The I2BC core facilities are integrated into 5 National Infrastructures in Biology and Health (FRISBI, France Génomique, ProFI, France-BioImaging and Institut Français de Bioinformatique) and most of them are recognized at national level by the IBiSA label. The 500 annual users of the core facilities have access to state-of-the-art technologies and methodologies. The core facilities perform research and development, in collaboration with other national centers and with I2BC teams. Finally, the core facilities are committed to training: each year, they train ~250 users and are involved in ~10 workshops and meetings.