabolites are not essential to the survival of the producing organism. Yet, they thought to confer a fitness advantage to the producers in their ecological niche.

Research projects

Our work focuses mainly on the specialized metabolism of Streptomyces species. Streptomyces are Gram+ filamentous bacteria ubiquitous in Nature. Streptomyces bacteria possess a linear, GC-rich chromosome of 8 to 10 Mb. They have a complex morphological cycle: the germination of a spore gives rise to a vegetative mycelium that develops in close contact with the nutritious substrate. This first phase of growth is followed by a pause called the transition phase. During this pause, the bacteria are thought to assess the nutritional content of its growth medium. If the nutrients are still abundant, a second phase of vegetative growth will follow the first one but if nutrients are scarce, an aerial mycelium will arise from the vegetative mycelium. The tip ends of the aerial hyphae will then differentiate into spores. This morphological differentiation, triggered by a nutritional limitation, is intricately linked to a metabolic differentiation resulting in the production of molecules called “secondary metabolites” presenting a large diversity of chemical structures and biological activities (antimicrobial, antitumoral, immunosuppressive or herbicidal activities for example).

Streptomyces development cycle

The research carried out by the team mainly concerns the biosynthesis of specialized metabolites and the engineering of these pathways by synthetic biology.

Topics

team

Sylvie LAUTRU

Group Leader

Researcher

Jean-Luc PERNODET

Research director

Armel GUYONVARCH

Professor

Christiane ELIE

Researcher

Emmanuelle DARBON

Assistant Professor

Corinne SAULNIER

Technician

Maya LONG

Asistant Engineer

FERREIRA DOS SANTOS Luisa

PhD student

Laëtitia CARATY-PHILIPPE

Technician

Hervé LEH

Research Engineer

Rayan ZREIK

Master Intern

Latest publications

For all the publications of the Team click on the button below.

External funding

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