Bioinformatics is a strong transverse axis of the department, indispensable for any functional genomics study based on high-throughput sequencing of nucleic acids or proteomics. The experimental approaches we use range from molecular genetics to genomics and rely on the increasing use of advanced cell imaging. Genome Biology teams rely on a variety of models ranging from bacteria (model and pathogenic species) to unicellular (yeasts, fungi, protists) and multi-cellular eukaryotes (plants, mice, human cells). Through the diversity of its experimental models, the department of Genome Biology addresses scientific issues ranging from the most fundamental aspects of academic research to their biomedical and environmental applications.