Strategic axes confront the future
Architecture and Dynamics of cellular structures,
and associated pathologies
Architecture and Dynamics of cellular structures, and associated pathologies
The organization and maintenance of the internal structure of cells, both eukaryotic and prokaryotic, are essential to their survival. Specialized compartments are either delimited by membranes (mitochondria, nucleus, endoplasmic reticulum, chloroplasts…), or formed by liquid phase separation phenomena (nucleolus, nuclear or cytoplasmic bodies, viral factories…). Exchanges between these compartments ensure the coordination of their activities, which involves complex and dynamic networks of macromolecules and macromolecular assemblies (cytoskeleton, motors, transporters, lipid or chromatin phases, membrane- membrane contacts…). The dysfunctions of this organization are at the origin of many pathologies.
SCIENTIFIC CHALLENGES FOR I2BC
- Role of the cytoskeleton and motors for force generation and mechanosensing in cell proliferation and migration.
- Physicochemical properties and function of non-membrane compartments (liquid organelles, self- assemblies).
- Roles of membrane remodeling and dynamic interactions between compartments.
- Changes of these organizations and cellular responses during variations in physiological conditions, cell cycle, stress.
- Origin and consequences of dysfunctions of cellular organization in pathologies.